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Emma Guttman , MD, PhD

Dermatology, clinical focus.

• Education & Certifications

Publications

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Industry Relationships

Emma Guttman-Yassky, MD, PhD, is the Waldman Professor of Dermatology and Immunology and Health System Chair of The Department of Dermatology at the Icahn School of Medicine at Mount Sinai in New York City. She is the Director of the Occupational Dermatitis Clinic and Director of the Laboratory for Inflammatory Skin Diseases.

Dr. Guttman earned her MD degree from Sackler School of Medicine at the Tel-Aviv University, and a PhD degree from the Bar-Ilan University, Israel. After obtaining her Israeli Board certification in dermatology at Rambam Medical Center/Technion, Israel, Dr. Guttman moved to the U.S. to pursue a two-year postdoctoral fellowship at The Rockefeller University in the Laboratory for Investigative Dermatology. Upon completion of her fellowship, she became board-certified by the American Board of dermatology after a second dermatology residency training at the Weill-Cornell Medical College, in NY. Dr. Guttman’s major clinical and research focus areas are atopic dermatitis (AD)/eczema and alopecia areata. Her research made paradigm-shifting discoveries on the immunologic basis of atopic dermatitis (AD)/eczema in adults and children with atopic dermatitis, enriching the understanding of the pathophysiology of this common disorder, opening the door and accelerating testing of novel immune, pathway-specific drugs in this disease. She is now testing (both clinically and mechanistically) multiple targeted therapeutics for atopic dermatitis that target Th2, Th22, and Th17/IL-23 axis. Recently Dr. Guttman also extended her research interest to hair loss disorders such as alopecia areata and scarring hair loss disorders, chronic hand eczema, keloids, ichtyosis, and other skin diseases, in which her findings are also translated to novel therapeutic targets.

Dr. Guttman is considered one of the world’s leading experts in inflammatory skin diseases. Her achievements have been repeatedly highlighted by the media including the New York Times, ABC News, CBS News, Daily News, Reuters, Wall Street Journal, NY1, and others.

Dr. Guttman divides her time between a busy clinic, where she sees patients from all over the US and the world, that are coming to seek her advise in treating inflammatory skin diseases, and her growing laboratory that focuses on research on the mechanisms underlying inflammatory skin diseases, leading to novel treatments for these patients.

Dr. Guttman co-founded the International Eczema Council (IEC), a global organization of the key opinion leaders in eczema (>100 councilors from all continents) where she served as president from early 2018 though 2021. Dr. Guttman received many national and international awards, including the American Academy of Allergy and Clinical Immunology (AAAAI) Award for Scientific Innovation, and the American Academy of Dermatology Young Investigator award. Most recently she gave the Keynote Lecture: Atopic Dermatitis—The Road to a Personalized Medicine Approach, at the 51st ESDR Annual Meeting in the fall of 2022; and was awarded the Donald Y. M. Leung, MD, PhD, the JACI Editors’ Lectureship and Faculty Development Award, at the 2021 AAAAI Virtual Annual Meeting. Notably, Dr. Guttman and her team received the 2021 Article of the Year Award in Dermatits for “Transcriptomic Profiling of Tape-Strips from Moderate to Severe Atopic Dermatitis Patients Treated With Dupilumab”.

Dr. Guttman serves on the Board of the American Skin Association (ASA) as well as the Medical Advisory Committee of the (ASA) and was elected to the Research Advisory Council, and the National Alopecia Areata foundation (NAAF). She was also elected as a member to the American Society for Clinical Investigation (ASCI), as well as the American Dermatological Society (ADA).

Dr. Guttman is often invited as a keynote speaker to international and national meetings, and has authored ~340 peer-reviewed publications. Dr. Guttman is also the co-organizer of the Inflammatory Skin Disease Summit, that is considered one of the most successful meetings in dermatology.  

Hospital Affiliations

• Mount Sinai Morningside
• Mount Sinai Beth Israel
• Mount Sinai Brooklyn
• Mount Sinai Queens
• The Mount Sinai Hospital
• New York Eye and Ear Infirmary of Mount Sinai
• Mount Sinai West

Multi-Disciplinary Training Areas

Immunology [IMM]

• Allergy Testing
• Alopecia Areata
• Atopic Dermatitis
• Contact Dermatitis
• Fungal Infections
• Skin Allergy
• Skin Biopsy

MD, Tel-Aviv University Sackler School Of Medicine

Residency, dermatology.

Rambam Medical Center/Technion

Internship, Internal Medicine

Memorial Sloan-Kettering Cancer Center

Weill Cornell Medical College-New York Hospital

Certifications

American board of dermatology.

Paul Ehrlich Award 2024, EAACI Congress 2024

European Academy of Allergy and Clinical Immunology (EAACI) Congress

Inaugural Therapeutic Innovation Award, American Skin Association (ASA) award

American Skin Association (ASA) award

Rodan Fields Lectureship 2024, Stanford University

Stanford Medicine, Dermatology

Keynote Lecture: Atopic Dermatitis: The Road to a Personalized Medicine Approach, the 51st ESDR Annual Meeting

European Society for Dermatological Research (ESDR)

Donald Y. M. Leung, MD, PhD, the JACI Editors’ Lectureship and Faculty Development Award, the 2021 AAAAI Virtual Annual Meeting

American Academy of Allergy, Asthma & Immunology (AAAAI)

Article of the Year Award: “Transcriptomic Profiling of Tape-Strips from Moderate to Severe Atopic Dermatitis Patients Treated With Dupilumab”

American Contact Dermatitis Society (ACDS) Editorial/Publications Committee

Bettina C. Hilman, MD Lectureship and Award

American Academy of Allergy and Immunology (AAAAI)

Elected as one of 4 international organizers (two from US and two from EU) of the 2nd Keystone Symposia on Skin Health and Disease: Immune, Microbiome and Epithelia crosstalk

Keystone Symposia

Hugh A. Sampson Lectureship and Award

President, International Eczema Council

International Eczema Council

Elected to the board of the American Skin Association (ASA)

American Skin Association (ASA)

Young Investigator Award (2011)

American Academy of Dermatology

Mount Sinai Doctors East 98th Street

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Accepted insurance may vary by the doctor’s office location. Please contact the office directly to obtain the most up-to-date insurance information.

Patients with Healthfirst Medicare Advantage insurance: Effective 9/1/2024 , Mount Sinai’s primary care providers (internal medicine, family practice, and geriatrics) are not accepting new Healthfirst Medicare patients. Please contact Healthfirst for help finding a primary care provider. Healthfirst Medicare members who have a relationship with a Mount Sinai primary care provider can continue to book appointments with them.

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Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.

Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System  website .

Publications : 414

Selected Publications

• Interleukin-1α inhibitor bermekimab in patients with atopic dermatitis : randomized and nonrandomized studies. Eric L. Simpson, Emma Guttman-Yassky, Jeffrey Pawlikowski, Eric G. Ghorayeb, Takayuki Ota, Mark G. Lebwohl . Archives of Dermatological Research
• Beyond Avoidance : Advanced Therapies for Contact Dermatitis. Lu Yin, Benjamin Ungar, Emma Guttman-Yassky, David E. Cohen, Theodora K. Karagounis . Journal of Allergy and Clinical Immunology: In Practice
• Dupilumab induces hair regrowth in pediatric alopecia areata : a real-world, single-center observational study. Eden David, Neda Shokrian, Ester Del Duca, Marguerite Meariman, Jacob Glickman, Sabrina Ghalili, Seungyeon Jung, Kathryn Tan, Benjamin Ungar, Emma Guttman-Yassky . Archives of Dermatological Research

Patient Experience Rating ?

The Patient Experience Star Rating reflects our patients’ perception of how well their Mount Sinai provider communicated with them during an office visit. The Star Rating is based on patient responses to three questions on a patient experience survey, a standardized questionnaire sent to verified patients and distributed by a third party vendor, Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score.

Care Provider’s Explanation

4.7 out of 5

Care Provider’s Concern

Likelihood to recommend care provider.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Guttman  during 2023 and/or 2024 . Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

• Evommune, Inc.
• Merck Pharmaceuticals
• MCVEIH Global Meetings and Events
• Sato Pharmaceutical
• Pfizer Pharmaceuticals
• Aclaris Therapeutics
• RAPT Therapeutics, Inc.
• Merck & Co., Inc.
• Inmagene Bio
• AbbVie, Inc.
• Regeneron Pharmaceuticals, Inc.
• Artax Biopharma
• Ribon Therapeutics
• Cara Therapeutics, Inc
• HMP Education
• RBC Consultants
• Bristol-Myers Squibb
• AnaptysBio, Inc
• L & M Healthcare communication
• Sanofi Aventis
• Proteologix, Inc
• Apogee Therapeutics
• Genentech, Inc.
• Eli Lilly And Company
• Gate Bioscience
• Peerview Institute
• Sanofi US Services Inc.
• Centrexion Therapeutics Corporation
• Genzyme Corporation
• LEO Pharma A/S
• Ventyx Biosciences

Editorial Services

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our  website . Patients may wish to ask their physician about the activities they perform for companies.

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Christopher Bunick, MD/PhD

Contact info.

Associate Professor of Dermatology

Dr. Christopher Bunick is an Associate Professor of Dermatology, specializing in general medical dermatology and dermatologic surgery. He also performs unique dermatologic research studying the three-dimensional structures of skin-related proteins using x-ray crystallography and cryo-electron microscopy. He sees patients at Yale Dermatology Associates in Middlebury, CT. Dr. Bunick provides care of patients with all dermatologic conditions.

Dr. Bunick received his B.S. at Vanderbilt University (Nashville, TN), and his M.D. and Ph.D. degrees at Vanderbilt University School of Medicine. His PhD research studied the three-dimensional structures of calcium-binding proteins and proteins involved in DNA repair processes (e.g. the skin disease xeroderma pigmentosum). He completed medical internship, dermatology residency, and a dermatology research fellowship (mentored by Nobel Laureate Dr. Thomas A. Steitz) at Yale University School of Medicine (New Haven, CT). He performs laboratory research with the goal of using x-ray crystallography, cryo-electron microscopy, and biochemistry to better understand the structure-function relationship of proteins involved in normal and diseased skin and dermatologic therapeutics.

Dermatology

Other departments & organizations.

• Medical Dermatology
• Middlebury Dermatology
• Molecular Medicine, Pharmacology, and Physiology
• Orange College Affiliates
• Program in Translational Biomedicine (PTB)
• Psoriasis Treatment Program
• Yale Combined Program in the Biological and Biomedical Sciences (BBS)
• Yale Medicine

Education & Training

Principal investigator background.

Dr. Christopher Bunick, MD, PhD, is an Associate Professor of Dermatology performing dermatologic research studying the three-dimensional structures of skin-related proteins using primarily x-ray crystallography and cryo-electron microscopy. Dr. Bunick has over 25 years of experience in the field of structural biology. He leads a structural biology research program in the dermatology field, with a specific niche: “atomic resolution dermatology.” Dr. Bunick’s research focuses on determining the atomic resolution structures of proteins, protein complexes, and drug-ligand complexes that are essential to formation of a functional human skin barrier or the action of a precision medicine therapy. He uses x-ray crystallography and cryo-electron microscopy to: 1) determine the high resolution, three-dimensional structures of proteins important to both normal and diseased skin, and 2) determine the mechanism of action of how dermatology drugs bind their molecular target. Knowing the structure of various skin proteins and drugs enables a better understanding of how a protein or therapeutic functions in normal and diseased skin states. Ultimately, it may lead to the development of novel therapies or better patient care.

Areas of Active Basic Science Research

The Bunick lab applies biochemistry, structural biology (X-ray crystallography, Cryo-EM), and cell biology techniques to investigate biological processes of human skin. As a board-certified and practicing dermatologist, Dr. Bunick tackles scientific questions that can improve clinical care of patients. We have ongoing cutting edge translational research in the following areas:

1. Molecular mechanisms of intermediate filament (IF) assembly .

IFs, which include keratins, are fundamental filamentous assemblies that comprise the cellular cytoskeleton, regulate cellular signaling, and form an essential component of the human skin barrier. The Bunick lab discovered a novel assembly mechanism shared among IFs, and we continue to investigate the function of IFs.

2. Molecular mechanisms of human skin barrier integrity.

Keratin IFs regulate the human skin barrier through two key processes: i) filaggrin aggregation of keratins to form an impermeable proteinaceous barrier in the stratum corneum, and ii) keratins bind desmoplakin at desmosomes to enhance cell-cell adhesion in the epidermis. The Bunick lab has determined the only filaggrin structure and 75% of all keratin structures to date, and investigate the mechanisms of keratin assemblies in skin barrier function.

Two recent proteins studied are human profilaggrin and the keratin 1/10 complex because of their importance to skin barrier integrity and association with clinically relevant skin diseases. The NIH/NIAMS website estimates up to 90 million Americans suffer from some form of atopic dermatitis. Atopic dermatitis and other forms of severely dry skin, such as ichthyosis vulgaris, are associated with defects or mutations in profilaggrin and its processed fragment, filaggrin. Similarly, mutations mapped to keratins 1 or 10 are linked to several clinical disorders of keratinization (keratinopathies). Work on these proteins led to a 2.2 Å resolution crystal structure of the profilaggrin S100 calcium-binding domain and several 2.0 Å to 3.3 Å resolution crystal structures of complexes between the 1B and 2B helices of K1 and K10.

3. Acne vulgaris pathogenesis and mechanisms of drug therapy.

Building from our structure of the acne drug sarecycline bound to the 70S ribosome , we investigate how acne drugs function in their pathogenic target, Cutibacterium acnes , and how that impacts clinical efficacy and antibiotic resistance . We investigate how C. acnes regulates the microbiome niche of the pilosebaceous unit.

4. Molecular mechanisms of skin therapeutics in patient care. Dr. Bunick's lab works to understand the biochemical mechanisms of dermatologic drugs. Recent work on the structural mechanism of the acne vulgaris drug sarecycline was published in PNAS, and there are ongoing drug development projects in the lab in acne vulgaris, psoriasis, atopic dermatitis, cancer, and more.

Dr. Bunick currently is funded by the NIH/NIAMS (R01 Award) and a research grant from Almirall. His laboratory is open to medical students, graduate students, and post-docs motivated by and passionate for applying biochemistry and structural biology to skin disease.

Graduate & Medical Students, Post-docs, and Mentorship

Dr. Bunick's lab is committed to providing a highly intellectual and fun environment to develop the research skills necessary to succeed in life, whether in academia, industry, or elsewhere. We teach students the key processes used in our research, including protein production and purification, biochemical assays, structure determination techniques, and clinical/translational thinking. Dr. Bunick is faculty in the Yale Program in Translational Biomedicine , and participates in the BBS Track: Translational Molecular Medicine, Pharmacology, and Physiology (TMMPP).

Clinical Trials

Dr. Bunick works with the Yale Center for Clinical Investigation to lead clinical trial investigations on promising new dermatology therapeutics. Trials to date include:

- VAPAUS: A Multicenter, Phase 3 Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Safety and Efficacy of PTX-022 in the Treatment of Pachyonychia Congenita .

- TMB01-301: The ASCEND Study: A Phase III, Multicenter, Double Blinded Vehicle Controlled Study of TMB-001 - with a Parallel Optional Maximal Use Arm - in the Treatment of RXLI (X-linked) or ARCI Ichthyosis in Subjects Aged ≥ 6 Years.

Completed :

- A randomized, parallel, double-blind, vehicle-controlled study to evaluate the safety and efficacy of two different concentrations of topical TMB-001 for the treatment of congenital ichthyosis.

- A randomized, bilateral comparison, vehicle-controlled, safety and tolerability study of topical PAT-001 for the treatment of congenital ichthyosis.

Medical Subject Headings (MeSH)

Dermatology research in christopher bunick laboratory, research at a glance, yale co-authors, publications timeline, research interests, ivan lomakin, phd, leonard milstone, md, jeffrey cohen, md, kathleen cook suozzi, md, michael girardi, md, faad, intermediate filaments, crystallography, x-ray, publications, alterations in the skin microbiome in dermatologic diseases and with external exposures: cme part 2, the human skin microbiome in health: cme part 1, 683 - risk of major adverse cardiovascular events in patients with moderate-to-severe atopic dermatitis: a united states population-based study, 734 - efficacy and safety of upadacitinib vs dupliumab in adults and adolescents with moderate-to-severe atopic dermatitis: results of an open-label, efficacy assessor-blinded head-to-head phase 3b/4 study (level up), 681 - risk of malignancy excluding nonmelanoma skin cancer in patients with moderate-to-severe atopic dermatitis in the united states: a population-based study using claims data, 696 - sustained improvements over 140 weeks in signs, symptoms, and quality of life with upadacitinib in adolescents and adults with moderate-to-severe atopic dermatitis: integrated results from the phase 3 measure up 1 and measure up 2 studies, 640 - investigator- and patient-rated local tolerability in phase 3 trials of topical roflumilast in patients with psoriasis, seborrheic dermatitis, and atopic dermatitis, 697 - risk of non-melanoma skin cancer in patients with moderate-to-severe atopic dermatitis: a united states population-based study using claims data, 706 - real-world patient experience of upadacitinib-treated adults with atopic dermatitis: results from the scale-up study, 699 - prevalence and incidence of atopic dermatitis in patients with alopecia areata in the united states: a population-based study, current trials, the ascend study, academic achievements & community involvement, yale dermatology residency program application review committee, yale university school of medicine faculty advisory council, young investigator award, career development award (year 3), career development award (year 2), clinical care.

Christopher Bunick, MD, PhD, is a dermatologist who enjoys seeing how happy his patients are when their skin conditions improve. “The confidence they gain to go out into the world and not be shy about the appearance of their skin makes me feel like I am making a difference in people's lives,” says Dr. Bunick, who sees patients in Dermatology’s Middlebury location.

Dr. Bunick treats patients of all ages for all conditions that affect the skin, hair and nails. These run the gamut from pinpointing the cause of a rash to treating eczema, psoriasis, skin lupus, pigment disorders and skin infections. He regularly performs dermatologic surgery for skin cancers and other benign lesions as well.

Having an open and truthful relationship with his patients is both important and deeply rewarding to Dr. Bunick. “First and foremost, I am always honest with my patients, whether the news I am giving them is positive or not. I always reassure them that I will work very hard to help them, even if it takes time to figure out the problem,” he says. “Patients are always welcome to call if they have any questions or concerns.”

When he’s not caring for his patients, Dr. Bunick, who is an associate professor of dermatology for Yale School of Medicine, conducts research on the three-dimensional protein structures that form the skin’s barrier. “My hope is to better understand the molecular mechanisms of the skin barrier, and translate that into better topical therapies for skin issues my patients face,” Dr. Bunick says.

Clinical Specialties

Fact sheets, acne (acne vulgaris), viral warts, seborrheic keratosis, yale medicine news, 2024 ‘top doctors’ list features over 300 yale medicine physicians, itchiness, acne, and skin irritation: how to solve your facial hair problems, are you a patient.

View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

News & Links

X-ray crystal structure of sarecycline bound to bacterial ribosome, keratin 1-keratin 10 helix 2b complex, x-ray crystal structure of human profilaggrin s100 domain, cryo-em structure of cutibacterium acnes 70s ribosome.

The structure of Cutibacterium acnes 70S ribosome with the antibiotic sarecycline bound, seen with Cryo-EM microscopy at atomic resolution.

Dermatology Research Presented at Yale Life Sciences Pitchfest

Christopher g. bunick, md, phd, receives the american acne and rosacea society's 2023 research scholar award, health headlines: does the latest tiktok skin care trend really work, antibiotics for acne: groundbreaking study shows why one works best, related links.

• Dr. Bunick's Research -- FIRST Skin Foundation
• FIRST 2017 Research Grant Awarded to Dr. Christopher Bunick, Yale University
• Icky Skin Problems
• Yale Healthcast: How to prevent and treat dry skin in the winter

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Aimee S Payne, MD, PhD

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Dr. Payne is the Herbert and Florence Irving Professor and Chair of Dermatology at Columbia University Irving Medical Center. She received her BS degree in Biology from Stanford University and an MD/PhD degree in Molecular and Cellular Biology from Washington University School of Medicine, followed by dermatology residency and postdoctoral fellowship training at the University of Pennsylvania.

Dr. Payne is the 2024-2025 President of the Society for Investigative Dermatology and is a member of the American Society for Clinical Investigation, NIH/NIAMS Advisory Council, and International Pemphigus and Pemphigoid Foundation Medical Advisory Council. She also serves as co-chair of the Scientific Advisory Board at Cabaletta Bio, a company she co-founded to enable the first precision cellular immunotherapies for autoimmunity to enter human clinical trials.

Areas of Expertise / Conditions Treated

• Blistering Disorders
• Medical Dermatology

Academic Appointments

• Herbert and Florence Irving Professor of Dermatology

Administrative Titles

• Chair, Department of Dermatology
• Dermatologist-in-Chief, NewYork-Presbyterian Hospital

Hospital Affiliations

• NewYork-Presbyterian / Columbia University Irving Medical Center

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Education & Training

• BS, 1993 Biology, Stanford University
• MD, 2001 Washington University School of Medicine
• PhD, 2001 Molecular And Cellular Biology, Washington University School Of Medicine
• Internship: 2002 Pennsylvania Hospital
• Residency: 2005 Hospital of the University of Pennsylvania
• Fellowship: 2006 University of Pennsylvania

Committees, Societies, Councils

• 2023-2025: President of the Society for Investigative Dermatology
• Served as Chair of the National Institute of Arthritis and Musculoskeletal and Skin Diseases Board of Scientific Counselors
• Elected Member of the American Society for Clinical Investigation
• Elected Member of the American Dermatological Association
• Serves on the Medical Advisory Council of the International Pemphigus and Pemphigoid Foundation

Board Certifications

• Dermatology

Honors & Awards

• Co-Founder and Co-Chair of the Scientific Advisory Board of Cabaletta Bio
• Eugene J. Van Scott Award for Innovative Therapy, AAD
• Top 10 Clinical Research Forum Award
• American Society for Clinical Investigation

Researching the pathophysiology and targeted therapy of autoantibody-mediated diseases

Dr. Payne’s clinical and research expertise centers on the diagnosis and treatment of autoimmunity, with particular focus on the autoimmune blistering diseases pemphigus and pemphigoid. Her research laboratory invented a targeted immunotherapy approach for autoimmune B cell depletion known as chimeric autoantibody receptor (CAAR) T cell therapy and performed key studies leading to FDA clearance of two Investigational New Drug Applications of CAAR T cell technology for the treatment of antigen-specific subtypes of pemphigus vulgaris and myasthenia gravis.

Research Interests

• Precision cellular immunotherapies for B cell-mediated diseases
• Genetic and functional characterization of human anti-desmoglein B cell repertoires

Selected Publications

• Oh S, Mao X, Manfredo-Vieira S, Lee J, Patel D, Choi EJ, Alvarado A, Cottman-Thomas E, Maseda D, Tsao PY, Ellebrecht CT, Khella SL, Richman DP, O’Connor KC, Herzberg U, Binder GK, Milone MC, Basu S, Payne AS : Precision targeting of autoantigen-specific B-cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T-cells. Nature Biotechnol in press, 2023.
• Tovanabutra N, Bax CE, Feng R, Kushner CJ, Payne AS : Temporal outcomes after rituximab therapy for pemphigus. J. Invest. Dermatol. 142(4): 1058-1064, 2022 Notes: doi:10.1016/j.jid.2021.09.013.
• Lee J, Lundgren DK, Mao X, Manfredo-Vieira S, Nunez-Cruz S, Williams EF, Assenmacher CA, Radaelli E, Oh S, Wang B, Ellebrecht CT, Fraietta JA, Milone MC, Payne AS : Antigen specific B-cell depletion for precision therapy of mucosal pemphigus vulgaris. J Clin Invest 130(12): 6317-6324, 2020 Notes: doi:10.1172/JCI13841.
• Maehara T, Kaneko N, Perugino CA, Mattoo H, Kers J, Allard-Chamard H, Mahajan VS, Liu H, Murphy SJ, Ghebremichael M, Fox DA, Payne AS , Lafyatis R, Stone JH, Khanna D, Pillai S: Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis. J Clin Invest 130(5): 2451-2464, Jan 2020 Notes: https://doi.org/10.1172/JCI131700 .
• Kushner CJ, Wang S, Tovanabutra N, Tsai DE, Werth VP, Payne AS : Factors associated with complete remission after rituximab therapy for pemphigus. JAMA Dermatol 155(12): 1404-09, 2019 Notes: doi:10.1001/jamadermatol.2019.3236.
• Cho A, Caldara AL, Ran NA, Menne Z, Kauffman RC, Affer M, Llovet A, Norwood C, Scanlan A, Mantus G, Bradley B, Zimmer S, Schmidt T, Hertl M, Payne AS , Feldman R, Kowalczyk AP, Wrammert J : Single-cell analysis suggests that ongoing affinity maturation drives the emergence of pemphigus vulgaris autoimmune disease. Cell Rep 28(4): 909-922, Jul 23 2019.
• Ellebrecht CT, Mukherjee EM, Zheng Q, Choi EJ, Reddy SG, Mao X, Payne AS : Autoreactive IgG and IgA B cells evolve through distinct subclass switch pathways in the autoimmune disease pemphigus vulgaris. Cell Rep 24(9): 2370-2380, Aug 28 2018.
• Mao X, Cho MJ, Ellebrecht CT, Mukherjee EM, Payne AS : Stat3 regulates desmoglein 3 transcription in epithelial keratinocytes. JCI Insight 2(9): e92253, May 4 2017.
• Ellebrecht CT, Bhoj VG, Nace A, Choi EJ, Mao X, Cho MJ, Di Zenzo G, Lanzavecchia A, Seykora JT, Cotsarelis G, Milone MC, Payne AS : Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science 353(6295): 179-184, Jul 8 2016.
• Cho MJ, Lo ASY, Mao X, Nagler AR, Ellebrecht CT, Mukherjee EM, Hammers CM, Choi EJ, Sharma PM, Uduman M, Li H, Rux AH, Farber SA, Rubin CB, Kleinstein SH, Sachais BS, Posner MR, Cavacini LA, Payne AS : Shared VH1-46 gene usage by pemphigus vulgaris autoantibodies indicates common humoral immune responses among patients. Nature Commun 5: 4167, Jun 19 2014.

Luis Garza , MD , PhD

Dermatology.

• Johns Hopkins School of Medicine Faculty

4.9 of 5 stars

14 insurances accepted, primary academic title.

Professor of Dermatology

Dr. Luis Andres Garza is a professor of dermatology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include hidradenitis suppurativa, alopecia areata, and general dermatology.

Dr. Garza received his undergraduate degree in neurobiology from Cornell University. He earned his M.D. and Ph.D. together from the medical scientist training program at the University of Pennsylvania School of Medicine. Dr. Garza completed his residency in dermatology at the University of Michigan and performed his fellowship in dermatology at the University of Pennsylvania. He joined the Johns Hopkins faculty in 2009.

In addition to treating patients, Dr. Garza runs a molecular biology laboratory that studies skin stem cells and wound healing with an emphasis on identifying the next generation of wound therapeutics and diagnostics.

http://www.hopkinsmedicine.org/dermatology/our_experts/CV/garza_l_cv_%20aug_2016.pdf

Clinical Trials Summary

"Effects of Antibiotics and Acne on the Skin Microbiome"

"Feasibility Study for Fibroblast Autologous Skin Grafts"

"Timolol for the Treatment of Acne and Rosacea"

Recent News Articles and Media Coverage

#TomorrowsDiscoveries: Healing by Regeneration , Johns Hopkins Medicine (May 20, 2016)

Scientists Grow New Hair In A Lab, But Don't Rush To Buy A Comb , NPR, October 21, 2013

What to Do If You're Going Bald , Men’s Health, May 15, 2013

A War on Baldness, Fought in the Follicle , The New York Times, July 28, 2012

Additional Academic Titles

Professor of Oncology, Professor of Cell Biology

Contact for Research Inquiries

1550 Orleans Street Suite 204 Koch CRBII Baltimore, MD 21231

Phone: (410) 955-8662 Fax: (410) 614-0635

Research Interests

and Wound Healing, Skin Regeneration, Skin Stem Cells

Lab Website

Our group is interested in investigating hypotheses on basic skin questions that are directly relevant to skin disease in humans. We hope that through rigorous hypothesis-driven research into skin biology, we will gain important insights that will directly improve patient care.

Our model system is the skin. To answer basic questions regarding stem cell biology and regeneration, we choose the skin because of its accessibility, the depth of current knowledge, and the complexity of epithelial/mesenchymal interactions in the context of relevant vasculature, nerves and hematopoietic cells.

The current focus of the lab is what controls and maintains skin identity. Regions of our skin are remarkably diverse in function and features. Despite constant cellular turnover, each area’s features are remarkably maintained. We study how, under normal conditions, identity is actively maintained and how it might be manipulated. We also study how, during wounding, skin identity is typically lost (i.e., scar), but in rare situations complete regeneration occurs.

Understanding these questions will have broad significance to regeneration and stem cell biology in multiple organs. Understanding wound healing programs that re-initiate embryonic developmental patterns might eventually lead to insights on how to trigger the re-growth of a severed human limb, for example.

Research Summary

Dr. Garza runs a molecular biology laboratory that studies skin stem cells and wound healing with an emphasis on identifying the next generation of wound therapeutics and diagnostics. 

Please visit his lab at: Garza Lab Web Page – Learn about us and our work! (lgarzalab.com)

Selected Publications

Kim D, Chen R, Sheu M, Kim N, Kim S, Islam N, Wier EM, Wang G, Li A, Park A, Son W, Evans B, Yu V, Prizmic VP, Oh E, Wang Z, Yu J, Huang W, Archer NK, Hu Z, Clemetson N, Nelson AM, Chien A, Okoye GA, Miller LS, Ghiaur G, Kang S, Jones JW, Kane MA, Garza LA. Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3. Nature communications . 2019;10(1):2811. Epub 2019/06/28. doi: 10.1038/s41467-019-10811-y. PubMed PMID: 31243280; PubMed Central PMCID: PMCPMC6594970.

Nelson AM, Reddy SK, Ratliff TS, Hossain MZ, Katseff AS, Zhu AS, Chang E, Resnik SR, Page C, Kim D, Whittam AJ, Miller LS, Garza LA. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration. Cell Stem Cell . 2015;17(2):139-51. Epub 2015/08/09. doi: 10.1016/j.stem.2015.07.008. PubMed PMID: 26253200; PubMed Central PMCID: PMCPMC4529957.

Wang G, Sweren E, Andrews W, Li Y, Chen J, Xue Y, Wier E, Alphonse MP, Luo L, Miao Y, Chen R, Zeng D, Lee S, Li A, Dare E, Kim D, Archer NK, Reddy SK, Resar L, Hu Z, Grice EA, Kane MA, Garza LA. Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism. Science advances . 2023;9(1):eabo7555. Epub 20230104. doi: 10.1126/sciadv.abo7555. PubMed PMID: 36598999.

Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, Islam N, Li A, Xue Y, Chen J, Chen Y, Lee S, Wang Y, Wang S, Archer NK, Andrews W, Kane MA, Dare E, Reddy SK, Hu Z, Grice EA, Miller LS, Garza LA. Bacteria induce skin regeneration via IL-1β signaling. Cell Host & Microbe . 2021. Epub 2021/04/03. doi: 10.1016/j.chom.2021.03.003. PubMed PMID: 33798492.

• Use of Itaconate and its Derivatives/Analogues to Induce Hair Growth, 20230025922
• Prodrugs of Itaconate and Methyl Itaconate, 20230028516
• Methods for Using Autologous Fibroblasts to Alter Skin Identity, 20150110750
• Compositions and Methods for Promoting Skin Regeneration and Hair Growth, 20170056310
• Elected to American Society for Clinical Investigation (ASCI), 1/1/23
• Daniel Nathans Scholar at Johns Hopkins University School of Medicine, 1/1/22
• American Skin Association Research Achievement Award in Translational Research, 1/1/22
• Interurban Clinical Club Baltimore Counselor, 1/1/22

Memberships

• American Academy of Dermatology
• Society for Investigative Dermatology
• 601 North Caroline Street, Floor 8 , Baltimore , MD 21287
• phone: 410-955-5933
• fax: 410-502-2309

University of Michigan Health

University of pennsylvania school of medicine, board certifications.

• First Health
• Geisinger Health Plan
• HealthSmart/Accel
• Johns Hopkins Health Plans
• Pennsylvania's Preferred Health Networks (PPHN)
• Point Comfort Underwriters
• Private Healthcare Systems (PHCS)
• UnitedHealthcare
• Veteran Affairs Community Care Network (Optum-VACCN)

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

Highly knowledgeable about my condition he is treating

Dr. Luis Garza was super informative and easy to understand. A really nice doctor that seems to actually like and care for his patients well being.

Both the resident (i forget his name) and Dr. Garza are amazing. They heard my concerns, they explained the disease process in a way I could understand, developed a plan of care for me that included ME. Answered all the questions that my wife and I had and I left at ease.

He made me feel confortable.

Him and his colleague were both awesome

Excellent communication, treatment, and care

Dr. Garza began with a friendly hello and good eye contact. He asked questions, listened, provided explanations and options. He was engaged with me, not the computer screen. I felt completely confident in his understanding my concerns and was happy with his suggestions.

Dr. Garza is my preferred dermatologist!

Was very attentive to my concerns about my medical issue, gave me treatment options and understood why I made the decision I did. Very thoughtful explanations of my situation and options.

Been seeing Dr Garza for 6 years or more. Very professional in dermatology care for my Alopecia

He is a top-notch expert in his specialty and I feel grateful to be seen by him. He is always patient and supportive to me and it gives me faith that there will be a cure.

Doctor Gaza was courteous, professional, listened carefully, answered all my questions, took his time explaining my condition and enlightened me about medications prescribed.

I had a follow up appointment with the dermatologist in ref., to my hair that is growing back fine.

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• Richard Gallo

Richard Gallo, MD, PhD

Professor and Chair, Department of Dermatology

• [email protected]
• Personal Website

Education & Training

Publications.

Dr. Richard Gallo is a leading physician scientist in the fields of dermatology, immunology, epithelial biology and microbiology. He received his post-graduate training at Harvard and is now a Distinguished Professor and the Founding Chair of the Department of Dermatology at the University of California, San Diego.  His groundbreaking research discovered the existence of antimicrobial peptides in mammalian skin, a field that has now grown to be seen as a major part of clinical medicine. Gallo's work has also revolutionized our knowledge of the function of the skin microbiome, with many research breakthroughs that have greatly advanced understanding of several human skin diseases including atopic dermatitis, rosacea and acne.  He has received major awards from the Society of Investigative Dermatology, the Japanese Society of Investigative Dermatology, the European Societies of Investigative Dermatology as well as several other scientific organizations both within and outside of the field of Dermatology. He has been elected as a fellow of multiple prestigious societies including the National Academy of Medicine (2023), American Association for the Advancement of Science (2017), the American Association of Microbiology (2014), and the American Society of Clinical Investigation (2003).  Dr. Gallo is one of the highest cited active investigators (h-index 143), with over 75,000 citations from more than 450 publications in prestigious journals including: Nature, Science, New England J. of Medicine, Immunity, Cell and others.

Harvard Medical School Dermatology Residency Program  1997-1999

University of Rochester School of Medicine & Dentistry MD, PhD, Medicine, Toxicology, Biophysics 1980-1986

University of Chicago AB, Biology 1976-1980

Profiles.ucsd.edu

Vladimir Botchkarev, MD, PhD

Adjunct Professor of Dermatology

Boston university school of medicine, administrative office, boston university school of medicine, dept of dermatology.

609 Albany Street, Boston, MA 02118 Tel: 617-358-9700 Fax: 617-358-9709

Vladimir Botchkarev, MD, PhD is Research Associate Professor in the Department of Dermatology. He received his medical training at Chuvash State University in Cheboksary, Russian and his doctoral training at People’s Friendship University in Moscow, Russia. He was a recipient of the Research Career Development Award from the Dermatology Foundation and Independent Scientist Award from the National Institutes of Health. He is also a recipient of the research grants from the NIAMS and NCI. His name was included in the books 2000 Outstanding Scientists of the 21st Century, Great Minds of the 21st Century and Who is Who in Medicine. His primary research interests are the molecular mechanisms of hair growth and pathobiology of different forms of hair loss.

Anna Kersh, MD, PhD

Sees patients age 18 and up

• Assistant Professor of Dermatology at the Hospital of the University of Pennsylvania
• Dr. Kersh is a Penn Medicine physician.

Please click here if the scheduling module does not load.

• Acanthosis Nigricans
• Acne Surgery
• Actinic Cheilitis
• Actinic Keratosis
• Acute Generalized Exanthematous Pustulosis
• Allergic Contact Dermatitis
• Alopecia Areata
• Anal Condyloma
• Angular Cheilitis
• Anogenital Warts (Condyloma Acuminata)
• Aphthous Ulcers
• Athlete's Foot
• Atypical Mole
• Basal Cell Carcinoma
• Benign Neoplasm of Skin
• Benign Neoplasm of the Lip
• Biologic Therapy for Skin Diseases
• Blistering Disease
• Bullous Disease
• Bullous Pemphigoid
• Cafe Au Lait Spots
• Calcinosis Cutis
• Cherry Angioma
• Chronic Wounds
• Cicatricial Pemphigoid
• Condyloma Lata
• Congenital Nevi
• Contact and Allergic Dermatitis of the Eyelid
• Contact Dermatitis
• Cosmetic Dermatology
• Cracked and Dry Skin
• Cryosurgery of Skin Lesions
• Cutaneous Amyloidosis
• Cutaneous B Cell Lymphoma
• Cutaneous Candidiasis
• Cutaneous Horn
• Cutaneous Larva Migrans
• Cutaneous Vasculitis
• Dermatitis Herpetiformis
• Dermatofibrosarcoma Protuberans
• Dermatographism
• Dermatologic Surgery
• Dermatophytosis
• Destruction of Benign Skin Lesions
• Destruction of Premalignant Skin Lesion
• Diaper Rash
• Drug Reaction
• Dyshidrosis
• Dysplastic Nevus
• Electrosurgery for Skin Lesions
• Epidermoid Cyst
• Epidermolysis Bullosa
• Erythema Ab Igne
• Erythema Migrans
• Erythema Multiforme
• Erythema Nodosum
• Erythroderma
• Excision of Benign Lesions
• Excision of Malignant Lesions
• Facial Aging
• Folliculitis
• Fungal Skin Infections (Dermatomycosis)
• Genital Herpes
• Genital Herpes, Female
• Genital Herpes, Male
• Genital Warts (Condyloma Acuminatum)
• Granuloma Annulare
• Hair Diseases
• Herpes Simplex Dermatitis of the Eyelid
• Herpes Simplex Virus (HSV)
• Herpetic Whitlow
• Hidradenitis Suppurativa (Acne Inversa)
• Hives (Urticaria)
• Hyperhidrosis (Excessive Sweating)
• Hyperkeratosis
• Hyperpigmentation
• Hyperpigmentation of Eyelids
• Hypertrichosis
• Impetigo Herpetiformis
• Inclusion Cyst
• Keloid Scar
• Keloid Scar Removal
• Keratin Cyst
• Keratoacanthoma
• Keratosis Pilaris
• Lichen Nitidus
• Lichen Planus
• Lichen Sclerosus
• Lichen Simplex
• Linear IgA Bullous Disease
• Livedo Reticularis
• Livedoid Vasculopathy
• Localized Scleroderma
• Lupus Panniculitis
• Merkel Cell Carcinoma
• Mole Examination
• Mole Mapping
• Molluscum Contagiosum
• Nail Disorders
• Nail Fungus
• Necrobiosis Lipoidica
• Non-Melanoma Skin Cancer
• Panniculitis
• Parapsoriasis
• Pemphigus Vulgaris
• Photosensitivity Reactions
• Pigmented Lesions
• Plantar Wart
• Polymorphous Light Eruption
• Prurigo Nodularis
• Pruritic Urticarial Papules and Plaques of Pregnancy (PUPP)
• Pseudofolliculitis Barbae
• Pyoderma Gangrenosum
• Pyogenic Granuloma
• Scalp Disorders
• Scalp Psoriasis
• Scleroderma
• Sebaceous Cyst Removal
• Sebaceous Hyperplasia
• Seborrheic Dermatitis
• Seborrheic Eczema
• Seborrheic Keratosis
• Sensitive Skin
• Shingles (Herpes Zoster)
• Skin Abnormalities
• Skin Biopsy
• Skin Bullae
• Skin Cancer
• Skin Cancer Screening
• Skin Cancer Surgery
• Skin Changes
• Skin Disease
• Skin Examination
• Skin Patch Tests
• Skin Pigmentation Disorders
• Skin Tag Removal
• Solar Dermatitis
• Squamous Cell Carcinoma of the Skin
• Staph Infection
• Stasis Dermatitis
• Stevens-Johnson Syndrome
• Striae Gravidarum
• Subacute Cutaneous Lupus
• Sun Damaged Skin
• Sweet's Syndrome
• Telangiectasia
• Tinea Corporis
• Tinea Cruris
• Tinea Manus
• Tinea Nigra
• Tinea Versicolor
• Toxic Epidermal Necrolysis
• Viral Exanthem
• Wart Removal

Programs and Centers

• Penn Acne and Rosacea Services
• Penn Aging Skin Services
• Penn Allergic Contact Dermatitis Services
• Penn Atopic Dermatitis Services
• Penn Autoimmune Disease Services
• Penn General Dermatology Services
• Penn Infectious Disease-Related Dermatology Services
• Penn Psoriasis Services

Board Certification

• Dermatology, 2021

Education and Training

Penn Dermatology Perelman

Perelman Center for Advanced Medicine South Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104

A facility of the Hospital of the University of Pennsylvania

View details

Penn Medicine Hospital Privileges

• Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
• Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
• Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Overall Ratings

The Patient Satisfaction Rating is an average of all responses to the care provider related question shown above from our internal platform, PMX Feedback. Responses are measured on a scale of 1 to 5 with 5 being the best score. Scores reflect either the most recent 12 months of surveys or the most recent 30 surveys overall. Data is updated monthly and comments remain on the profile for 12 months.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Patients that are treated in outpatient or hospital environments may receive different surveys.

• Aetna US Healthcare
• Amerihealth Caritas
• Amerihealth Caritas Medicare
• Centivo Health Plan
• Cigna HealthSpring
• Clover Health Plan
• Devon Health Services (Americare)
• Gateway Health Plan
• Geisinger Health Plan
• Geisinger Medicaid
• Global Medical Management
• HealthAmerica / HealthAssurance, a Coventry Plan
• HealthPartners
• HealthPartners Medicare
• HealthSmart
• Highmark Blue Shield
• Homestead Smart Health Plans/Claim Watcher
• Horizon Blue Cross Blue Shield of New Jersey
• Humana / Choicecare
• Humana / Medicare
• Imagine Health 360
• Independence Blue Cross (Keystone East)
• Keystone First
• Keystone First Medicare
• NJ Medicaid
• NJ Qualcare
• Oscar Health Plan of PA
• Oxford Health Plan
• PA Health and Wellness (Centene) Medicare
• PA Medicaid
• PA Medicare
• Provider Partners Health Plan
• Rail Road Medicare / Palmetto GBA
• United Healthcare
• UnitedHealthcare Community Plan
• US Family Health Plan
• Veterans Choice Program

Selected Publications

Abbott JJ, Jiang AJ, Rauck C, Frank DM, Fortuna D, Kersh A, Rubin AI.: Cutaneous metastatic gastric carcinoma with plasmacytoid features: A novel histopathologic pitfall in the diagnosis of primary cutaneous plasmacytoma J Cutan Pathol 50 (1): 8-11,2023.

Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH.: Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome J Clin Invest 133 : e162137,2023.

Bhattarcharya, S., Sheng, E., Murphy, C., Wei, J., Kersh, A.E., Nelson, C.A., Aschanyan, H.A., Steele, K., Forrestel, A., Seykora, J.T., Micheletti, R.G., James, W.D., Rosenbach, M., Leung, T.H.: Targeted therapy guided by molecular identification of PIK3R1 mutation in acute febrile neutrophilic dermatosis J Clin Invest 133 (1): e162137,2023.

Torre EA, Kersh AE, Fischer AS, Xu X, Rosenbach M, Shields BE.: Angiokeratoma-like purpuric palmar nodules following chemotherapy Dermatol Online J 27 (8): 2021.

Kersh AE, Johansen M, Ojeaga A, de la Feld S.: Hand Dermatitis in the Time of COVID-19: A Review of Occupational Irritant Contact Dermatitis Dermatitis 32 (2): 86-93,2021.

Kersh AE, Schuchter LM, Elenitsas R, Chu EY.: Hypohidrosis as an immune-related adverse event of checkpoint inhibitor therapy Immunotherapy 12 (13): 951-956,2020.

Bhattarcharya, S., Sheng, E., Murphy, C., Wei, J., Kersh, A.E., Nelson, C.A., Aschanyan, H.A., Steele, K., Forrestel, A., Seykora, J.T., Micheletti, R.G., James, W.D., Rosenbach, M., Leung, T.H.: Targeted therapy guided by molecular identification of PIK3R1 mutation in acute febrile neutrophilic dermatosis J Clin Invest 133 (1): 202.

Kersh AE, Feldman RJ.: Autoimmune Sequelae Following Rituximab Therapy: A Review of the Literature and Potential Immunologic Mechanisms J Clin Rheumatol 24 (8): 427-435,2018.

Kersh AE, Helms S, de la Feld S.: Glove-Related Allergic Contact Dermatitis Dermatitis 29 (1): 13-21,2018.

Kersh AE, Ng S, Chang YM, Sasaki M, Thomas SN, Kissick HT, Lesinski GB, Kudchadkar RR, Waller EK, Pollack BP.: Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer J Clin Pharmacol 58 (1): 7-24,2018.

Academic Contact Information

421 Curie Boulevard Biomedical Research Building II/III, #1040 Philadelphia, PA 19104 Patient appointments: 800-789-7366

• American Academy of Dermatology, National
• American Contact Dermatitis Society, National
• Society for Investigative Dermatology, National
• Women’s Dermatologic Society, National

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WELCOME BACK

Howard Y. Chang, MD, PhD

Dermatologist , general dermatologist, cutaneous oncology specialist, medical oncologist.

Virginia and D. K. Ludwig Professor of Cancer Research, Professor of Genetics and, by courtesy, of Pathology

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Professional summary, education & certifications.

• Fellowship: Stanford University Dept of Dermatology (2004) CA
• Residency: Stanford University Dermatology Residency (2003) CA
• Internship: Santa Clara Valley Medical Center Dept of Medicine (2001) CA
• Board Certification: American Board of Dermatology, Dermatology (2004)
• Medical Education: Harvard Medical School (2000) MA
• Ph.D., MIT, Biology (1998)
• A.B., Harvard, Biochemistry (1994)

Honors & Awards

• Alfred Marchionini Research Prize, Alfred Marchionini Foundation (2011)
• CE.R.I.E.S. Award, Chanel Research and Technology (2010)
• Clinical Scientist Career Development Award (K08), NIH (2004-2009)
• Early Career Scientist, Howard Hughes Medical Institute (2009-2015)
• Elected Member, American Society for Clinical Investigation (2009)
• Investigator, Howard Hughes Medical Institute (2018)
• Jonathan Kraft Prize for Excellence in Cancer Research, Massachusetts General Hospital (2024)
• Judson Daland Prize, American Philosophical Society (2014)
• King Faisal Prize in Science, King Faisal Foundation (2024)
• Lurie Prize in Biomedical Sciences, Foundation for NIH (2024)
• Member, American Academy of Arts and Sciences (2020)
• Member, National Academy of Medicine (2017)
• Member, National Academy of Sciences (2020)
• Montagna Lecture, Society for Investigative Dermatology (2012)
• NAS Award in Molecular Biology, National Academy of Science (2018)
• New Faculty Award, California Institute for Regenerative Medicine (2008-2013)
• Outstanding Investigator Award, National Cancer Institute (2016)
• Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Institute (2015)
• Physician-Scientist Career Development Award, Dermatology Foundation (2004)
• Research Scholar Award, American Cancer Society (2007-2010)
• Salvador E. Luria Lecture, Massachusetts Institute of Technology (2012)
• Scholar Award, Damon Runyon Cancer Research Foundation (2006-2008)
• Senior Scholar Award in Aging, Ellison Medical Foundation (2009)
• Stanley J. Korsmeyer Award, American Society for Clinical Investigation (2024)
• Vilcek Prize for Creative Promise, Vilcek Foundation (2009)
• Young Investigator Award, American Academy of Dermatology (2003)

Memberships

• Editorial Board, Molecular Cell (2014 - Present)

Administrative Appointments

• Director, NIH Center of Excellence in Genomic Science: Center for Personal Dynamic Regulome (2014 - 2024)
• Director, RNA Medicine Program (2022 - Present)

Publications

• Proteases for cell suicide: Functions and regulation of caspases Chang, H. Y., & Yang, X. L. (2000). Proteases for cell suicide: Functions and regulation of caspases. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS , 64 (4), 821-?
• Diversity, topographic differentiation, and positional memory in human fibroblasts Chang, H. Y., Chi, J. T., Dudoit, S., Bondre, C., van de Rijn, M., Botstein, D., & Brown, P. O. (2002). Diversity, topographic differentiation, and positional memory in human fibroblasts. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 99 (20), 12877–82.
• Genomewide view of gene silencing by small interfering RNAs Chi, J. T., Chang, H. Y., Wang, N. N., Chang, D. S., Dunphy, N., & Brown, P. O. (2003). Genomewide view of gene silencing by small interfering RNAs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 100 (11), 6343–46.
• Myelogenous leukemia cutis resembling stasis dermatitis Chang, H. Y., Wong, K. M., Bosenberg, M., McKee, P. H., & Haynes, H. A. (2003). Myelogenous leukemia cutis resembling stasis dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY , 49 (1), 128–129.
• Eruptive xanthomas associated with olanzapine use Chang, H. Y., Ridky, T. W., Kimball, A. B., Hughes, E., & Oro, A. E. (2003). Eruptive xanthomas associated with olanzapine use. ARCHIVES OF DERMATOLOGY , 139 (8), 1045–48.
• Endothelial cell diversity revealed by global expression profiling Chi, J. T., Chang, H. Y., Haraldsen, G., Jahnsen, F. L., Troyanskaya, O. G., Chang, D. S., … Brown, P. O. (2003). Endothelial cell diversity revealed by global expression profiling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 100 (19), 10623–28.
• CYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B SWANSON, S. K. H., Born, T., ZYDOWSKY, L. D., Cho, H. J., Chang, H. Y., Walsh, C. T., & Rusnak, F. (1992). CYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 89 (9), 3741–3745.
• ACTIVE-SITE MUTANTS OF HUMAN CYCLOPHILIN-A SEPARATE PEPTIDYL-PROLYL ISOMERASE ACTIVITY FROM CYCLOSPORINE-A BINDING AND CALCINEURIN INHIBITION ZYDOWSKY, L. D., Etzkorn, F. A., Chang, H. Y., Ferguson, S. B., STOLZ, L. A., Ho, S. I., & Walsh, C. T. (1992). ACTIVE-SITE MUTANTS OF HUMAN CYCLOPHILIN-A SEPARATE PEPTIDYL-PROLYL ISOMERASE ACTIVITY FROM CYCLOSPORINE-A BINDING AND CALCINEURIN INHIBITION. PROTEIN SCIENCE , 1 (9), 1092–1099.
• Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. Chang, H. Y., Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., Montgomery, K., … Brown, P. O. (2004). Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biology , 2 (2), E7-?
• Kinetics and specificity of Fas ligand induction in toxic epidermal necrolysis Chang, H. Y., Cooper, Z. A., Swetter, S. A., & Marinkovich, M. P. (2004). Kinetics and specificity of Fas ligand induction in toxic epidermal necrolysis. ARCHIVES OF DERMATOLOGY , 140 (2), 242–44.
• Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival Chang, H. Y., Nuyten, D. S. A., Sneddon, J. B., Hastie, T., Tibshirani, R., Sorlie, T., … van de Vijver, M. J. (2005). Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 102 (10), 3738–43.
• Learning more from microarrays: Insights from modules and networks Wong, D. J., & Chang, H. Y. (2005). Learning more from microarrays: Insights from modules and networks. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 125 (2), 175–82.
• Genetic regulators of large-scale transcriptional signatures in cancer Adler, A. S., Lin, M. H., Horlings, H., Nuyten, D. S. A., Van de Vijver, M. J., & Chang, H. Y. (2006). Genetic regulators of large-scale transcriptional signatures in cancer. NATURE GENETICS , 38 (4), 421–30.
• From description to causality - Mechanisms of gene expression signatures in cancer Adler, A. S., & Chang, H. Y. (2006). From description to causality - Mechanisms of gene expression signatures in cancer. CELL CYCLE , 5 (11), 1148–51.
• MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species Ray, S., Atkuri, K. R., Deb-Basu, D., Adler, A. S., Chang, H. Y., Herzenberg, L. A., & Felsher, D. W. (2006). MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species. CANCER RESEARCH , 66 (13), 6598–6605.
• Anatomic demarcation by positional variation in fibroblast gene expression programs Rinn, J. L., Bondre, C., Gladstone, H. B., Brown, P. O., & Chang, H. Y. (2006). Anatomic demarcation by positional variation in fibroblast gene expression programs. PLOS GENETICS , 2 (7), 1084–96.
• Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation Sneddon, J. B., Zhen, H. H., Montgomery, K., van de Rijn, M., Tward, A. D., West, R., … Brown, P. O. (2006). Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 103 (40), 14842–47.
• GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN Huang, W., Chang, H. Y., Fei, T., Wu, H., & Chen, Y.-G. (2007). GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. ONCOGENE , 26 (17), 2471–82.
• Predicting a local recurrence after breast-conserving therapy by gene expression profiling Nuyten, D. S. A., Kreike, B., Hart, A. A. M., Chi, J.-T. A., Sneddon, J. B., Wessels, L. F. A., … van de Vijver, M. J. (2006). Predicting a local recurrence after breast-conserving therapy by gene expression profiling. BREAST CANCER RESEARCH , 8 (5).
• Spontaneous autoimmunity prevented by thymic expression of a single self-antigen DeVoss, J., Hou, Y., Johannes, K., Lu, W., Liou, G. I., Rinn, J., … Anderson, M. S. (2006). Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. JOURNAL OF EXPERIMENTAL MEDICINE , 203 (12), 2727–35.
• Microarray analysis of stem cells and differentiation Chang, H. Y., Thomson, J. A., & Chen, X. (2006). Microarray analysis of stem cells and differentiation. STEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLS , 420 , 225–54.
• Patterning skin pigmentation via dickkopf Chang, H. Y. (2007). Patterning skin pigmentation via dickkopf. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 127 (5), 994–95.
• Decoding global gene expression programs in liver cancer by noninvasive imaging Segal, E., Sirlin, C. B., Ooi, C., Adler, A. S., Gollub, J., Chen, X., … Kuo, M. D. (2007). Decoding global gene expression programs in liver cancer by noninvasive imaging. NATURE BIOTECHNOLOGY , 25 (6), 675–80.
• Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs O'Geen, H., Squazzo, S. L., Iyengar, S., Blahnik, K., Rinn, J. L., Chang, H. Y., … Farnham, P. J. (2007). Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs. PLOS GENETICS , 3 (6), 916–26.
• A transcriptional program mediating entry into cellular quiescence Liu, H., Adler, A. S., Segal, E., & Chang, H. Y. (2007). A transcriptional program mediating entry into cellular quiescence. PLOS GENETICS , 3 (6), 996–1008.
• Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X., Brugmann, S. A., … Chang, H. Y. (2007). Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs. CELL , 129 (7), 1311–23.
• Turning skin into embryonic stem cells Chang, H. Y., & Cotsarelis, G. (2007). Turning skin into embryonic stem cells. NATURE MEDICINE , 13 (7), 783–84.
• A histone H3 lysine 27 demethylase regulates animal posterior development Lan, F., Bayliss, P. E., Rinn, J. L., Whetstine, J. R., Wang, J. K., Chen, S., … Shi, Y. (2007). A histone H3 lysine 27 demethylase regulates animal posterior development. NATURE , 449 (7163), 689–U3.
• Motif module map reveals enforcement of aging by continual NF-kappa B activity Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007). Motif module map reveals enforcement of aging by continual NF-kappa B activity. GENES & DEVELOPMENT , 21 (24), 3244–57.
• Revealing targeted therapy for human cancer by gene module maps Wong, D. J., Nuyten, D. S. A., Regev, A., Lin, M., Adler, A. S., Segal, E., … Chang, H. Y. (2008). Revealing targeted therapy for human cancer by gene module maps. CANCER RESEARCH , 68 (2), 369–78.
• CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression Adler, A. S., Littlepage, L. E., Lin, M., Kawahara, T. L. A., Wong, D. J., Werb, Z., & Chang, H. Y. (2008). CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. CANCER RESEARCH , 68 (2), 506–15.
• A dermal HOX transcriptional program regulates site-specific epidermal fate Rinn, J. L., Wang, J. K., Allen, N., Brugmann, S. A., Mikels, A. J., Liu, H., … Chang, H. Y. (2008). A dermal HOX transcriptional program regulates site-specific epidermal fate. GENES & DEVELOPMENT , 22 (3), 303–7.
• Systematic functional characterization of cis-regulatory motifs in human core promoters Sinha, S., Adler, A. S., Field, Y., Chang, H. Y., & Segal, E. (2008). Systematic functional characterization of cis-regulatory motifs in human core promoters. GENOME RESEARCH , 18 (3), 477–88.
• Reversal of aging by NF kappa B blockade Adler, A. S., Kawahara, T. L. A., Segal, E., & Chang, H. Y. (2008). Reversal of aging by NF kappa B blockade. CELL CYCLE , 7 (5), 556–59.
• A systems biology approach to anatomic diversity of skin Rinn, J. L., Wang, J. K., Liu, H., Montgomery, K., van de Rijn, M., & Chang, H. Y. (2008). A systems biology approach to anatomic diversity of skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 128 (4), 776–82.
• SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., … Chua, K. F. (2008). SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. NATURE , 452 (7186), 492–U16.
• Module map of stem cell genes guides creation of epithelial cancer stem cells Wong, D. J., Liu, H., Ridky, T. W., Cassarino, D., Segal, E., & Chang, H. Y. (2008). Module map of stem cell genes guides creation of epithelial cancer stem cells. CELL STEM CELL , 2 (4), 333–44.
• Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire Su, M. A., Giang, K., Zumer, K., Jiang, H., Oven, I., Rinn, J. L., … Anderson, M. S. (2008). Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. JOURNAL OF CLINICAL INVESTIGATION , 118 (5), 1712–26.
• Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3 Sen, G. L., Webster, D. E., Barragan, D. I., Chang, H. Y., & Khavari, P. A. (2008). Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. GENES & DEVELOPMENT , 22 (14), 1865–70.
• Deletional tolerance mediated by extrathymic Aire-expressing cells Gardner, J. M., DeVoss, J. J., Friedman, R. S., Wong, D. J., Tan, Y. X., Zhou, X., … Anderson, M. S. (2008). Deletional tolerance mediated by extrathymic Aire-expressing cells. SCIENCE , 321 (5890), 843–47.
• Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification Nuyten, D. S. A., Hastie, T., Chi, J.-T. A., Chang, H. Y., & van de Vijver, M. J. (2008). Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification. EUROPEAN JOURNAL OF CANCER , 44 (15), 2319–29.
• Stemness, cancer and cancer stem cells Wong, D. J., Segal, E., & Chang, H. Y. (2008). Stemness, cancer and cancer stem cells. CELL CYCLE , 7 (23), 3622–24.
• Global Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory and Lipid Genes Saaf, A. M., Tengvall-Linder, M., Chang, H. Y., Adler, A. S., Wahlgren, C.-F., Scheynius, A., … Bradley, M. (2008). Global Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory and Lipid Genes. PLOS ONE , 3 (12).
• SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-kappa B-Dependent Gene Expression and Organismal Life Span Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., … Chua, K. F. (2009). SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-kappa B-Dependent Gene Expression and Organismal Life Span. CELL , 136 (1), 62–74.
• Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis Chung, L., Fiorentino, D. F., Benbarak, M. J., Adler, A. S., Mariano, M. M., Paniagua, R. T., … Robinson, W. H. (2009). Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis. ARTHRITIS AND RHEUMATISM , 60 (2), 584–91.
• ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation Hung, T., Binda, O., Champagne, K. S., Kuo, A. J., Johnson, K., Chang, H. Y., … Gozani, O. (2009). ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation. MOLECULAR CELL , 33 (2), 248–56.
• Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells Somervaille, T. C. P., Matheny, C. J., Spencer, G. J., Iwasaki, M., Rinn, J. L., Witten, D. M., … Cleary, M. L. (2009). Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells. CELL STEM CELL , 4 (2), 129–40.
• Genome-Wide Views of Chromatin Structure Rando, O. J., & Chang, H. Y. (2009). Genome-Wide Views of Chromatin Structure. ANNUAL REVIEW OF BIOCHEMISTRY , 78 , 245–71.
• Regeneration, repair and remembering identity: the three Rs of Hox gene expression Wang, K. C., Helms, J. A., & Chang, H. Y. (2009). Regeneration, repair and remembering identity: the three Rs of Hox gene expression. TRENDS IN CELL BIOLOGY , 19 (6), 268–75.
• Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression Reuter, J. A., Ortiz-Urda, S., Kretz, M., Garcia, J., Scholl, F. A., Pasmooij, A. M. G., … Khavari, P. A. (2009). Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression. CANCER CELL , 15 (6), 477–88.
• Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment Chan, D. A., Kawahara, T. L. A., Sutphin, P. D., Chang, H. Y., Chi, J.-T., & Giaccia, A. J. (2009). Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment. CANCER CELL , 15 (6), 527–38.
• Gene dates, parties and galas Symposium on Chromatin Dynamics and Higher Order Organization Chang, H. Y., Cuvier, O., & Dekker, J. (2009). Gene dates, parties and galas Symposium on Chromatin Dynamics and Higher Order Organization. EMBO REPORTS , 10 (7), 689–93.
• Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells Chan, K. S., Espinosa, I., Chao, M., Wong, D., Ailles, L., Diehn, M., … Weissman, I. L. (2009). Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 106 (33), 14016–21.
• Anatomic Demarcation of Cells: Genes to Patterns Chang, H. Y. (2009). Anatomic Demarcation of Cells: Genes to Patterns. SCIENCE , 326 (5957), 1206–7.
• The histone demethylase UTX enables RB-dependent cell fate control Wang, J. K., Tsai, M.-C., Poulin, G., Adler, A. S., Chen, S., Liu, H., … Chang, H. Y. (2010). The histone demethylase UTX enables RB-dependent cell fate control. GENES & DEVELOPMENT , 24 (4), 327–32.
• Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis Gupta, R. A., Shah, N., Wang, K. C., Kim, J., Horlings, H. M., Wong, D. J., … Chang, H. Y. (2010). Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. NATURE , 464 (7291), 1071–U148.
• Tumor suppression by the histone demethylase UTX Tsai, M.-C., Wang, J. K., & Chang, H. Y. (2010). Tumor suppression by the histone demethylase UTX. CELL CYCLE , 9 (11), 2043–44.
• Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., … Chang, H. Y. (2010). Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes. SCIENCE , 329 (5992), 689–93.
• Genome-wide measurement of RNA secondary structure in yeast Kertesz, M., Wan, Y., Mazor, E., Rinn, J. L., Nutter, R. C., Chang, H. Y., & Segal, E. (2010). Genome-wide measurement of RNA secondary structure in yeast. NATURE , 467 (7311), 103–7.
• HOTAIR Flight of noncoding RNAs in cancer metastasis Wan, Y., & Chang, H. Y. (2010). HOTAIR Flight of noncoding RNAs in cancer metastasis. CELL CYCLE , 9 (17), 3391–92.
• Long noncoding RNA in genome regulation Prospects and mechanisms Hung, T., & Chang, H. Y. (2010). Long noncoding RNA in genome regulation Prospects and mechanisms. RNA BIOLOGY , 7 (5), 582–85.
• G1 arrest and differentiation can occur independently of Rb family function Wirt, S. E., Adler, A. S., Gebala, V., Weimann, J. M., Schaffer, B. E., Saddic, L. A., … Sage, J. (2010). G1 arrest and differentiation can occur independently of Rb family function. JOURNAL OF CELL BIOLOGY , 191 (4), 809–25.
• Noncoding RNA Landmarks of Pluripotency and Reprogramming Ouyang, Z., Zheng, G. X. Y., & Chang, H. Y. (2010). Noncoding RNA Landmarks of Pluripotency and Reprogramming. CELL STEM CELL , 7 (6), 649–50.
• Long Intergenic Noncoding RNAs: New Links in Cancer Progression Tsai, M.-C., Spitale, R. C., & Chang, H. Y. (2011). Long Intergenic Noncoding RNAs: New Links in Cancer Progression. CANCER RESEARCH , 71 (1), 3–7.
• RNA templating the epigenome Long noncoding RNAs as molecular scaffolds Spitale, R. C., Tsai, M.-C., & Chang, H. Y. (2011). RNA templating the epigenome Long noncoding RNAs as molecular scaffolds. EPIGENETICS , 6 (5), 539–43.
• A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression Wang, K. C., Yang, Y. W., Liu, B., Sanyal, A., Corces-Zimmerman, R., Chen, Y., … Chang, H. Y. (2011). A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. NATURE , 472 (7341), 120–U158.
• Long noncoding RNAs and human disease Wapinski, O., & Chang, H. Y. (2011). Long noncoding RNAs and human disease. TRENDS IN CELL BIOLOGY , 21 (6), 354–61.
• Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters Hung, T., Wang, Y., Lin, M. F., Koegel, A. K., Kotake, Y., Grant, G. D., … Chang, H. Y. (2011). Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. NATURE GENETICS , 43 (7), 621–U196.
• Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks Kawahara, T. L. A., Rapicavoli, N. A., Wu, A. R., Qu, K., Quake, S. R., & Chang, H. Y. (2011). Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks. PLOS GENETICS , 7 (6).
• Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival Alastalo, T.-P., Li, M., Perez, V. D. J., Pham, D., Sawada, H., Wang, J. K., … Rabinovitch, M. (2011). Disruption of PPAR gamma/beta-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. JOURNAL OF CLINICAL INVESTIGATION , 121 (9), 3735–46.
• Understanding the transcriptome through RNA structure Wan, Y., Kertesz, M., Spitale, R. C., Segal, E., & Chang, H. Y. (2011). Understanding the transcriptome through RNA structure. NATURE REVIEWS GENETICS , 12 (9), 641–55.
• Molecular Mechanisms of Long Noncoding RNAs Wang, K. C., & Chang, H. Y. (2011). Molecular Mechanisms of Long Noncoding RNAs. MOLECULAR CELL , 43 (6), 904–14.
• Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons Marro, S., Pang, Z. P., Yang, N., Tsai, M.-C., Qu, K., Chang, H. Y., … Wernig, M. (2011). Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons. CELL STEM CELL , 9 (4), 374–82.
• Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions Chu, C., Qu, K., Zhong, F. L., Artandi, S. E., & Chang, H. Y. (2011). Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions. MOLECULAR CELL , 44 (4), 667–78.
• Active chromatin and noncoding RNAs: an intimate relationship Flynn, R. A., & Chang, H. Y. (2012). Active chromatin and noncoding RNAs: an intimate relationship. CURRENT OPINION IN GENETICS & DEVELOPMENT , 22 (2), 172–78.
• A Molecular Signature for Purified Definitive Endoderm Guides Differentiation and Isolation of Endoderm from Mouse and Human Embryonic Stem Cells Wang, P., McKnight, K. D., Wong, D. J., Rodriguez, R. T., Sugiyama, T., Gu, X., … Kim, S. K. (2012). A Molecular Signature for Purified Definitive Endoderm Guides Differentiation and Isolation of Endoderm from Mouse and Human Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT , 21 (12), 2273–87.
• Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock Rando, T. A., & Chang, H. Y. (2012). Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock. CELL , 148 (1-2), 46–57.
• Suppression of progenitor differentiation requires the long noncoding RNA ANCR Kretz, M., Webster, D. E., Flockhart, R. J., Lee, C. S., Zehnder, A., Lopez-Pajares, V., … Khavari, P. A. (2012). Suppression of progenitor differentiation requires the long noncoding RNA ANCR. GENES & DEVELOPMENT , 26 (4), 338–43.
• Chromatin isolation by RNA purification (ChIRP). Chu, C., Quinn, J., & Chang, H. Y. (2012). Chromatin isolation by RNA purification (ChIRP). Journal of Visualized Experiments : JoVE , (61).
• High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation Wu, A. R., Kawahara, T. L. A., Rapicavoli, N. A., van Riggelen, J., Shroff, E. H., Xu, L., … Quake, S. R. (2012). High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation. LAB ON A CHIP , 12 (12), 2190–98.
• The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression Littlepage, L. E., Adler, A. S., Kouros-Mehr, H., Huang, G., Chou, J., Krig, S. R., … Werb, Z. (2012). The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression. CANCER DISCOVERY , 2 (7), 638–51.
• Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment: A Pilot Study Chang, A. L. S., Bitter, P. H., Qu, K., Lin, M., Rapicavoli, N. A., & Chang, H. Y. (2013). Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment: A Pilot Study. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 133 (2), 394–402.
• Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts Lee, C. S., Ungewickell, A., Bhaduri, A., Qu, K., Webster, D. E., Armstrong, R., … Khavari, P. A. (2012). Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts. BLOOD , 120 (16), 3288–97.
• Genome-wide Measurement of RNA Folding Energies Wan, Y., Qu, K., Ouyang, Z., Kertesz, M., Li, J., Tibshirani, R., … Chang, H. Y. (2012). Genome-wide Measurement of RNA Folding Energies. MOLECULAR CELL , 48 (2), 169–81.
• SeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data Ouyang, Z., Snyder, M. P., & Chang, H. Y. (2013). SeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data. GENOME RESEARCH , 23 (2), 377–87.
• Detection of Long Non-Coding RNA in Archival Tissue: Correlation with Polycomb Protein Expression in Primary and Metastatic Breast Carcinoma Chisholm, K. M., Wan, Y., Li, R., Montgomery, K. D., Chang, H. Y., & West, R. B. (2012). Detection of Long Non-Coding RNA in Archival Tissue: Correlation with Polycomb Protein Expression in Primary and Metastatic Breast Carcinoma. PLOS ONE , 7 (10).
• Systematic reconstruction of RNA functional motifs with high-throughput microfluidics Martin, L., Meier, M., Lyons, S. M., Sit, R. V., Marzluff, W. F., Quake, S. R., & Chang, H. Y. (2012). Systematic reconstruction of RNA functional motifs with high-throughput microfluidics. NATURE METHODS , 9 (12), 1192–U85.
• Identification of proteins binding coding and non-coding human RNAs using protein microarrays Siprashvili, Z., Webster, D. E., Kretz, M., Johnston, D., Rinn, J. L., Chang, H. Y., & Khavari, P. A. (2012). Identification of proteins binding coding and non-coding human RNAs using protein microarrays. BMC GENOMICS , 13 .
• RNA SHAPE analysis in living cells. Spitale, R. C., Crisalli, P., Flynn, R. A., Torre, E. A., Kool, E. T., & Chang, H. Y. (2013). RNA SHAPE analysis in living cells. Nature Chemical Biology , 9 (1), 18–20.
• Control of somatic tissue differentiation by the long non-coding RNA TINCR. Kretz, M., Siprashvili, Z., Chu, C., Webster, D. E., Zehnder, A., Qu, K., … Khavari, P. A. (2013). Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature , 493 (7431), 231–35.
• Cytotopic localization by long noncoding RNAs Batista, P. J., & Chang, H. Y. (2013). Cytotopic localization by long noncoding RNAs. CURRENT OPINION IN CELL BIOLOGY , 25 (2), 195–99.
• The NeST Long ncRNA Controls Microbial Susceptibility and Epigenetic Activation of the Interferon-gamma Locus Gomez, J. A., Wapinski, O. L., Yang, Y. W., Bureau, J.-F., Gopinath, S., Monack, D. M., … Kirkegaard, K. (2013). The NeST Long ncRNA Controls Microbial Susceptibility and Epigenetic Activation of the Interferon-gamma Locus. CELL , 152 (4), 743–54.
• Long Noncoding RNAs: Cellular Address Codes in Development and Disease Batista, P. J., & Chang, H. Y. (2013). Long Noncoding RNAs: Cellular Address Codes in Development and Disease. CELL , 152 (6), 1298–1307.
• Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing. Wan, Y., Qu, K., Ouyang, Z., & Chang, H. Y. (2013). Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing. Nature Protocols , 8 (5), 849–69.
• ASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN Chang, H. Y., Takei, K., SYDOR, A. M., Born, T., Rusnak, F., & Jay, D. G. (1995). ASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN. NATURE , 376 (6542), 686–690.
• ACTIVATION OF CLN1 AND CLN2 G(1) CYCLIN GENE-EXPRESSION BY BCK2 DICOMO, C. J., Chang, H., & Arndt, K. T. (1995). ACTIVATION OF CLN1 AND CLN2 G(1) CYCLIN GENE-EXPRESSION BY BCK2. MOLECULAR AND CELLULAR BIOLOGY , 15 (4), 1835–1846.
• Daxx, a novel Fas-binding protein that activates JNK and apoptosis Yang, X. L., KHOSRAVIFAR, R., Chang, H. Y., & Baltimore, D. (1997). Daxx, a novel Fas-binding protein that activates JNK and apoptosis. CELL , 89 (7), 1067–1076.
• Autoproteolytic activation of pro-caspases by oligomerization Yang, X. L., Chang, H. Y., & Baltimore, D. (1998). Autoproteolytic activation of pro-caspases by oligomerization. MOLECULAR CELL , 1 (2), 319–325.
• Essential role of CED-4 oligomerization in CED-3 activation and apoptosis Yang, X. L., Chang, H. Y., & Baltimore, D. (1998). Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. SCIENCE , 281 (5381), 1355–1357.
• Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx Chang, H. Y., Nishitoh, H., Yang, X. L., ICHIJO, H., & Baltimore, D. (1998). Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx. SCIENCE , 281 (5384), 1860–1863.
• Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation Chang, H. Y., Yang, X. L., & Baltimore, D. (1999). Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 96 (4), 1252–1256.
• High throughput RNA sequencing of Sezary syndrome and cutaneous squamous cell carcinoma Lee, C., Qu, K., Webster, D., Kretz, M., MAH, A., Ungewickell, A., … Khavari, P. (2011). High throughput RNA sequencing of Sezary syndrome and cutaneous squamous cell carcinoma. Presented at the 71st Annual Meeting of the Society-for-Investigative-Dermatology, PHOENIX,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ: NATURE PUBLISHING GROUP.
• Maintenance of the epidermal progenitor state requires the long non-coding RNA Linc8D Lee, C., Kretz, M., Webster, D., Flockhart, R., Qu, K., MAH, A., … Khavari, P. (2011). Maintenance of the epidermal progenitor state requires the long non-coding RNA Linc8D. Presented at the 71st Annual Meeting of the Society-for-Investigative-Dermatology, PHOENIX,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ: NATURE PUBLISHING GROUP.
• Role of CSN5 in epidermal homeostasis Wong, D. J., Adler, A. S., Lin, M., Liu, H., & Chang, H. Y. (2006). Role of CSN5 in epidermal homeostasis. Presented at the 67th Annual Meeting of the Society-for-Investigative-Dermatology, PHILADELPHIA,PA,PA,PA,PA,PA,PA: NATURE PUBLISHING GROUP.
• CSN5 overexpression inhibits UVB-induced epidermal apoptosis in vivo WONG, D. I., Liu, H., Lin, M., Tran, M., Liu, D., & Chang, H. Y. (2008). CSN5 overexpression inhibits UVB-induced epidermal apoptosis in vivo. Presented at the International Investigative Dermatology Meeting, KYOTO,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN: NATURE PUBLISHING GROUP.
• Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers Brunner, A. L., Beck, A. H., Edris, B., Sweeney, R. T., Zhu, S. X., Li, R., … West, R. B. (2012). Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers. GENOME BIOLOGY , 13 (8).
• Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds Chang, H. Y., Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., Montgomery, K., … Brown, P. O. (2004). Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds. PLOS BIOLOGY , 2 (2), 206–14.
• Identification of genes promoting exceptional skin youthfulness Chang, A. S., Atzmon, G., Bergman, A., Chang, H. Y., & Barzilai, N. (2012). Identification of genes promoting exceptional skin youthfulness. Presented at the 75th Annual Meeting of the Society-for-Investigative-Dermatology, RALEIGH,NC,NC,NC,NC,NC,NC,NC: NATURE PUBLISHING GROUP.
• Molecular framework for response to imatinib mesylate in systemic sclerosis Chung, L., Fiorentino, D. F., Benbarak, M. J., Adler, A. S., Mariano, M. M., Paniagua, R. T., … Robinson, W. H. (2008). Molecular framework for response to imatinib mesylate in systemic sclerosis. ARTHRITIS AND RHEUMATISM . SAN FRANCISCO,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA,CA: WILEY-BLACKWELL.
• Long noncoding RNAs and human disease (vol 21, pg 354, 2011) Wapinski, O., & Chang, H. Y. (2011). Long noncoding RNAs and human disease (vol 21, pg 354, 2011). TRENDS IN CELL BIOLOGY , 21 (10), 561–61.
• Evaluation of an imatinib response gene signature in patients with systemic sclerosis Chung, L., Ruiz, P., Wood, T., Shoor, S., Robinson, W., Whitfield, M., … Fiorentino, D. (2010). Evaluation of an imatinib response gene signature in patients with systemic sclerosis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . CLINICAL & EXPER RHEUMATOLOGY.
• Toward creating epidermal cancer stem cells by reactivation of an embryonic stem cell transcriptional program Wong, D. J., Liu, H., Ridky, T. W., Cassarino, D., Segal, E., & Chang, H. Y. (2007). Toward creating epidermal cancer stem cells by reactivation of an embryonic stem cell transcriptional program. Presented at the 68th Annual Meeting of the Society-for-Investigative-Dermatology, LOS ANGELES,CA,CA,CA,CA,CA,CA: NATURE PUBLISHING GROUP.
• Stem cell gene module map guides creation of epidermal cancer stem cells Wong, D. J., Liu, H., Ridky, T. W., Cassarino, D., Segal, E., & Chang, H. Y. (2009). Stem cell gene module map guides creation of epidermal cancer stem cells. Presented at the 69th Annual Meeting of the Society-of-Investigative-Dermatology, MONTREAL,CANADA,CANADA,CANADA,CANADA,CANADA,CANADA: NATURE PUBLISHING GROUP.
• Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding Chen, Y., Wan, B., Wang, K. C., Cao, F., Yang, Y., Protacio, A., … Lei, M. (2011). Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO REPORTS , 12 (8), 797–803.
• The role of CSN5 in UV-mediated DNA damage Liu, H., Wong, D. J., & Chang, H. Y. (2007). The role of CSN5 in UV-mediated DNA damage. Presented at the 68th Annual Meeting of the Society-for-Investigative-Dermatology, LOS ANGELES,CA,CA,CA,CA,CA,CA: NATURE PUBLISHING GROUP.
• Long noncoding RNA programs active chromatin domain to coordinate homeotic gene expression Wang, K. C., Yang, Y. W., Liu, B., Sanyal, A., Corces-Zimmerman, R., Chen, Y., … Chang, H. Y. (2011). Long noncoding RNA programs active chromatin domain to coordinate homeotic gene expression. Presented at the 71st Annual Meeting of the Society-for-Investigative-Dermatology, PHOENIX,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ,AZ: NATURE PUBLISHING GROUP.
• Site-specific regulatory function of HOX noncoding RNAs in skin fibroblasts Gupta, R. A., Rinn, J., & Chang, H. Y. (2008). Site-specific regulatory function of HOX noncoding RNAs in skin fibroblasts. Presented at the International Investigative Dermatology Meeting, KYOTO,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN,JAPAN: NATURE PUBLISHING GROUP.
• A TGF beta-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity Sargent, J. L., Milano, A., Bhattacharyya, S., Varga, J., Connolly, M. K., Chang, H. Y., & Whitfield, M. L. (2010). A TGF beta-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 130 (3), 694–705.
• Genome Regulation by Long Noncoding RNAs Rinn, J. L., & Chang, H. Y. (2012). Genome Regulation by Long Noncoding RNAs. ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 , 81 , 145–66.
• Tandem Stem-Loops in roX RNAs Act Together to Mediate X Chromosome Dosage Compensation in Drosophila Ilik, I. A., Quinn, J. J., Georgiev, P., Tavares-Cadete, F., Maticzka, D., Toscano, S., … Akhtar, A. (2013). Tandem Stem-Loops in roX RNAs Act Together to Mediate X Chromosome Dosage Compensation in Drosophila. MOLECULAR CELL , 51 (2), 156–73.
• Uncovering the role of genomic "dark matter" in human disease Martin, L., & Chang, H. Y. (2012). Uncovering the role of genomic "dark matter" in human disease. JOURNAL OF CLINICAL INVESTIGATION , 122 (5), 1589–95.
• HOXB13 Mediates Tamoxifen Resistance and Invasiveness in Human Breast Cancer by Suppressing ERa and Inducing IL-6 Expression. Shah, N., Jin, K., Cruz, L.-A., Park, S., Sadik, H., Cho, S., … Sukumar, S. (2013). HOXB13 Mediates Tamoxifen Resistance and Invasiveness in Human Breast Cancer by Suppressing ERa and Inducing IL-6 Expression. Cancer Research , 73 (17), 5449–58.
• A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. Rapicavoli, N. A., Qu, K., Zhang, J., Mikhail, M., Laberge, R.-M., & Chang, H. Y. (2013). A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. ELife , 2 .
• Targeted disruption of hotair leads to homeotic transformation and gene derepression. Li, L., Liu, B., Wapinski, O. L., Tsai, M.-C., Qu, K., Zhang, J., … Chang, H. Y. (2013). Targeted disruption of hotair leads to homeotic transformation and gene derepression. Cell Reports , 5 (1), 3–12.
• Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons Wapinski, O. L., Vierbuchen, T., Qu, K., Lee, Q. Y., Chanda, S., Fuentes, D. R., … Wernig, M. (2013). Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons. CELL , 155 (3), 621–35.
• Augmenting endogenous Wnt signaling improves skin wound healing. Whyte, J. L., Smith, A. A., Liu, B., Manzano, W. R., Evans, N. D., Dhamdhere, G. R., … Helms, J. A. (2013). Augmenting endogenous Wnt signaling improves skin wound healing. PloS One , 8 (10).
• Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing Whyte, J. L., Smith, A. A., Liu, B., Manzano, W. R., Evans, N. D., Dhamdhere, G. R., … Helms, J. A. (2013). Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing. PLOS ONE , 8 (10).
• Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013). Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nature Methods , 10 (12), 1213–18.
• Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Yang, Y. W., Flynn, R. A., Chen, Y., Qu, K., Wan, B., Wang, K. C., … Chang, H. Y. (2014). Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. ELife , 3 .
• Landscape and variation of RNA secondary structure across the human transcriptome. Wan, Y., Qu, K., Zhang, Q. C., Flynn, R. A., Manor, O., Ouyang, Z., … Chang, H. Y. (2014). Landscape and variation of RNA secondary structure across the human transcriptome. Nature , 505 (7485), 706–9.
• Identification of genes promoting skin youthfulness by genome-wide association study. Chang, A. L. S., Atzmon, G., Bergman, A., Brugmann, S., Atwood, S. X., Chang, H. Y., & Barzilai, N. (2014). Identification of genes promoting skin youthfulness by genome-wide association study. Journal of Investigative Dermatology , 134 (3), 651–57.
• Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes. Buenrostro, J. D., Araya, C. L., Chircus, L. M., Layton, C. J., Chang, H. Y., Snyder, M. P., & Greenleaf, W. J. (2014). Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes. Nature Biotechnology , 32 (6), 562–68.
• Identification of a Selective Polymerase Enables Detection of N-6-Methyladenosine in RNA Harcourt, E. M., Ehrenschwender, T., Batista, P. J., Chang, H. Y., & Kool, E. T. (2013). Identification of a Selective Polymerase Enables Detection of N-6-Methyladenosine in RNA. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 135 (51), 19079–82.
• Long noncoding RNAs in cell-fate programming and reprogramming. Flynn, R. A., & Chang, H. Y. (2014). Long noncoding RNAs in cell-fate programming and reprogramming. Cell Stem Cell , 14 (6), 752–61.
• Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs Zheng, G. X. Y., Do, B. T., Webster, D. E., Khavari, P. A., & Chang, H. Y. (2014). Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs. NATURE STRUCTURAL & MOLECULAR BIOLOGY , 21 (7), 585–90.
• Control of somatic tissue differentiation by the long non-coding RNA TINCR Kretz, M., Siprashvili, Z., Chu, C., Webster, D. E., Zehnder, A., Qu, K., … Khavari, P. A. (2013). Control of somatic tissue differentiation by the long non-coding RNA TINCR. NATURE , 493 (7431), 231–U245.
• Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs. Zheng, G. X. Y., Do, B. T., Webster, D. E., Khavari, P. A., & Chang, H. Y. (2014). Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs. Nature Structural & Molecular Biology , 21 (7), 585–90.
• Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. Quinn, J. J., Ilik, I. A., Qu, K., Georgiev, P., Chu, C., Akhtar, A., & Chang, H. Y. (2014). Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. Nature Biotechnology , 32 (9), 933–40.
• RNA switch at enhancers. Quinn, J. J., & Chang, H. Y. (2014). RNA switch at enhancers. Nature Genetics , 46 (9), 929–31.
• An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development. Benitez, C. M., Qu, K., Sugiyama, T., Pauerstein, P. T., Liu, Y., Tsai, J., … Kim, S. K. (2014). An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development. PLoS Genetics , 10 (10).
• Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification Quinn, J. J., Ilik, I. A., Qu, K., Georgiev, P., Chu, C., Alchtar, A., & Chang, H. Y. (2014). Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. NATURE BIOTECHNOLOGY , 32 (9), 933–40.
• Physiological roles of long noncoding RNAs: insight from knockout mice Li, L., & Chang, H. Y. (2014). Physiological roles of long noncoding RNAs: insight from knockout mice. TRENDS IN CELL BIOLOGY , 24 (10), 594–602.
• RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Calo, E., Flynn, R. A., Martin, L., Spitale, R. C., Chang, H. Y., & Wysocka, J. (2015). RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Nature , 518 (7538), 249–53.
• m(6)A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells. Batista, P. J., Molinie, B., Wang, J., Qu, K., Zhang, J., Li, L., … Chang, H. Y. (2014). m(6)A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells. Cell Stem Cell , 15 (6), 707–19.
• An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development Benitez, C. M., Qu, K., Sugiyama, T., Pauerstein, P. T., Liu, Y., Tsai, J., … Kim, S. K. (2014). An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development. PLOS GENETICS , 10 (10).
• RNA structural analysis by evolving SHAPE chemistry Spitale, R. C., Flynn, R. A., Torre, E. A., Kool, E. T., & Chang, H. Y. (2014). RNA structural analysis by evolving SHAPE chemistry. WILEY INTERDISCIPLINARY REVIEWS-RNA , 5 (6), 867–81.
• Dissecting noncoding and pathogen RNA-protein interactomes Flynn, R. A., Martin, L., Spitale, R. C., Do, B. T., Sagan, S. M., Zarnegar, B., … Chang, H. Y. (2015). Dissecting noncoding and pathogen RNA-protein interactomes. RNA-A PUBLICATION OF THE RNA SOCIETY , 21 (1), 135–43.
• In Situ Dissection of RNA Functional Subunits by Domain-Specific Chromatin Isolation by RNA Purification (dChIRP). Quinn, J. J., & Chang, H. Y. (2015). In Situ Dissection of RNA Functional Subunits by Domain-Specific Chromatin Isolation by RNA Purification (dChIRP). Methods in Molecular Biology (Clifton, N.J.) , 1262 , 199–213.
• ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. Buenrostro, J. D., Wu, B., Chang, H. Y., & Greenleaf, W. J. (2015). ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.] , 109 , 21 29 1–9.
• Genomics: CRISPR engineering turns on genes. Cho, S. W., & Chang, H. Y. (2015). Genomics: CRISPR engineering turns on genes. Nature , 517 (7536), 560–62.
• Systematic Discovery of Xist RNA Binding Proteins Chu, C., Zhang, Q. C., da Rocha, S. T., Flynn, R. A., Bharadwaj, M., Calabrese, J. M., … Chang, H. Y. (2015). Systematic Discovery of Xist RNA Binding Proteins. CELL , 161 (2), 404–16.
• Structural imprints in vivo decode RNA regulatory mechanisms. Spitale, R. C., Flynn, R. A., Zhang, Q. C., Crisalli, P., Lee, B., Jung, J.-W., … Chang, H. Y. (2015). Structural imprints in vivo decode RNA regulatory mechanisms. Nature , 519 (7544), 486–90.
• Chromatin Isolation by RNA Purification (ChIRP) Chu, C., Quinn, J., & Chang, H. Y. (2012). Chromatin Isolation by RNA Purification (ChIRP). JOVE-JOURNAL OF VISUALIZED EXPERIMENTS , (61).
• Chromophore assisted laser inactivation of cellular proteins Jay, D. G., Wang, F. S., Chang, H. Y., SYDOR, A. M., & Liao, J. C. (1997). Chromophore assisted laser inactivation of cellular proteins. Presented at the Conference on Functional Imaging and Optical Manipulation of Living Cells, SAN JOSE,CA,CA: SPIE - INT SOC OPTICAL ENGINEERING.
• Structure and Thermodynamics of N-6-Methyladenosine in RNA: A Spring-Loaded Base Modification Roost, C., Lynch, S. R., Batista, P. J., Qu, K., Chang, H. Y., & Kool, E. T. (2015). Structure and Thermodynamics of N-6-Methyladenosine in RNA: A Spring-Loaded Base Modification. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 137 (5), 2107–15.
• HOXA3 Modulates Injury-Induced Mobilization and Recruitment of Bone Marrow-Derived Cells Mace, K. A., Restivo, T. E., Rinn, J. L., Paquet, A. C., Chang, H. Y., Young, D. M., & Boudreau, N. J. (2009). HOXA3 Modulates Injury-Induced Mobilization and Recruitment of Bone Marrow-Derived Cells. STEM CELLS , 27 (7), 1654–65.
• Technologies to probe functions and mechanisms of long noncoding RNAs Chu, C., Spitale, R. C., & Chang, H. Y. (2015). Technologies to probe functions and mechanisms of long noncoding RNAs. NATURE STRUCTURAL & MOLECULAR BIOLOGY , 22 (1), 29–35.
• Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark Corley, M., Solem, A., Qu, K., Chang, H. Y., & Laederach, A. (2015). Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark. NUCLEIC ACIDS RESEARCH , 43 (3), 1859–68.
• Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. Grow, E. J., Flynn, R. A., Chavez, S. L., Bayless, N. L., Wossidlo, M., Wesche, D. J., … Wysocka, J. (2015). Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. Nature , 522 (7555), 221–25.
• Abstract 158: Identification of BMP-Responsive Long Noncoding RNAs in Pluripotent Cells. Paik, K. J., Qu, K., Hsueh, B., Torre, E. A., Flynn, R. A., Chung, M. T., … Wan, D. C. (2014). Abstract 158: Identification of BMP-Responsive Long Noncoding RNAs in Pluripotent Cells. Plastic and Reconstructive Surgery , 133 (3), 174-?
• Long Noncoding RNA in Hematopoiesis and Immunity Satpathy, A. T., & Chang, H. Y. (2015). Long Noncoding RNA in Hematopoiesis and Immunity. IMMUNITY , 42 (5), 792–804.
• Single-cell chromatin accessibility reveals principles of regulatory variation. Buenrostro, J. D., Wu, B., Litzenburger, U. M., Ruff, D., Gonzales, M. L., Snyder, M. P., … Greenleaf, W. J. (2015). Single-cell chromatin accessibility reveals principles of regulatory variation. Nature , 523 (7561), 486–90.
• Single-cell chromatin accessibility reveals principles of regulatory variation Buenostro, J. D., Wu, B., Litzenburger, U. M., Ruff, D., Gonzales, M. L., Snyder, M. P., … Greenleaf, W. J. (2015). Single-cell chromatin accessibility reveals principles of regulatory variation. NATURE , 523 (7561), 486–U264.
• Physiological roles of long noncoding RNAs: insight from knockout mice. Li, L., & Chang, H. Y. (2014). Physiological roles of long noncoding RNAs: insight from knockout mice. Trends in Cell Biology , 24 (10), 594–602.
• Structural imprints in vivo decode RNA regulatory mechanisms Spitale, R. C., Flynn, R. A., Zhang, Q. C., Crisalli, P., Lee, B., Jung, J.-W., … Chang, H. Y. (2015). Structural imprints in vivo decode RNA regulatory mechanisms. NATURE , 519 (7544), 486-?
• Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells Grow, E. J., Flynn, R. A., Chavez, S. L., Bayless, N. L., Wossidlo, M., Wesche, D. J., … Wysocka, J. (2015). Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. NATURE , 522 (7555), 221-?
• RNA structural analysis by evolving SHAPE chemistry. Spitale, R. C., Flynn, R. A., Torre, E. A., Kool, E. T., & Chang, H. Y. (2014). RNA structural analysis by evolving SHAPE chemistry. Wiley Interdisciplinary Reviews. RNA , 5 (6), 867–81.
• Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation Mazumdar, C., Shen, Y., Xavy, S., Zhao, F., Reinisch, A., Li, R., … Majeti, R. (2015). Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation. CELL STEM CELL , 17 (6), 1–14.
• Unique features of long non-coding RNA biogenesis and function Quinn, J. J., & Chang, H. Y. (2016). Unique features of long non-coding RNA biogenesis and function. NATURE REVIEWS GENETICS , 17 (1), 47–62.
• Systematic Characterization of Long Noncoding RNAs Reveals the Contrasting Coordination of Cis- and Trans-Molecular Regulation in Human Fetal and Adult Hearts He, C., Hu, H., Wilson, K. D., Wu, H., Feng, J., Xia, S., … Wu, J. C. (2016). Systematic Characterization of Long Noncoding RNAs Reveals the Contrasting Coordination of Cis- and Trans-Molecular Regulation in Human Fetal and Adult Hearts. CIRCULATION-CARDIOVASCULAR GENETICS , 9 (2), 110–18.
• The histone chaperone CAF-1 safeguards somatic cell identity Cheloufi, S., Elling, U., Hopfgartner, B., Jung, Y. L., Murn, J., Ninova, M., … Hochedlinger, K. (2015). The histone chaperone CAF-1 safeguards somatic cell identity. NATURE , 528 (7581), 218-?
• CD44+ Cells in Head and Neck Squamous Cell Carcinoma Suppress T-Cell-Mediated Immunity by Selective Constitutive and Inducible Expression of PD-L1. Lee, Y., Shin, J. H., Longmire, M., Wang, H., Kohrt, H. E., Chang, H. Y., & Sunwoo, J. B. (2016). CD44+ Cells in Head and Neck Squamous Cell Carcinoma Suppress T-Cell-Mediated Immunity by Selective Constitutive and Inducible Expression of PD-L1. Clinical Cancer Research , 22 (14), 3571–81.
• Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human beta Cell Function Arda, H. E., Li, L., Tsai, J., Torre, E. A., Rosli, Y., Peiris, H., … Kim, S. K. (2016). Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human beta Cell Function. CELL METABOLISM , 23 (5), 909–20.
• Decoding the RNA structurome Lu, Z., & Chang, H. Y. (2016). Decoding the RNA structurome. CURRENT OPINION IN STRUCTURAL BIOLOGY , 36 , 142–48.
• A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63. Bao, X., Rubin, A. J., Qu, K., Zhang, J., Giresi, P. G., Chang, H. Y., & Khavari, P. A. (2015). A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63. Genome Biology , 16 (1), 284-?
• 7SK-BAF axis controls pervasive transcription at enhancers. Flynn, R. A., Do, B. T., Rubin, A. J., Calo, E., Lee, B., Kuchelmeister, H., … Chang, H. Y. (2016). 7SK-BAF axis controls pervasive transcription at enhancers. Nature Structural & Molecular Biology , 23 (3), 231–38.
• Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE. Flynn, R. A., Zhang, Q. C., Spitale, R. C., Lee, B., Mumbach, M. R., & Chang, H. Y. (2016). Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE. Nature Protocols , 11 (2), 273–90.
• Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace Qu, K., Garamszegi, S., Wu, F., Thorvaldsdottir, H., Liefeld, T., Ocana, M., … Mesirov, J. P. (2016). Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace. NATURE METHODS , 13 (3), 245-?
• Rapid evolutionary turnover underlies conserved lncRNA-genome interactions Quinn, J. J., Zhang, Q. C., Georgiev, P., Ilik, I. A., Akhtar, A., & Change, H. Y. (2016). Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. GENES & DEVELOPMENT , 30 (2), 191–207.
• Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation. Mazumdar, C., Shen, Y., Xavy, S., Zhao, F., Reinisch, A., Li, R., … Majeti, R. (2015). Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation. Cell Stem Cell , 17 (6), 675–88.
• Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Tan, J. L., Fogley, R. D., Flynn, R. A., Ablain, J., Yang, S., Saint-André, V., … Zon, L. I. (2016). Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molecular Cell , 62 (1), 34–46.
• Unique features of long non-coding RNA biogenesis and function. Quinn, J. J., & Chang, H. Y. (2015). Unique features of long non-coding RNA biogenesis and function. Nature Reviews. Genetics , 17 (1), 47–62.
• Decoding the RNA structurome. Lu, Z., & Chang, H. Y. (2016). Decoding the RNA structurome. Current Opinion in Structural Biology , 36 , 142–48.
• Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress Oh, S., Flynn, R. A., Floor, S. N., Purzner, J., Martin, L., Do, B. T., … Cho, Y.-J. (2016). Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. ONCOTARGET , 7 (19), 28169–82.
• Single-cell profiling of lncRNAs in the developing human brain Ma, Q., & Chang, H. Y. (2016). Single-cell profiling of lncRNAs in the developing human brain. GENOME BIOLOGY , 17 .
• A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation Atianand, M. K., Hu, W., Satpathy, A. T., Shen, Y., Ricci, E. P., Alvarez-Dominguez, J. R., … Fitzgerald, K. A. (2016). A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation. CELL , 165 (7), 1672–85.
• irCLIP platform for efficient characterization of protein-RNA interactions Zarnegar, B. J., Flynn, R. A., Shen, Y., Do, B. T., Chang, H. Y., & Khavari, P. A. (2016). irCLIP platform for efficient characterization of protein-RNA interactions. NATURE METHODS , 13 (6), 489-?
• An inducible long noncoding RNA amplifies DNA damage signaling. Schmitt, A. M., Garcia, J. T., Hung, T., Flynn, R. A., Shen, Y., Qu, K., … Chang, H. Y. (2016). An inducible long noncoding RNA amplifies DNA damage signaling. Nature Genetics , 48 (11), 1370–76.
• lncRNA Structure: Message to the Heart. Fazal, F. M., & Chang, H. Y. (2016). lncRNA Structure: Message to the Heart. Molecular Cell , 64 (1), 1–2.
• Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Huang, W.-H., Guenthner, C. J., Xu, J., Nguyen, T., Schwarz, L. A., Wilkinson, A. W., … Luo, L. (2016). Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron , 92 (2), 392–406.
• HiChIP: efficient and sensitive analysis of protein-directed genome architecture. Mumbach, M. R., Rubin, A. J., Flynn, R. A., Dai, C., Khavari, P. A., Greenleaf, W. J., & Chang, H. Y. (2016). HiChIP: efficient and sensitive analysis of protein-directed genome architecture. Nature Methods , 13 (11), 919–22.
• Structural organization of the inactive X chromosome in the mouse Giorgetti, L., Lajoie, B. R., Carter, A. C., Attia, M., Zhan, Y., Xu, J., … Dekker, J. (2016). Structural organization of the inactive X chromosome in the mouse. NATURE , 535 (7613), 575-?
• HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells Sadik, H., Korangath, P., Nguyen, N. K., Gyorffy, B., Kumar, R., Hedayati, M., … Sukumar, S. (2016). HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells. CANCER RESEARCH , 76 (15), 4443–56.
• Individuality and variation of personal regulomes in primary human T cells. Qu, K., Zaba, L. C., Giresi, P. G., Li, R., Longmire, M., Kim, Y. H., … Chang, H. Y. (2015). Individuality and variation of personal regulomes in primary human T cells. Cell Systems , 1 (1), 51–61.
• ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing. Chen, X., Shen, Y., Draper, W., Buenrostro, J. D., Litzenburger, U., Cho, S. W., … Chang, H. Y. (2016). ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing. Nature Methods .
• Single-cell epigenomic variability reveals functional cancer heterogeneity. Litzenburger, U. M., Buenrostro, J. D., Wu, B., Shen, Y., Sheffield, N. C., Kathiria, A., … Chang, H. Y. (2017). Single-cell epigenomic variability reveals functional cancer heterogeneity. Genome Biology , 18 (1), 15-?
• Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells. Xu, J., Carter, A. C., Gendrel, A.-V., Attia, M., Loftus, J., Greenleaf, W. J., … Chang, H. Y. (2017). Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells. Nature Genetics , 49 (3), 377–86.
• Individuality and Variation of Personal Regulomes in Primary Human T Cells Qu, K., Zaba, L. C., Giresi, P. G., Li, R., Longmire, M., Kim, Y. H., … Chang, H. Y. (2015). Individuality and Variation of Personal Regulomes in Primary Human T Cells. CELL SYSTEMS , 1 (1), 51–61.
• Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing Xu, J., Spitale, R. C., Guan, L., Flynn, R. A., Torre, E. A., Li, R., … Chang, A. L. S. (2016). Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PLOS ONE , 11 (11).
• Comparison of SHAPE reagents for mapping RNA structures inside living cells Lee, B., Flynn, R. A., Kadina, A., Guo, J. K., Kool, E. T., & Chang, H. Y. (2017). Comparison of SHAPE reagents for mapping RNA structures inside living cells. RNA , 23 (2), 169–74.
• Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. Xu, J., Spitale, R. C., Guan, L., Flynn, R. A., Torre, E. A., Li, R., … Chang, A. L. S. (2016). Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PloS One , 11 (11).
• Gpr124 is essential for blood-brain barrier integrity in central nervous system disease Chang, J., Mancuso, M. R., Maier, C., Liang, X., Yuki, K., Yang, L., … Kuo, C. J. (2017). Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. NATURE MEDICINE , 23 (4), 450-?
• The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Simsek, D., Tiu, G. C., Flynn, R. A., Byeon, G. W., Leppek, K., Xu, A. F., … Barna, M. (2017). The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Cell , 169 (6), 1051–65 e18.
• Generation of pure GABAergic neurons by transcription factor programming. Yang, N., Chanda, S., Marro, S., Ng, Y.-H., Janas, J. A., Haag, D., … Wernig, M. (2017). Generation of pure GABAergic neurons by transcription factor programming. Nature Methods , 14 (6), 621–28.
• Chromatin Accessibility Landscape of Cutaneous T Cell Lymphoma and Dynamic Response to HDAC Inhibitors. Qu, K., Zaba, L. C., Satpathy, A. T., Giresi, P. G., Li, R., Jin, Y., … Chang, H. Y. (2017). Chromatin Accessibility Landscape of Cutaneous T Cell Lymphoma and Dynamic Response to HDAC Inhibitors. Cancer Cell .
• Sensing Self and Foreign Circular RNAs by Intron Identity. Chen, Y. G., Kim, M. V., Chen, X., Batista, P. J., Aoyama, S., Wilusz, J. E., … Chang, H. Y. (2017). Sensing Self and Foreign Circular RNAs by Intron Identity. Molecular Cell .
• Gene regulation in the immune system by long noncoding RNAs. Chen, Y. G., Satpathy, A. T., & Chang, H. Y. (2017). Gene regulation in the immune system by long noncoding RNAs. Nature Immunology , 18 (9), 962–72.
• An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Corces, M. R., Trevino, A. E., Hamilton, E. G., Greenside, P. G., Sinnott-Armstrong, N. A., Vesuna, S., … Chang, H. Y. (2017). An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nature Methods .
• Discovery of stimulation-responsive immune enhancers with CRISPR activation. Simeonov, D. R., Gowen, B. G., Boontanrart, M., Roth, T. L., Gagnon, J. D., Mumbach, M. R., … Marson, A. (2017). Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature .
• Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements. Mumbach, M. R., Satpathy, A. T., Boyle, E. A., Dai, C., Gowen, B. G., Cho, S. W., … Chang, H. Y. (2017). Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements. Nature Genetics .
• Genome-Wide Temporal Profiling of Transcriptome and Open Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs. Liu, Q., Jiang, C., Xu, J., Zhao, M.-T. T., Van Bortle, K., Cheng, X., … Snyder, M. P. (2017). Genome-Wide Temporal Profiling of Transcriptome and Open Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs. Circulation Research , 121 (4), 376–91.
• Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation. Rubin, A. J., Barajas, B. C., Furlan-Magaril, M., Lopez-Pajares, V., Mumbach, M. R., Howard, I., … Khavari, P. A. (2017). Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation. Nature Genetics , 49 (10), 1522–28.
• Factors That May Promote an Effective Local Research Environment Wang, K., Lee, C. S., Marinkovich, M. P., Chang, H. Y., Oro, A. E., & Khavari, P. A. (2016). Factors That May Promote an Effective Local Research Environment. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 136 (8), 1529–31.
• Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia Corces, M. R., Chang, H. Y., & Majeti, R. (2017). Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia. FRONTIERS IN ONCOLOGY , 7 , 263.
• m(6)A mRNA methylation sustains Treg suppressive functions Tong, J., Cao, G., Zhang, T., Sefik, E., Vesely, M. C. A., Broughton, J. P., … Li, H.-B. (2018). m(6)A mRNA methylation sustains Treg suppressive functions. CELL RESEARCH , 28 (2), 253–56.
• Challenges and recommendations for epigenomics in precision health Carter, A. C., Chang, H. Y., Church, G., Dombkowski, A., Ecker, J. R., Gil, E., … Wong, W. (2017). Challenges and recommendations for epigenomics in precision health. NATURE BIOTECHNOLOGY , 35 (12), 1128–32.
• Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin. Satpathy, A. T., Brown, R. A., Gomulia, E., Briseño, C. G., Mumbach, M. R., Pan, Z., … Kim, J. (2018). Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc .
• IL-4R alpha Inhibitor for Atopic Disease Chang, H. Y., & Nadeau, K. C. (2017). IL-4R alpha Inhibitor for Atopic Disease. CELL , 170 (2), 222.
• Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation Mazumdar, C., Shen, Y., Xavy, S., Zhao, F., Reinisch, A., Li, R., … Majeti, R. (2015). Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation. BLOOD . AMER SOC HEMATOLOGY.
• An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. Chen, L., Roake, C. M., Freund, A., Batista, P. J., Tian, S., Yin, Y. A., … Artandi, S. E. (2018). An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. Cell .
• GENOMIC AND EPIGENOMIC ANALYSIS OF ENGRAILED-1 FIBROBLASTS PREDICT FIBROGENIC ROLE IN SCARRING Hu, M. S., Walmsley, G., Leavitt, T., Litzenburger, U., Marshall, C., Sinha, R., … Longaker, M. (2017). GENOMIC AND EPIGENOMIC ANALYSIS OF ENGRAILED-1 FIBROBLASTS PREDICT FIBROGENIC ROLE IN SCARRING. WOUND REPAIR AND REGENERATION . WILEY.
• Prrx1 Labels the Fibrogenic Fibroblast in the Ventral Dermis Hu, M., Leavitt, T., Garcia, J., Ransom, R., Litzenburger, U., Walmsley, G., … Longaker, M. (2018). Prrx1 Labels the Fibrogenic Fibroblast in the Ventral Dermis. WOUND REPAIR AND REGENERATION . WILEY.
• Epigenetic Analysis of Scar Forming Fibroblasts Reveals Key Differences in Genes Associated with Fibrosis Moore, A. L., Marshall, C. D., Litzenburger, U., Barnes, L., Ransom, R. C., Hu, M., … Longaker, M. T. (2017). Epigenetic Analysis of Scar Forming Fibroblasts Reveals Key Differences in Genes Associated with Fibrosis. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS . ELSEVIER SCIENCE INC.
• The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline Bailey, A. S., Batista, P. J., Gold, R. S., Chen, Y. G., de Rooij, D. G., Chang, H. Y., & Fuller, M. T. (2017). The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline. ELIFE , 6 .
• Rapid chromatin repression by Aire provides precise control of immune tolerance Koh, A. S., Miller, E. L., Buenrostro, J. D., Moskowitz, D. M., Wang, J., Greenleaf, W. J., … Crabtree, G. R. (2018). Rapid chromatin repression by Aire provides precise control of immune tolerance. NATURE IMMUNOLOGY , 19 (2), 162-+.
• Decoding regulatory sequence across skin differentiation with deep learning Kim, D., Risca, V., Chappell, J., Shi, M., Zhao, Z., Jung, N., … Khavari, P. (2018). Decoding regulatory sequence across skin differentiation with deep learning. JOURNAL OF INVESTIGATIVE DERMATOLOGY . ELSEVIER SCIENCE INC.
• Dynamic morphogen-p63 chromatin interactions that guide epigenetic changes and p63 activity in surface ectoderm commitment Pattison, J., Melo, S., Piekos, S., Torkelson, J., Mumbach, M. R., Rubin, A., … Oro, A. E. (2018). Dynamic morphogen-p63 chromatin interactions that guide epigenetic changes and p63 activity in surface ectoderm commitment. JOURNAL OF INVESTIGATIVE DERMATOLOGY . ELSEVIER SCIENCE INC.
• Mechanistic insights in X-chromosome inactivation. Lu, Z., Carter, A. C., & Chang, H. Y. (2017). Mechanistic insights in X-chromosome inactivation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences , 372 (1733).
• Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cho, S. W., Xu, J., Sun, R., Mumbach, M. R., Carter, A. C., Chen, Y. G., … Chang, H. Y. (2018). Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell , 173 (6), 1398.
• Epigenomics: Technologies and Applications. Wang, K. C., & Chang, H. Y. (2018). Epigenomics: Technologies and Applications. Circulation Research , 122 (9), 1191–99.
• Enhancer connectome functionally interrogates GWAS-identified intergenic SNPs associated with inflammatory skin conditions Jeng, M. Y., Mumbach, M. R., Granja, J. M., Satpathy, A. T., Chang, H., & Chang, A. (2018). Enhancer connectome functionally interrogates GWAS-identified intergenic SNPs associated with inflammatory skin conditions. JOURNAL OF INVESTIGATIVE DERMATOLOGY . ELSEVIER SCIENCE INC.
• Transcription coactivator and lncRNA duet evoke Hox genes Wang, K. C., & Chang, H. Y. (2017). Transcription coactivator and lncRNA duet evoke Hox genes. PLOS GENETICS , 13 (6), e1006797.
• m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways Li, H.-B., Tong, J., Zhu, S., Batista, P. J., Duffy, E. E., Zhao, J., … Flavell, R. A. (2017). m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. NATURE , 548 (7667), 338-+.
• ATAC Primer Tool for targeted analysis of accessible chromatin Yost, K. E., Carter, A. C., Xu, J., Litzenburger, U., & Chang, H. Y. (2018). ATAC Primer Tool for targeted analysis of accessible chromatin. NATURE METHODS , 15 (5), 304–5.
• In Situ Imaging of Spatial Organization of Accessible Chromatin at the Nanoscale with ATAC-see and Single-Molecule Super-Resolution Fluorescence Microscopy Lee, M. Y., Chen, X., Gustavsson, A.-K., Chang, H. Y., & Moerner, W. E. (2018). In Situ Imaging of Spatial Organization of Accessible Chromatin at the Nanoscale with ATAC-see and Single-Molecule Super-Resolution Fluorescence Microscopy. BIOPHYSICAL JOURNAL . CELL PRESS.
• LncRNA Seduction of GOT2 Goes Viral Chen, Y. G., & Chang, H. Y. (2017). LncRNA Seduction of GOT2 Goes Viral. IMMUNITY , 47 (6), 1021–23.
• Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology Schmitt, A. M., & Chang, H. Y. (2017). Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE , 7 (7).
• Transforming Growth Factor Beta 3 (TGFB3) - a Novel Systemic Sclerosis Susceptibility Locus Involved in Fibrosis and Th17 Cell Development Identified By Genome-Wide Association Study in African Americans from the Genome Research in African American Scleroderma Patients Consortium Gourh, P., Remmers, E. F., Satpathy, A., Boyden, S., Morgan, N. D., Shah, A. A., … Kastner, D. L. (2017). Transforming Growth Factor Beta 3 (TGFB3) - a Novel Systemic Sclerosis Susceptibility Locus Involved in Fibrosis and Th17 Cell Development Identified By Genome-Wide Association Study in African Americans from the Genome Research in African American Scleroderma Patients Consortium. ARTHRITIS & RHEUMATOLOGY . WILEY.
• Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation Buenrostro, J. D., Corces, M. R., Lareau, C. A., Wu, B., Schep, A. N., Aryee, M. J., … Greenleaf, W. J. (2018). Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation. CELL , 173 (6), 1535-+.
• Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations. Duren, Z., Chen, X., Zamanighomi, M., Zeng, W., Satpathy, A. T., Chang, H. Y., … Wong, W. H. (2018). Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations. Proceedings of the National Academy of Sciences of the United States of America .
• SYSTEMATIC IDENTIFICATION OF ESSENTIAL LONG NON-CODING RNA GENES IN GLIOBLASTOMA Liu, S., Horlbeck, M., Cho, S. W., Birk, H., Malatesta, M., He, D., … Lim, D. (2016). SYSTEMATIC IDENTIFICATION OF ESSENTIAL LONG NON-CODING RNA GENES IN GLIOBLASTOMA. NEURO-ONCOLOGY . OXFORD UNIV PRESS INC.
• Long Non-Coding RNA Expression Levels Correlate with Proliferation Index in Breast Carcinoma. Chisholm, K. M., Li, R., Wan, Y., Chang, H. Y., & West, R. B. (2011). Long Non-Coding RNA Expression Levels Correlate with Proliferation Index in Breast Carcinoma. MODERN PATHOLOGY . NATURE PUBLISHING GROUP.
• Long Non-Coding RNA and Polycomb Protein Expression Levels Are Increased in Metastatic Versus Primary Breast Carcinoma Chisholm, K. M., Li, R., Wan, Y., Chang, H., & West, R. B. (2012). Long Non-Coding RNA and Polycomb Protein Expression Levels Are Increased in Metastatic Versus Primary Breast Carcinoma. MODERN PATHOLOGY . NATURE PUBLISHING GROUP.
• Long Non-Coding RNA and Polycomb Protein Expression Levels Are Increased in Metastatic Versus Primary Breast Carcinoma Chisholm, K. M., Li, R., Wan, Y., Chang, H., & West, R. B. (2012). Long Non-Coding RNA and Polycomb Protein Expression Levels Are Increased in Metastatic Versus Primary Breast Carcinoma. LABORATORY INVESTIGATION . NATURE PUBLISHING GROUP.
• Long Non-Coding RNA Expression Levels Correlate with Proliferation Index in Breast Carcinoma Chisholm, K. M., Li, R., Wan, Y., Chang, H. Y., & West, R. B. (2011). Long Non-Coding RNA Expression Levels Correlate with Proliferation Index in Breast Carcinoma. LABORATORY INVESTIGATION . NATURE PUBLISHING GROUP.
• Understanding RNA-Chromatin Interactions Using Chromatin Isolation by RNA Purification (ChIRP) Chu, C., & Chang, H. Y. (2016). Understanding RNA-Chromatin Interactions Using Chromatin Isolation by RNA Purification (ChIRP). POLYCOMB GROUP PROTEINS: METHODS AND PROTOCOLS , 1480 , 115–23.
• Genetic determinants of co-accessible chromatin regions in activated T cells across humans Gate, R. E., Cheng, C. S., Aiden, A. P., Siba, A., Tabaka, M., Lituiev, D., … Regev, A. (2018). Genetic determinants of co-accessible chromatin regions in activated T cells across humans. NATURE GENETICS , 50 (8), 1140-+.
• A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas. Arda, H. E., Tsai, J., Rosli, Y. R., Giresi, P., Bottino, R., Greenleaf, W. J., … Kim, S. K. (2018). A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas. Cell Systems .
• Gender and Gene Regulation in Human Immunity Longmire, M. R., & Chang, H. (2017). Gender and Gene Regulation in Human Immunity. PRINCIPLES OF GENDER-SPECIFIC MEDICINE: GENDER IN THE GENOMIC ERA, 3RD EDITION , 335–40.
• ChIRP-MS: RNA-Directed Proteomic Discovery. Chu, C., & Chang, H. Y. (2018). ChIRP-MS: RNA-Directed Proteomic Discovery. Methods in Molecular Biology (Clifton, N.J.) , 1861 , 37–45.
• Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons Wapinski, O. L., Lee, Q. Y., Chen, A. C., Li, R., Corces, M. R., Ang, C. E., … Chang, H. Y. (2017). Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons. CELL REPORTS , 20 (13), 3236–47.
• Neurogenic lncRNAs mutated in human neurodevelopmental disorders. Ang, C., Wapinski, O., Ma, Q., Fan, S., Flynn, R. A., Coe, B., … Wernig, M. (2016). Neurogenic lncRNAs mutated in human neurodevelopmental disorders. MOLECULAR BIOLOGY OF THE CELL . AMER SOC CELL BIOLOGY.
• Epidermal tissue differentiation and lipid barrier function requires the long non-coding RNA Linc19A Kretz, M., Webster, D., Siprashvili, Z., Zehnder, A., Lee, C., Flockhart, R., … Khavari, P. (2011). Epidermal tissue differentiation and lipid barrier function requires the long non-coding RNA Linc19A. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• Identification of the Human Skeletal Stem Cell. Chan, C. K., Gulati, G. S., Sinha, R., Tompkins, J. V., Lopez, M., Carter, A. C., … Longaker, M. T. (2018). Identification of the Human Skeletal Stem Cell. Cell , 175 (1), 43.
• Transposition of Native Chromatin for Fast and Sensitive Mulitmodal Analysis of Chromatin Architecture Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2014). Transposition of Native Chromatin for Fast and Sensitive Mulitmodal Analysis of Chromatin Architecture. BIOPHYSICAL JOURNAL . CELL PRESS.
• Enhancer connectome nominates target genes of inherited risk variants from inflammatory skin disorders. Jeng, M. Y., Mumbach, M. R., Granja, J. M., Satpathy, A. T., Chang, H. Y., & Chang, A. L. (2018). Enhancer connectome nominates target genes of inherited risk variants from inflammatory skin disorders. The Journal of Investigative Dermatology .
• DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Retraction of Vol 528, Pg 517, 2015) Huang, W., Thomas, B., Flynn, R. A., Gavzy, S. J., Wu, L., Kim, S. V., … Littman, D. R. (2018). DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Retraction of Vol 528, Pg 517, 2015). NATURE , 562 (7725), 150.
• Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders Calo, E., Gu, B., Bowen, M. E., Aryan, F., Zalc, A., Liang, J., … Wysocka, J. (2018). Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. NATURE , 554 (7690), 112-+.
• Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Ransom, R. C., Carter, A. C., Salhotra, A., Leavitt, T., Marecic, O., Murphy, M. P., … Longaker, M. T. (2018). Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature .
• The chromatin accessibility landscape of primary human cancers. Corces, M. R., Granja, J. M., Shams, S., Louie, B. H., Seoane, J. A., Zhou, W., … Chang, H. Y. (2018). The chromatin accessibility landscape of primary human cancers. Science (New York, N.Y.) , 362 (6413).
• Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. Chen, X., Litzenburger, U. M., Wei, Y., Schep, A. N., LaGory, E. L., Choudhry, H., … Chang, H. Y. (2018). Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. Nature Communications , 9 (1), 4590.
• Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Pattison, J. M., Melo, S. P., Piekos, S. N., Torkelson, J. L., Bashkirova, E., Mumbach, M. R., … Oro, A. E. (2018). Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Nature Genetics .
• Discovery of stimulation-responsive immune enhancers with CRISPR activation (vol 549, pg 111, 2017) Simeonov, D. R., Gowen, B. G., Boontanrart, M., Roth, T. L., Gagnon, J. D., Mumbach, M. R., … Marson, A. (2018). Discovery of stimulation-responsive immune enhancers with CRISPR activation (vol 549, pg 111, 2017). NATURE , 559 (7715), E13.
• The RNA Base-Pairing Problem and Base-Pairing Solutions. Lu, Z., & Chang, H. Y. (2018). The RNA Base-Pairing Problem and Base-Pairing Solutions. Cold Spring Harbor Perspectives in Biology , 10 (12).
• Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks. Rubin, A. J., Parker, K. R., Satpathy, A. T., Qi, Y., Wu, B., Ong, A. J., … Khavari, P. A. (2018). Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks. Cell .
• Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons. Luo, C., Lee, Q. Y., Wapinski, O., Castanon, R., Nery, J. R., Mall, M., … Ecker, J. R. (2019). Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons. ELife , 8 .
• TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. Li, L., Wang, Y., Torkelson, J. L., Shankar, G., Pattison, J. M., Zhen, H. H., … Oro, A. E. (2019). TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. Cell Stem Cell .
• A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Van Gool, F., Nguyen, M. L., Mumbach, M. R., Satpathy, A. T., Rosenthal, W. L., Giacometti, S., … Bluestone, J. A. (2019). A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Immunity .
• Long Noncoding RNA and Its Role in the Control of Gene Expression in the Skin Wang, K. C., & Chang, H. Y. (2018). Long Noncoding RNA and Its Role in the Control of Gene Expression in the Skin. EPIGENETIC REGULATION OF SKIN DEVELOPMENT AND REGENERATION , 197–213.
• Invariant Natural Killer T Cell Subsets Have Diverse Functions: iNKT2 and iNKT17 Protect from Graft-Versus-Host-Disease, Whereas iNKT1 Have Antitumor Potential Maas-Bauer, K., Simonetta, F., Hirai, T., Wenokur, A., Fazal, F., Kambham, N., … Negrin, R. S. (2018). Invariant Natural Killer T Cell Subsets Have Diverse Functions: iNKT2 and iNKT17 Protect from Graft-Versus-Host-Disease, Whereas iNKT1 Have Antitumor Potential. BLOOD . AMER SOC HEMATOLOGY.
• Foxp3 domain-swap interface is required to suppress T helper type 2 transcriptional program in Regulatory T cells. Van Gool, F., Nguyen, M. L., Mumbach, M. R., Satpathy, A. T., Anderson, M. S., Marson, A., … Bluestone, J. A. (2018). Foxp3 domain-swap interface is required to suppress T helper type 2 transcriptional program in Regulatory T cells. JOURNAL OF IMMUNOLOGY . AMER ASSOC IMMUNOLOGISTS.
• RNA structure maps across mammalian cellular compartments. Sun, L., Fazal, F. M., Li, P., Broughton, J. P., Lee, B., Tang, L., … Zhang, Q. C. (2019). RNA structure maps across mammalian cellular compartments. Nature Structural & Molecular Biology .
• Dynamic and stable enhancer-promoter contacts regulate epidermal terminal differentiation Lopez-Pajares, V., Rubin, A., Barajas, B., Furlan-Magaril, M., Mumbach, M., Greenleaf, W., … Khavari, P. A. (2017). Dynamic and stable enhancer-promoter contacts regulate epidermal terminal differentiation. JOURNAL OF INVESTIGATIVE DERMATOLOGY . ELSEVIER SCIENCE INC.
• The BAF/SWI/SNF complex controls genome accessibility to p63 during epidermal differentiation Bao, X., Rubin, A., Qu, K., Zhang, J., Giresi, P., Chang, H., & Khavari, P. (2015). The BAF/SWI/SNF complex controls genome accessibility to p63 during epidermal differentiation. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• Reversal of epidermal aging by NF-kappa B blockade Adler, A. S., Kawahara, T. L., Zhang, J. Y., Segal, E., Chua, K. F., & Chang, H. Y. (2008). Reversal of epidermal aging by NF-kappa B blockade. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• Site-specific induction of epidermal fates by dermal HOX transcriptional program Rinn, J. L., Wang, J. K., Allen, N., Mikels, A. J., Nusse, R., Helms, J. A., & Chang, H. Y. (2007). Site-specific induction of epidermal fates by dermal HOX transcriptional program. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• Asymmetric regulation of gene expression in the response of fibroblasts to serum deprivation Liu, H., Segal, E., & Chang, H. Y. (2006). Asymmetric regulation of gene expression in the response of fibroblasts to serum deprivation. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• Gene-expression profiling of lesional and atopy patched tested skin in patients with atopic dermatitis using cDNA microarrays Saaf, A., Bradley, M., Tengvall-Linder, M., Chang, H. Y., Wahlgren, C. F., Scheynius, A., … Brown, P. O. (2005). Gene-expression profiling of lesional and atopy patched tested skin in patients with atopic dermatitis using cDNA microarrays. JOURNAL OF INVESTIGATIVE DERMATOLOGY . ELSEVIER SCIENCE INC.
• Molecular anatomy of human fibroblast diversity Rinn, J. L., Bondre, C., van De Rijn, M., Brown, P., & Chang, H. Y. (2005). Molecular anatomy of human fibroblast diversity. JOURNAL OF INVESTIGATIVE DERMATOLOGY . BLACKWELL PUBLISHING INC.
• Reproducibility of several gene expression signatures in predicting outcome in breast cancer Nuyten, D. S., Chang, H. Y., Sneddon, J. B., Hart, G. A., van 't Veer, L. J., Peterse, H. L., … van de Vijver, M. J. (2004). Reproducibility of several gene expression signatures in predicting outcome in breast cancer. BREAST CANCER RESEARCH AND TREATMENT . SPRINGER.
• Finding specific drug targets by applying gene module analysis in patients categorized by previously established prognostic gene expression signature in early stage breast cancer. Nuyten, D. S., Lin, M., Adler, A. A., Bartelink, H., Van de Vijver, M. J., & Chang, H. Y. (2006). Finding specific drug targets by applying gene module analysis in patients categorized by previously established prognostic gene expression signature in early stage breast cancer. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Genome Regulation by Long Noncoding RNAs Chang, H. Y. (2016). Genome Regulation by Long Noncoding RNAs. FASEB JOURNAL . FEDERATION AMER SOC EXP BIOL.
• Comment on "Hotair Is Dispensable for Mouse Development" Li, L., Helms, J. A., & Chang, H. Y. (2016). Comment on "Hotair Is Dispensable for Mouse Development". PLOS GENETICS , 12 (12), e1006406.
• Analysis Of T Helper Cell Gene Regulation In Asthma By Genome-Wide Chromatin Accessibility Profiling In Monozygotic Twins Bauer, R. N., Satpathy, A. T., Qu, K., Ho, T., Chinthrajah, R. S., Miller, R. L., … Nadeau, K. C. (2016). Analysis Of T Helper Cell Gene Regulation In Asthma By Genome-Wide Chromatin Accessibility Profiling In Monozygotic Twins. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . AMER THORACIC SOC.
• Genome regulation by long noncoding RNAs Chang, H. Y. (2016). Genome regulation by long noncoding RNAs. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• The Homeobox Protein H0XC10 Is Overexpressed in Breast Cancer and Confers Resistance to Chemotherapy Sadik, H., Shah, N., Gupta, R. A., Chang, H. Y., & Sukumar, S. (2010). The Homeobox Protein H0XC10 Is Overexpressed in Breast Cancer and Confers Resistance to Chemotherapy. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Long Noncoding RNAs in Breast Cancer Progression Chang, H. Y. (2010). Long Noncoding RNAs in Breast Cancer Progression. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Tumor as wound: gene expression signature of fibroblast serum response predicts human cancer progression Chang, H. Y., Sneddon, J. B., van de Rijn, M., & Brown, P. O. (2004). Tumor as wound: gene expression signature of fibroblast serum response predicts human cancer progression. JOURNAL OF INVESTIGATIVE DERMATOLOGY . BLACKWELL PUBLISHING INC.
• LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes Carlson, H. L., Quinn, J. J., Yang, Y. W., Thornburg, C. K., Chang, H. Y., & Stadler, H. S. (2015). LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes. PLOS GENETICS , 11 (12), e1005680.
• Genome-Wide Probing of RNA Structures In Vitro Using Nucleases and Deep Sequencing. Wan, Y., Qu, K., Ouyang, Z., & Chang, H. Y. (2016). Genome-Wide Probing of RNA Structures In Vitro Using Nucleases and Deep Sequencing. Methods in Molecular Biology (Clifton, N.J.) , 1361 , 141–60.
• Hyaluronan synthase 2 antisense transcript level associates with human skin youthfulness as identified by transcriptome sequencing Xu, J., Flynn, R. A., Spitale, R., Torre, E., Li, R., Kern, D. G., … Chang, A. S. (2015). Hyaluronan synthase 2 antisense transcript level associates with human skin youthfulness as identified by transcriptome sequencing. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• Montagna Symposium 2014-Skin Aging: Molecular Mechanisms and Tissue Consequences Gilchrest, B. A., Campisi, J., Chang, H. Y., Fisher, G. J., & Kulesz-Martin, M. F. (2015). Montagna Symposium 2014-Skin Aging: Molecular Mechanisms and Tissue Consequences. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 135 (4), 950–53.
• Cohesin Complex Mutations Impair Differentiation of Human Hematopoietic Stem and Progenitor Cells Mazumdar, C., Li, R., Buenrostro, J., Chang, H. Y., & Majeti, R. (2014). Cohesin Complex Mutations Impair Differentiation of Human Hematopoietic Stem and Progenitor Cells. BLOOD . AMER SOC HEMATOLOGY.
• PALMOPLANTAR SPECIFIC LONG NCRNA HOTAIR DRIVES MYOFIBROBLASTS SPECIFIC SIGNATURE IN SYSTEMIC SCLEROSIS Abignano, G., Hermes, H., Esteves, F., Gillespie, J., Chang, H. Y., Jimenez, S. A., … Del Galdo, F. (2013). PALMOPLANTAR SPECIFIC LONG NCRNA HOTAIR DRIVES MYOFIBROBLASTS SPECIFIC SIGNATURE IN SYSTEMIC SCLEROSIS. ANNALS OF THE RHEUMATIC DISEASES . BMJ PUBLISHING GROUP.
• Epigenomic maps in faithful tissue context of skin cell types Zaba, L., Longmire, M., Zhang, J., & Chang, H. Y. (2014). Epigenomic maps in faithful tissue context of skin cell types. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• Genome regulation by long noncoding RNAs Chang, H. Y. (2013). Genome regulation by long noncoding RNAs. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Regulation of the DNA Damage Response by an Inducible Long Noncoding RNA Schmitt, A., Hung, T., Flynn, R., Payumo, A., Peres-da-Silva, A., Broz, D. K., … Chang, H. (2013). Regulation of the DNA Damage Response by an Inducible Long Noncoding RNA. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS . ELSEVIER SCIENCE INC.
• GENE REGULATION Long RNAs wire up cancer growth Schmitt, A. M., & Chang, H. Y. (2013). GENE REGULATION Long RNAs wire up cancer growth. NATURE , 500 (7464), 536–37.
• Sustained beta-catenin activity leads to dermal fibrosis by promoting expression of various pro-fibrotic mediators Hamburg, E., Chen, D., Torres, E., Chang, H., & Atit, R. (2013). Sustained beta-catenin activity leads to dermal fibrosis by promoting expression of various pro-fibrotic mediators. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• The transcription factor ZNF217 is an oncogene that promotes an increase in progenitor cells, increases metastasis, and acts via the AKT pathway Littlepage, L. E., Kouros-Mehr, H., Adler, A. S., Chou, J., Huang, G., Collins, C. C., … Werb, Z. (2011). The transcription factor ZNF217 is an oncogene that promotes an increase in progenitor cells, increases metastasis, and acts via the AKT pathway. MOLECULAR BIOLOGY OF THE CELL . AMER SOC CELL BIOLOGY.
• Rejuvenation of gene expression patterns in aged human skin with broadband light treatment Chang, A. S., Bitter, P., Qu, K., & Chang, H. Y. (2012). Rejuvenation of gene expression patterns in aged human skin with broadband light treatment. JOURNAL OF INVESTIGATIVE DERMATOLOGY . NATURE PUBLISHING GROUP.
• Microarray Analysis of Stem Cells and Differentiation Chang, H. Y., & Chen, X. (2009). Microarray Analysis of Stem Cells and Differentiation. ESSENTIALS OF STEM CELL BIOLOGY, 2ND EDITION , 449–57.
• Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA. Xu, J., Nuno, K., Litzenburger, U. M., Qi, Y., Corces, M. R., Majeti, R., & Chang, H. Y. (2019). Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA. ELife , 8 .
• Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oh, S., Flynn, R. A., Floor, S. N., Purzner, J., Martin, L., Do, B. T., … Cho, Y.-J. J. (2016). Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget , 7 (19), 28169–82.
• Long noncoding RNA in hematopoiesis and immunity. Satpathy, A. T., & Chang, H. Y. (2015). Long noncoding RNA in hematopoiesis and immunity. Immunity , 42 (5), 792–804.
• Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA Xu, J., Nuno, K., Litzenburger, U. M., Qi, Y., Corces, M. R., Majeti, R., & Chang, H. Y. (2019). Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA. ELIFE , 8 .
• Identification of the Human Skeletal Stem Cell Chan, C. K. F., Gulati, G. S., Sinha, R., Tompkins, J. V., Lopez, M., Carter, A. C., … Longaker, M. T. (2018). Identification of the Human Skeletal Stem Cell. CELL , 175 (1), 43-+.
• RNA structure maps across mammalian cellular compartments Sun, L., Fazal, F. M., Li, P., Broughton, J. P., Lee, B., Tang, L., … Zhang, Q. C. (2019). RNA structure maps across mammalian cellular compartments. NATURE STRUCTURAL & MOLECULAR BIOLOGY , 26 (4), 322-+.
• Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks Rubin, A. J., Parker, K. R., Satpathy, A. T., Qi, Y., Wu, B., Ong, A. J., … Khavari, P. A. (2019). Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks. CELL , 176 (1-2), 361-+.
• Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration Ransom, R. C., Carter, A. C., Salhotra, A., Leavitt, T., Marecic, O., Murphy, M. P., … Longaker, M. T. (2018). Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. NATURE , 563 (7732), 514-+.
• ChIRP-MS: RNA-Directed Proteomic Discovery Chu, C., & Chang, H. Y. (2018). ChIRP-MS: RNA-Directed Proteomic Discovery. X-CHROMOSOME INACTIVATION: METHODS AND PROTOCOLS , 1861 , 37–45.
• Promoter of IncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element Cho, S. W., Xu, J., Sun, R., Mumbach, M. R., Carter, A. C., Chen, Y. G., … Chang, H. Y. (2018). Promoter of IncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. CELL , 173 (6), 1398-+.
• Mechanistic insights in X-chromosome inactivation Lu, Z., Carter, A. C., & Chang, H. Y. (2017). Mechanistic insights in X-chromosome inactivation. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES , 372 (1733).
• A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells Van Gool, F., Nguyen, M. L. T., Mumbach, M. R., Satpathy, A. T., Rosenthal, W. L., Giacometti, S., … Bluestone, J. A. (2019). A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. IMMUNITY , 50 (2), 362-+.
• TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment Li, L., Wang, Y., Torkelson, J. L., Shankar, G., Pattison, J. M., Zhen, H. H., … Oro, A. E. (2019). TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. CELL STEM CELL , 24 (2), 271-+.
• Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons Luo, C., Lee, Q. Y., Wapinski, O., Castanon, R., Nery, J. R., Malin, M., … Ecker, J. R. (2019). Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons. ELIFE , 8 .
• The novel lncRNA lnc-NR2F1 is proneurogenic and mutated in human neurodevelopmental disorders Ang, C. E., Ma, Q., Wapinski, O. L., Fan, S. H., Flynn, R. A., Lee, Q. Y., … Chang, H. Y. (2019). The novel lncRNA lnc-NR2F1 is proneurogenic and mutated in human neurodevelopmental disorders. ELIFE , 8 .
• The RNA Base-Pairing Problem and Base-Pairing Solutions Lu, Z., & Chang, H. Y. (2018). The RNA Base-Pairing Problem and Base-Pairing Solutions. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY , 10 (12).
• Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment Pattison, J. M., Melo, S. P., Piekos, S. N., Torkelson, J. L., Bashkirova, E., Mumbach, M. R., … Oro, A. E. (2018). Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. NATURE GENETICS , 50 (12), 1658-+.
• Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity Chen, X., Litzenburger, U. M., Wei, Y., Schep, A. N., LaGory, E. L., Choudhry, H., … Chang, H. Y. (2018). Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. NATURE COMMUNICATIONS , 9 .
• Enhancer Connectome Nominates Target Genes of Inherited Risk Variants from Inflammatory Skin Disorders Jeng, M. Y., Mumbach, M. R., Granja, J. M., Satpathy, A. T., Chang, H. Y., & Chang, A. L. S. (2019). Enhancer Connectome Nominates Target Genes of Inherited Risk Variants from Inflammatory Skin Disorders. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 139 (3), 605–14.
• A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas Arda, H. E., Tsai, J., Rosli, Y. R., Giresi, P., Bottino, R., Greenleaf, W. J., … Kim, S. K. (2018). A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas. CELL SYSTEMS , 7 (3), 310-+.
• Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations Duren, Z., Chen, X., Zamanighomi, M., Zeng, W., Satpathy, A. T., Chang, H. Y., … Wong, W. H. (2018). Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 115 (30), 7723–28.
• An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1 Chen, L., Roake, C. M., Freund, A., Batista, P. J., Tian, S., Yin, Y. A., … Artandi, S. E. (2018). An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. CELL , 174 (1), 218-+.
• Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin Satpathy, A. T., Brown, R. A., Gomulia, E., Briseno, C. G., Mumbach, M. R., Pan, Z., … Kim, J. (2018). Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin. MODERN PATHOLOGY , 31 (9), 1479–86.
• Epigenomics Technologies and Applications Wang, K. C., & Chang, H. Y. (2018). Epigenomics Technologies and Applications. CIRCULATION RESEARCH , 122 (9), 1191–99.
• Unraveling keratinocyte gene regulatory networks with single-cell cripsr screening and epigenomic profiling Ramanathan, M., Rubin, A., Parker, K., Satpathy, A., Greenleaf, W., Chang, H., & Khavari, P. (2019). Unraveling keratinocyte gene regulatory networks with single-cell cripsr screening and epigenomic profiling. JOURNAL OF INVESTIGATIVE DERMATOLOGY . ELSEVIER SCIENCE INC.
• HiChIRP reveals RNA-associated chromosome conformation. Mumbach, M. R., Granja, J. M., Flynn, R. A., Roake, C. M., Satpathy, A. T., Rubin, A. J., … Chang, H. Y. (2019). HiChIRP reveals RNA-associated chromosome conformation. Nature Methods .
• Engineering AP1 to combat CAR T cell exhaustion Lynn, R. C., Weber, E. W., Gennert, D., Sotillo, E., Jones, R., Xu, P., … Mackall, C. L. (2018). Engineering AP1 to combat CAR T cell exhaustion. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Genome regulation by long noncoding RNAs Chang, H. Y. (2018). Genome regulation by long noncoding RNAs. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Atlas of Subcellular RNA Localization Revealed by APEX-Seq. Fazal, F. M., Han, S., Parker, K. R., Kaewsapsak, P., Xu, J., Boettiger, A. N., … Ting, A. Y. (2019). Atlas of Subcellular RNA Localization Revealed by APEX-Seq. Cell .
• Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C. K., Garg, P., … Wu, J. C. (2019). Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature .
• Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions. Ghosh, R. P., Shi, Q., Yang, L., Reddick, M. P., Nikitina, T., Zhurkin, V. B., … Liphardt, J. T. (2019). Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions. Nature Communications , 10 (1), 3221.
• Clonal replacement of tumor-specific T cells following PD-1 blockade. Yost, K. E., Satpathy, A. T., Wells, D. K., Qi, Y., Wang, C., Kageyama, R., … Chang, H. Y. (2019). Clonal replacement of tumor-specific T cells following PD-1 blockade. Nature Medicine .
• Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion. Satpathy, A. T., Granja, J. M., Yost, K. E., Qi, Y., Meschi, F., McDermott, G. P., … Chang, H. Y. (2019). Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion. Nature Biotechnology , 37 (8), 925–36.
• Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Durai, V., Bagadia, P., Granja, J. M., Satpathy, A. T., Kulkarni, D. H., Davidson, J. T., … Murphy, K. M. (2019). Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Nature Immunology .
• An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development. Bagadia, P., Huang, X., Liu, T.-T. T., Durai, V., Grajales-Reyes, G. E., Nitschké, M., … Murphy, K. M. (2019). An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development. Nature Immunology .
• The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation. Bousard, A., Raposo, A. C., Zylicz, J. J., Picard, C., Pires, V. B., Qi, Y., … da Rocha, S. T. (2019). The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation. EMBO Reports , e48019.
• N6-Methyladenosine Modification Controls Circular RNA Immunity. Chen, Y. G., Chen, R., Ahmad, S., Verma, R., Kasturi, S. P., Amaya, L., … Chang, H. Y. (2019). N6-Methyladenosine Modification Controls Circular RNA Immunity. Molecular Cell .
• GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. López-Isac, E., Acosta-Herrera, M., Kerick, M., Assassi, S., Satpathy, A. T., Granja, J., … Martin, J. (2019). GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Nature Communications , 10 (1), 4955.
• Chromatin accessibility landscape in healthy and scleroderma skin nominate dendritic cells in disease pathogenesis Liu, Q., Longmire, M., Qu, K., & Chang, H. Y. (2019). Chromatin accessibility landscape in healthy and scleroderma skin nominate dendritic cells in disease pathogenesis. EUROPEAN JOURNAL OF IMMUNOLOGY . WILEY.
• Intrinsic Chromatin State and Extrinsic Wound-Related Cues Can Coordinate to Activate Fibroblasts for Scarring desJardins-Park, H. E., Moore, A. L., Litzenburger, U., Mascharak, S., Chinta, M., Ransom, R. C., … Longaker, M. T. (2019). Intrinsic Chromatin State and Extrinsic Wound-Related Cues Can Coordinate to Activate Fibroblasts for Scarring. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS . ELSEVIER SCIENCE INC.
• First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma. Stadtmauer, E. A., Cohen, A. D., Weber, K., Lacey, S. F., Gonzalez, V. E., Melenhorst, J. J., … June, C. H. (2019). First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma. Blood , 134 (Supplement_1), 49.
• Circular ecDNA promotes accessible chromatin and high oncogene expression. Wu, S., Turner, K. M., Nguyen, N., Raviram, R., Erb, M., Santini, J., … Mischel, P. S. (2019). Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature .
• Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia. Granja, J. M., Klemm, S., McGinnis, L. M., Kathiria, A. S., Mezger, A., Corces, M. R., … Greenleaf, W. J. (2019). Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia. Nature Biotechnology .
• c-Jun overexpression in CAR T cells induces exhaustion resistance. Lynn, R. C., Weber, E. W., Sotillo, E., Gennert, D., Xu, P., Good, Z., … Mackall, C. L. (2019). c-Jun overexpression in CAR T cells induces exhaustion resistance. Nature .
• Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. Esfahani, M. S., Lee, L. J., Jeon, Y.-J. J., Flynn, R. A., Stehr, H., Hui, A. B., … Diehn, M. (2019). Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. Nature Communications , 10 (1), 5712.
• Tracking the immune response with single-cell genomics. Yost, K. E., Chang, H. Y., & Satpathy, A. T. (2019). Tracking the immune response with single-cell genomics. Vaccine .
• PIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications. Fang, J., Ma, Q., Chu, C., Huang, B., Li, L., Cai, P., … Chang, H. Y. (2019). PIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications. Genome Biology , 20 (1), 292.
• Identifying the chromatin accessibility states of oligodendrocytes during development and in disease with scATAC-seq Meijer, M., Agirre, E., Chen, X., Heskol, A., Gezelius, H., Linnarsson, S., … Castelo-Branco, G. (2019). Identifying the chromatin accessibility states of oligodendrocytes during development and in disease with scATAC-seq. GLIA . WILEY.
• Chromatin accessibility dynamics in a model of human forebrain development. Trevino, A. E., Sinnott-Armstrong, N., Andersen, J., Yoon, S.-J. J., Huber, N., Pritchard, J. K., … Pa?ca, S. P. (2020). Chromatin accessibility dynamics in a model of human forebrain development. Science (New York, N.Y.) , 367 (6476).
• Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. Li, Y., Gruber, J. J., Litzenburger, U. M., Zhou, Y., Miao, Y. R., LaGory, E. L., … Ye, J. (2020). Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. Cell Death & Disease , 11 (2), 102.
• CRISPR-engineered T cells in patients with refractory cancer. Stadtmauer, E. A., Fraietta, J. A., Davis, M. M., Cohen, A. D., Weber, K. L., Lancaster, E., … June, C. H. (2020). CRISPR-engineered T cells in patients with refractory cancer. Science (New York, N.Y.) .
• Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH. Wasson, C. W., Abignano, G., Hermes, H., Malaab, M., Ross, R. L., Jimenez, S. A., … Del Galdo, F. (2020). Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH. Annals of the Rheumatic Diseases .
• Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Horlbeck, M. A., Liu, S. J., Chang, H. Y., Lim, D. A., & Weissman, J. S. (2020). Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Nature Biotechnology .
• CRISPRpic: fast and precise analysis for CRISPR-induced mutations via prefixed index counting. Lee, H. J., Chang, H. Y., Cho, S. W., & Ji, H. P. (2020). CRISPRpic: fast and precise analysis for CRISPR-induced mutations via prefixed index counting. NAR Genomics and Bioinformatics , 2 (2), lqaa012.
• 3D ATAC-PALM: super-resolution imaging of the accessible genome. Xie, L., Dong, P., Chen, X., Hsieh, T.-H. S., Banala, S., De Marzio, M., … Liu, Z. (2020). 3D ATAC-PALM: super-resolution imaging of the accessible genome. Nature Methods .
• RNA-GPS predicts high-resolution RNA subcellular localization and highlights the role of splicing. Wu, K. E., Parker, K. R., Fazal, F. M., Chang, H., & Zou, J. (2020). RNA-GPS predicts high-resolution RNA subcellular localization and highlights the role of splicing. RNA (New York, N.Y.) .
• Single-cell RNA sequencing in cardiovascular development, disease and medicine. Paik, D. T., Cho, S., Tian, L., Chang, H. Y., & Wu, J. C. (2020). Single-cell RNA sequencing in cardiovascular development, disease and medicine. Nature Reviews. Cardiology .
• Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes. Lee, Q. Y., Mall, M., Chanda, S., Zhou, B., Sharma, K. S., Schaukowitch, K., … Wernig, M. (2020). Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes. Nature Cell Biology .
• Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation. Carter, A. C., Xu, J., Nakamoto, M. Y., Wei, Y., Zarnegar, B. J., Shi, Q., … Chang, H. Y. (2020). Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation. ELife , 9 .
• Functional significance of U2AF1 S34F mutations in lung adenocarcinomas Shahrokh Esfahani, M. (2019). Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. Nature Communications , 10 .
• A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T-reg cells Nasrallah, R., Imianowski, C. J., Bossini-Castillo, L., Grant, F. M., Dogan, M., Placek, L., … Roychoudhuri, R. (2020). A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T-reg cells. NATURE .
• Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation. Fazal, F. M., & Chang, H. Y. (2020). Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation. Cold Spring Harbor Symposia on Quantitative Biology .
• CD19-Positive Brain Pericytes as Targets of Immunotherapy-Associated Neurotoxicity Migliorini, D., Parker, K., Perkey, E., Bagga, P., Liu, F., Maillard, I., … Satpathy, A. (2020). CD19-Positive Brain Pericytes as Targets of Immunotherapy-Associated Neurotoxicity. MOLECULAR THERAPY . CELL PRESS.
• Genome regulation by long noncoding RNA genes Chang, H. Y. (2020). Genome regulation by long noncoding RNA genes. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells. Nasrallah, R., Imianowski, C. J., Bossini-Castillo, L., Grant, F. M., Dogan, M., Placek, L., … Roychoudhuri, R. (2020). A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells. Nature .
• Diverse lncRNA mechanisms in brain development and disease. Ang, C. E., Trevino, A. E., & Chang, H. Y. (2020). Diverse lncRNA mechanisms in brain development and disease. Current Opinion in Genetics & Development , 65 , 42–46.
• Long Noncoding RNAs: Molecular Modalities to Organismal Functions. Rinn, J. L., & Chang, H. Y. (2020). Long Noncoding RNAs: Molecular Modalities to Organismal Functions. Annual Review of Biochemistry , 89 , 283–308.
• Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Vardhana, S. A., Hwee, M. A., Berisa, M., Wells, D. K., Yost, K. E., King, B., … Thompson, C. B. (2020). Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Nature Immunology .
• RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus. Wu, K. E., Fazal, F. M., Parker, K. R., Zou, J., & Chang, H. Y. (2020). RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus. Cell Systems .
• Functional annotation of human long noncoding RNAs via molecular phenotyping. Ramilowski, J. A., Yip, C. W., Agrawal, S., Chang, J.-C. C., Ciani, Y., Kulakovskiy, I. V., … Carninci, P. (2020). Functional annotation of human long noncoding RNAs via molecular phenotyping. Genome Research .
• Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Wilson, K. D., Ameen, M., Guo, H., Abilez, O. J., Tian, L., Mumbach, M. R., … Wu, J. C. (2020). Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Developmental Cell .
• Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2. Nielsen, S. C., Yang, F., Jackson, K. J., Hoh, R. A., Röltgen, K., Stevens, B., … Boyd, S. D. (2020). Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2. BioRxiv : the Preprint Server for Biology .
• Functional annotation of human long noncoding RNAs via molecular phenotyping Ramilowski, J. A., Yip, C. W., Agrawal, S., Chang, J.-C., Ciani, Y., Kulakovskiy, I. V., … Carninci, P. (2020). Functional annotation of human long noncoding RNAs via molecular phenotyping. GENOME RESEARCH , 30 (7), 1060–72.
• Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers. Kim, H., Nguyen, N.-P., Turner, K., Wu, S., Gujar, A. D., Luebeck, J., … Verhaak, R. G. (2020). Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers. Nature Genetics .
• The road ahead in genetics and genomics. McGuire, A. L., Gabriel, S., Tishkoff, S. A., Wonkam, A., Chakravarti, A., Furlong, E. E., … Kim, J.-S. (2020). The road ahead in genetics and genomics. Nature Reviews. Genetics .
• Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2. Nielsen, S. C., Yang, F., Jackson, K. J., Hoh, R. A., Röltgen, K., Jean, G. H., … Boyd, S. D. (2020). Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2. Cell Host & Microbe .
• Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies. Parker, K. R., Migliorini, D., Perkey, E., Yost, K. E., Bhaduri, A., Bagga, P., … Satpathy, A. T. (2020). Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies. Cell .
• Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity. Leylek, R., Alcántara-Hernández, M., Granja, J. M., Chavez, M., Perez, K., Diaz, O. R., … Idoyaga, J. (2020). Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity. Cell Reports , 32 (12), 108180.
• Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases. Corces, M. R., Shcherbina, A., Kundu, S., Gloudemans, M. J., Fresard, L., Granja, J. M., … Montine, T. J. (2020). Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases. Nature Genetics .
• Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis. Leavitt, T., Hu, M. S., Borrelli, M. R., Januszyk, M., Garcia, J. T., Ransom, R. C., … Longaker, M. T. (2020). Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis. Cell Reports , 33 (6), 108356.
• Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis. Liu, Q., Zaba, L., Satpathy, A. T., Longmire, M., Zhang, W., Li, K., … Chang, H. Y. (2020). Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis. Nature Communications , 11 (1), 5843.
• Footprinting SHAPE-eCLIP Reveals Transcriptome-wide Hydrogen Bonds at RNA-Protein Interfaces. Corley, M., Flynn, R. A., Lee, B., Blue, S. M., Chang, H. Y., & Yeo, G. W. (2020). Footprinting SHAPE-eCLIP Reveals Transcriptome-wide Hydrogen Bonds at RNA-Protein Interfaces. Molecular Cell .
• Structural modularity of the XIST ribonucleoprotein complex. Lu, Z., Guo, J. K., Wei, Y., Dou, D. R., Zarnegar, B., Ma, Q., … Chang, H. Y. (2020). Structural modularity of the XIST ribonucleoprotein complex. Nature Communications , 11 (1), 6163.
• Distinct Immune Regulatory Potential of Invariant Natural Killer T (iNKT) Cell Subsets: iNKT2 and iNKT17, but Not iNKT1, Protect from Graft-Versus-Host-Disease Simonetta, F., Maas-Bauer, K., Hirai, T., Wenokur, A., Fazal, F. M., Kambham, N., … Negrin, R. S. (2019). Distinct Immune Regulatory Potential of Invariant Natural Killer T (iNKT) Cell Subsets: iNKT2 and iNKT17, but Not iNKT1, Protect from Graft-Versus-Host-Disease. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION . ELSEVIER SCIENCE INC.
• Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set. Kebschull, J. M., Richman, E. B., Ringach, N., Friedmann, D., Albarran, E., Kolluru, S. S., … Luo, L. (2020). Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set. Science (New York, N.Y.) , 370 (6523).
• Personal regulome navigation Chang, H. Y. (2018). Personal regulome navigation. MOLECULAR CANCER THERAPEUTICS . AMER ASSOC CANCER RESEARCH.
• ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis. Granja, J. M., Corces, M. R., Pierce, S. E., Bagdatli, S. T., Choudhry, H., Chang, H. Y., & Greenleaf, W. J. (2021). ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis. Nature Genetics .
• Deciphering Warburg effect: hypoxia inhibits tumor cell differentiation through reducing acetyl-CoA generation and chromatin accessibility Ye, J., Li, Y., Gruber, J. J., Litzenburger, U. M., Zhou, Y., Miao, Y. R., … Giaccia, A. J. (2020). Deciphering Warburg effect: hypoxia inhibits tumor cell differentiation through reducing acetyl-CoA generation and chromatin accessibility. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Personal regulome navigation of cancer Chang, H. Y. (2020). Personal regulome navigation of cancer. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Flynn, R. A., Belk, J. A., Qi, Y., Yasumoto, Y., Wei, J., Alfajaro, M. M., … Satpathy, A. T. (2021). Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell .
• B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells. Yu, B., Qi, Y., Li, R., Shi, Q., Satpathy, A. T., & Chang, H. Y. (2021). B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells. Cell .
• Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Weber, E. W., Parker, K. R., Sotillo, E., Lynn, R. C., Anbunathan, H., Lattin, J., … Mackall, C. L. (2021). Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Science (New York, N.Y.) , 372 (6537).
• BABEL enables cross-modality translation between multiomic profiles at single-cell resolution. Wu, K. E., Yost, K. E., Chang, H. Y., & Zou, J. (2021). BABEL enables cross-modality translation between multiomic profiles at single-cell resolution. Proceedings of the National Academy of Sciences of the United States of America , 118 (15).
• Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Nunez, J. K., Chen, J., Pommier, G. C., Cogan, J. Z., Replogle, J. M., Adriaens, C., … Weissman, J. S. (2021). Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell .
• Recruiting T cells in cancer immunotherapy. Yost, K. E., Chang, H. Y., & Satpathy, A. T. (2021). Recruiting T cells in cancer immunotherapy. Science (New York, N.Y.) , 372 (6538), 130–31.
• Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE Chen, L., Chang, H. Y., & Artandi, S. E. (2021). Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE. STAR Protocols , 2 (2).
• Invariant Natural Killer T Cell Subsets Have Diverse Graft-Versus-Host-Disease-Preventing and Anti-Tumor Effects. Maas-Bauer, K., Lohmeyer, J. K., Hirai, T., Lopes Ramos, T., Fazal, F. M., Litzenburger, U. M., … Negrin, R. S. (2021). Invariant Natural Killer T Cell Subsets Have Diverse Graft-Versus-Host-Disease-Preventing and Anti-Tumor Effects. Blood .
• Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detection. Ram-Mohan, N., Thair, S. A., Litzenburger, U. M., Cogill, S., Andini, N., Yang, X., … Yang, S. (2021). Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detection. Life Science Alliance , 4 (8).
• Personal regulome navigation of cancer. Chang, H. Y. (2021). Personal regulome navigation of cancer. Nature Reviews. Cancer .
• Dynamic chromatin regulatory landscape of human CAR T cell exhaustion. Gennert, D. G., Lynn, R. C., Granja, J. M., Weber, E. W., Mumbach, M. R., Zhao, Y., … Chang, H. Y. (2021). Dynamic chromatin regulatory landscape of human CAR T cell exhaustion. Proceedings of the National Academy of Sciences of the United States of America , 118 (30).
• LKB1 inactivation modulates chromatin accessibility to drive metastatic progression. Pierce, S. E., Granja, J. M., Corces, M. R., Brady, J. J., Tsai, M. K., Pierce, A. B., … Winslow, M. M. (2021). LKB1 inactivation modulates chromatin accessibility to drive metastatic progression. Nature Cell Biology .
• Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution. Trevino, A. E., Müller, F., Andersen, J., Sundaram, L., Kathiria, A., Shcherbina, A., … Greenleaf, W. J. (2021). Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution. Cell .
• Structured elements drive extensive circular RNA translation. Chen, C.-K. K., Cheng, R., Demeter, J., Chen, J., Weingarten-Gabbay, S., Jiang, L., … Chang, H. Y. (2021). Structured elements drive extensive circular RNA translation. Molecular Cell .
• fSHAPE, fSHAPE-eCLIP, and SHAPE-eCLIP probe transcript regions that interact with specific proteins. Corley, M., Flynn, R. A., Blue, S. M., Yee, B. A., Chang, H. Y., & Yeo, G. W. (2021). fSHAPE, fSHAPE-eCLIP, and SHAPE-eCLIP probe transcript regions that interact with specific proteins. STAR Protocols , 2 (3), 100762.
• Genome-Wide Probing of RNA Structures In Vitro Using Nucleases and Deep Sequencing Wan, Y., Qu, K., Ouyang, Z., & Chang, H. Y. (2016). Genome-Wide Probing of RNA Structures In Vitro Using Nucleases and Deep Sequencing. YEAST FUNCTIONAL GENOMICS , 1361 , 141–160.
• Locus specific epigenetic modalities of random allelic expression imbalance. Marion-Poll, L., Forêt, B., Zielinski, D., Massip, F., Attia, M., Carter, A. C., … Heard, E. (2021). Locus specific epigenetic modalities of random allelic expression imbalance. Nature Communications , 12 (1), 5330.
• JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models. Griffin, M. F., Borrelli, M. R., Garcia, J. T., Januszyk, M., King, M., Lerbs, T., … Longaker, M. T. (2021). JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models. Science Translational Medicine , 13 (609), eabb3312.
• Chromatin accessibility associates with protein-RNA correlation in human cancer. Sanghi, A., Gruber, J. J., Metwally, A., Jiang, L., Reynolds, W., Sunwoo, J., … Snyder, M. P. (2021). Chromatin accessibility associates with protein-RNA correlation in human cancer. Nature Communications , 12 (1), 5732.
• Integrated spatial multiomics reveals fibroblast fate during tissue repair. Foster, D. S., Januszyk, M., Yost, K. E., Chinta, M. S., Gulati, G. S., Nguyen, A. T., … Longaker, M. T. (2021). Integrated spatial multiomics reveals fibroblast fate during tissue repair. Proceedings of the National Academy of Sciences of the United States of America , 118 (41).
• The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation. Kim, D. S., Risca, V. I., Reynolds, D. L., Chappell, J., Rubin, A. J., Jung, N., … Khavari, P. A. (2021). The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation. Nature Genetics .
• Extrachromosomal DNA: An Emerging Hallmark in Human Cancer. Wu, S., Bafna, V., Chang, H. Y., & Mischel, P. S. (2021). Extrachromosomal DNA: An Emerging Hallmark in Human Cancer. Annual Review of Pathology .
• NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity. Richards, R. M., Zhao, F., Freitas, K. A., Parker, K. R., Xu, P., Fan, A., … Mackall, C. L. (2021). NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity. Blood Cancer Discovery , 2 (6), 648–665.
• Noncoding RNAs: biology and applications-a Keystone Symposia report. Cable, J., Heard, E., Hirose, T., Prasanth, K. V., Chen, L.-L. L., Henninger, J. E., … Liu, X. (2021). Noncoding RNAs: biology and applications-a Keystone Symposia report. Annals of the New York Academy of Sciences .
• Cancer-Associated Fibroblasts Share Highly Conserved Phenotypes and Functions Across Tumor Types and Species Foster, D. S., Januszyk, M., Yost, K. E., Chinta, M., Titan, A. L., Wapnir, I. L., … Longaker, M. T. (2021). Cancer-Associated Fibroblasts Share Highly Conserved Phenotypes and Functions Across Tumor Types and Species. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS . ELSEVIER SCIENCE INC.
• ecDNA hubs drive cooperative intermolecular oncogene expression. Hung, K. L., Yost, K. E., Xie, L., Shi, Q., Helmsauer, K., Luebeck, J., … Chang, H. Y. (2021). ecDNA hubs drive cooperative intermolecular oncogene expression. Nature .
• PEPATAC: an optimized pipeline for ATAC-seq data analysis with serial alignments. Smith, J. P., Corces, M. R., Xu, J., Reuter, V. P., Chang, H. Y., & Sheffield, N. C. (2021). PEPATAC: an optimized pipeline for ATAC-seq data analysis with serial alignments. NAR Genomics and Bioinformatics , 3 (4), lqab101.
• Toward a better understanding of T cells in cancer Oh, D. Y., Fong, L., Newell, E. W., Turk, M. J., Chi, H., Chang, H. Y., … Lantz, O. (2021). Toward a better understanding of T cells in cancer. CANCER CELL , 39 (12), 1549–1552.
• GPC2-CAR Tcells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity. Heitzeneder, S., Bosse, K. R., Zhu, Z., Zhelev, D., Majzner, R. G., Radosevich, M. T., … Mackall, C. L. (1800). GPC2-CAR Tcells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity. Cancer Cell .
• Identification of Protein-RNA Interactions in Mouse Testis Tissue Using fRIP Bailey, A., Batista, P., Chang, H., & Fuller, M. (2022). Identification of Protein-RNA Interactions in Mouse Testis Tissue Using fRIP. BIO-PROTOCOL , 12 (01).
• Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility. Meijer, M., Agirre, E., Kabbe, M., van Tuijn, C. A., Heskol, A., Zheng, C., … Castelo-Branco, G. (1800). Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility. Neuron .
• GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity Heitzeneder, S., Bosse, K. R., Zhu, Z., Zhelev, D., Majzner, R. G., Radosevich, M. T., … Mackall, C. L. (2022). GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity. CANCER CELL , 40 (1), 53-+.
• Identification of Protein-RNA Interactions in Mouse Testis Tissue Using fRIP. Bailey, A. S., Batista, P. J., Chang, H. Y., & Fuller, M. T. (2022). Identification of Protein-RNA Interactions in Mouse Testis Tissue Using fRIP. Bio-Protocol , 12 (1), e4286.
• Circular RNA migration in agarose gel electrophoresis. Abe, B. T., Wesselhoeft, R. A., Chen, R., Anderson, D. G., & Chang, H. Y. (2022). Circular RNA migration in agarose gel electrophoresis. Molecular Cell .
• BRD2 compartmentalizes the accessible genome. Xie, L., Dong, P., Qi, Y., Hsieh, T.-H. S., English, B. P., Jung, S. K., … Liu, Z. (2022). BRD2 compartmentalizes the accessible genome. Nature Genetics .
• Oncogene Convergence in Extrachromosomal DNA Hubs. Weiser, N. E., Hung, K. L., & Chang, H. Y. (2022). Oncogene Convergence in Extrachromosomal DNA Hubs. Cancer Discovery , OF1–OF4.
• A genetic bottleneck of mitochondrial DNA during human lymphocyte development. Tang, Z., Lu, Z., Chen, B., Zhang, W., Chang, H. Y., Hu, Z., & Xu, J. (2022). A genetic bottleneck of mitochondrial DNA during human lymphocyte development. Molecular Biology and Evolution .
• Enhanced safety and efficacy of protease-regulated CAR-T cell receptors. Labanieh, L., Majzner, R. G., Klysz, D., Sotillo, E., Fisher, C. J., Vilches-Moure, J. G., … Mackall, C. L. (2022). Enhanced safety and efficacy of protease-regulated CAR-T cell receptors. Cell .
• The Mettl3 epitranscriptomic writer amplifies p53 stress responses. Raj, N., Wang, M., Seoane, J. A., Zhao, R. L., Kaiser, A. M., Moonie, N. A., … Attardi, L. D. (2022). The Mettl3 epitranscriptomic writer amplifies p53 stress responses. Molecular Cell .
• Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Kraft, K., Yost, K. E., Murphy, S. E., Magg, A., Long, Y., Corces, M. R., … Chang, H. Y. (2022). Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Proceedings of the National Academy of Sciences of the United States of America , 119 (22), e2201883119.
• RNA-binding proteins direct myogenic cell fate decisions. Wheeler, J. R., Whitney, O. N., Vogler, T. O., Nguyen, E. D., Pawlikowski, B., Lester, E., … Olwin, B. B. (2022). RNA-binding proteins direct myogenic cell fate decisions. ELife , 11 .
• Engineering circular RNA for enhanced protein production. Chen, R., Wang, S. K., Belk, J. A., Amaya, L., Li, Z., Cardenas, A., … Chang, H. Y. (2022). Engineering circular RNA for enhanced protein production. Nature Biotechnology .
• Gene regulation on extrachromosomal DNA. Hung, K. L., Mischel, P. S., & Chang, H. Y. (2022). Gene regulation on extrachromosomal DNA. Nature Structural & Molecular Biology .
• KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress. Moonen, J.-R. R., Chappell, J., Shi, M., Shinohara, T., Li, D., Mumbach, M. R., … Rabinovitch, M. (2022). KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress. Nature Communications , 13 (1), 4941.
• The evolutionary dynamics of extrachromosomal DNA in human cancers. Lange, J. T., Rose, J. C., Chen, C. Y., Pichugin, Y., Xie, L., Tang, J., … Mischel, P. S. (2022). The evolutionary dynamics of extrachromosomal DNA in human cancers. Nature Genetics .
• Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. Hung, K. L., Luebeck, J., Dehkordi, S. R., Colon, C. I., Li, R., Wong, I. T.-L., … Chang, H. Y. (2022). Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. Nature Genetics .
• Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin. Foster, D. S., Januszyk, M., Delitto, D., Yost, K. E., Griffin, M., Guo, J., … Longaker, M. T. (2022). Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin. Cancer Cell .
• Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases. Wang, S. K., Nair, S., Li, R., Kraft, K., Pampari, A., Patel, A., … Chang, H. Y. (2022). Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases. Cell Genomics , 2 (8).
• Divergent clonal differentiation trajectories of T cell exhaustion. Daniel, B., Yost, K. E., Hsiung, S., Sandor, K., Xia, Y., Qi, Y., … Satpathy, A. T. (2022). Divergent clonal differentiation trajectories of T cell exhaustion. Nature Immunology .
• Enhanced T cell effector activity by targeting the Mediator kinase module. Freitas, K. A., Belk, J. A., Sotillo, E., Quinn, P. J., Ramello, M. C., Malipatlolla, M., … Mackall, C. L. (2022). Enhanced T cell effector activity by targeting the Mediator kinase module. Science (New York, N.Y.) , 378 (6620), eabn5647.
• Profiling oncogenic extra-chromosomal DNA in cancer Hung, K. L., & Chang, H. Y. (2022). Profiling oncogenic extra-chromosomal DNA in cancer. NATURE GENETICS , 1591–1592.
• Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state. Daniel, B., Belk, J. A., Meier, S. L., Chen, A. Y., Sandor, K., Czimmerer, Z., … Satpathy, A. T. (2022). Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state. Molecular Cell .
• Engineered cell entry links receptor biology with single-cell genomics. Yu, B., Shi, Q., Belk, J. A., Yost, K. E., Parker, K. R., Li, R., … Chang, H. Y. (2022). Engineered cell entry links receptor biology with single-cell genomics. Cell .
• The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1. Haddad Derafshi, B., Danko, T., Chanda, S., Batista, P. J., Litzenburger, U., Lee, Q. Y., … Wernig, M. (2022). The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1. Scientific Reports , 12 (1), 22425.
• Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis. Ma, Q., Yang, L., Tolentino, K., Wang, G., Zhao, Y., Litzenburger, U. M., … Chang, H. Y. (2022). Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis. ELife , 11 .
• Long non-coding RNAs: definitions, functions, challenges and recommendations. Mattick, J. S., Amaral, P. P., Carninci, P., Carpenter, S., Chang, H. Y., Chen, L.-L., … Wu, M. (2023). Long non-coding RNAs: definitions, functions, challenges and recommendations. Nature Reviews. Molecular Cell Biology .
• A guide to naming eukaryotic circular RNAs. Chen, L.-L., Bindereif, A., Bozzoni, I., Chang, H. Y., Matera, A. G., Gorospe, M., … Zhao, F. (2023). A guide to naming eukaryotic circular RNAs. Nature Cell Biology .
• Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing. Chang, H. Y., & Qi, L. S. (2023). Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing. Molecular Cell , 83 (3), 442–451.
• Reading and writing extrachromosomal DNA. Chang, H. Y. (2022). Reading and writing extrachromosomal DNA. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark Corley, M., Solem, A., Qu, K., Chang, H. Y., & Laederach, A. (2015). Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark. NUCLEIC ACIDS RESEARCH , 43 (3), 1859–1868.
• Enhanced effector activity of mediator CDK8 kinase module deficient CAR-T Cells Freitas, K. A., Belk, J. A., Sotillo, E., Daniel, B., Sandor, K., Klysz, D., … Mackall, C. (2022). Enhanced effector activity of mediator CDK8 kinase module deficient CAR-T Cells. CANCER RESEARCH . AMER ASSOC CANCER RESEARCH.
• Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus. Luebeck, J., Ng, A. W., Galipeau, P. C., Li, X., Sanchez, C. A., Katz-Summercorn, A. C., … Mischel, P. S. (2023). Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus. Nature .
• The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner. Gonzalez-Sandoval, A., Pekrun, K., Tsuji, S., Zhang, F., Hung, K. L., Chang, H. Y., & Kay, M. A. (2023). The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner. Nature Communications , 14 (1), 2448.
• Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Chamorro González, R., Conrad, T., Stöber, M. C., Xu, R., Giurgiu, M., Rodriguez-Fos, E., … Henssen, A. G. (2023). Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature Genetics .
• Circular RNA vaccine induces potent T cell responses. Amaya, L., Grigoryan, L., Li, Z., Lee, A., Wender, P. A., Pulendran, B., & Chang, H. Y. (2023). Circular RNA vaccine induces potent T cell responses. Proceedings of the National Academy of Sciences of the United States of America , 120 (20), e2302191120.
• Machine learning modeling of RNA structures: methods, challenges and future perspectives. Wu, K. E., Zou, J. Y., & Chang, H. (2023). Machine learning modeling of RNA structures: methods, challenges and future perspectives. Briefings in Bioinformatics .
• Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature. Berson, E., Sreenivas, A., Phongpreecha, T., Perna, A., Grandi, F. C., Xue, L., … Montine, T. J. (2023). Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature. Nature Communications , 14 (1), 4947.
• Mechanoresponsive Pancreatic Ductal Adenocarcinoma Cancer Associated Fibroblasts Shows an FAK-Dependent Subtype Divergent from Canonical Fibrotic TGFB-Pathway Dependence Foster, D., Delitto, D., Januszyk, M., Yost, K., Griffin, M., Guo, J., … Longaker, M. (2023). Mechanoresponsive Pancreatic Ductal Adenocarcinoma Cancer Associated Fibroblasts Shows an FAK-Dependent Subtype Divergent from Canonical Fibrotic TGFB-Pathway Dependence. ANNALS OF SURGICAL ONCOLOGY . SPRINGER.
• Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. Tsuchida, C. A., Brandes, N., Bueno, R., Trinidad, M., Mazumder, T., Yu, B., … Doudna, J. A. (2023). Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. BioRxiv : the Preprint Server for Biology .
• Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors. Lin, M. S., Jo, S.-Y. Y., Luebeck, J., Chang, H. Y., Wu, S., Mischel, P. S., & Bafna, V. (2023). Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors. BioRxiv : the Preprint Server for Biology .
• Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer's disease. Yu, M., Nie, Y., Yang, J., Yang, S., Li, R., Rao, V., … Chang, J. (2023). Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer's disease. Cell Reports , 42 (11), 113392.
• Charge-altering releasable transporters enhance mRNA delivery in vitro and exhibit in vivo tropism. Li, Z., Amaya, L., Pi, R., Wang, S. K., Ranjan, A., Waymouth, R. M., … Wender, P. A. (2023). Charge-altering releasable transporters enhance mRNA delivery in vitro and exhibit in vivo tropism. Nature Communications , 14 (1), 6983.
• Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. Chapman, O. S., Luebeck, J., Sridhar, S., Wong, I. T.-L., Dixit, D., Wang, S., … Chavez, L. (2023). Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. Nature Genetics .
• Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change. Dehkordi, S. R., Wong, I. T.-L., Ni, J., Luebeck, J., Zhu, K., Prasad, G., … Bafna, V. (2023). Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change. BioRxiv : the Preprint Server for Biology .
• Chromatin activity identifies differential gene regulation across human ancestries. Pettie, K. P., Mumbach, M., Lea, A. J., Ayroles, J., Chang, H. Y., Kasowski, M., & Fraser, H. B. (2024). Chromatin activity identifies differential gene regulation across human ancestries. Genome Biology , 25 (1), 21.
• Xist ribonucleoproteins promote female sex-biased autoimmunity. Dou, D. R., Zhao, Y., Belk, J. A., Zhao, Y., Casey, K. M., Chen, D. C., … Chang, H. Y. (2024). Xist ribonucleoproteins promote female sex-biased autoimmunity. Cell , 187 (3), 733–749.e16.
• Extrachromosomal DNA in cancer. Yan, X., Mischel, P., & Chang, H. (2024). Extrachromosomal DNA in cancer. Nature Reviews. Cancer .
• Approaches to probe and perturb long noncoding RNA functions in diseases. Wang, G., Lee-Yow, Y., & Chang, H. Y. (2024). Approaches to probe and perturb long noncoding RNA functions in diseases. Current Opinion in Genetics & Development , 85 , 102158.
• CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing. Zhu, K., Jones, M. G., Luebeck, J., Bu, X., Yi, H., Hung, K. L., … Bafna, V. (2024). CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing. BioRxiv : the Preprint Server for Biology .
• Regulation of immune signal integration and memory by inflammation-induced chromosome conformation. Daniel, B., Chen, A. Y., Sandor, K., Zhang, W., Miao, Z., Lareau, C. A., … Satpathy, A. T. (2024). Regulation of immune signal integration and memory by inflammation-induced chromosome conformation. BioRxiv : the Preprint Server for Biology .
• Escape from X inactivation is directly modulated by levels of Xist non-coding RNA. Hauth, A., Panten, J., Kneuss, E., Picard, C., Servant, N., Rall, I., … Heard, E. (2024). Escape from X inactivation is directly modulated by levels of Xist non-coding RNA. BioRxiv : the Preprint Server for Biology .
• Annotation of nuclear lncRNAs based on chromatin interactions. Agrawal, S., Buyan, A., Severin, J., Koido, M., Alam, T., Abugessaisa, I., … de Hoon, M. J. (2024). Annotation of nuclear lncRNAs based on chromatin interactions. PloS One , 19 (5), e0295971.
• Organ- and Cell-Selective Delivery of mRNA In Vivo Using Guanidinylated Serinol Charge-Altering Releasable Transporters. Li, Z., Amaya, L., Ee, A., Wang, S. K., Ranjan, A., Waymouth, R. M., … Wender, P. A. (2024). Organ- and Cell-Selective Delivery of mRNA In Vivo Using Guanidinylated Serinol Charge-Altering Releasable Transporters. Journal of the American Chemical Society .
• Bidirectional epigenetic editing reveals hierarchies in gene regulation. Pacalin, N. M., Steinhart, Z., Shi, Q., Belk, J. A., Dorovskyi, D., Kraft, K., … Chang, H. Y. (2024). Bidirectional epigenetic editing reveals hierarchies in gene regulation. Nature Biotechnology .
• Pathways for macrophage uptake of cell-free circular RNAs. Amaya, L., Abe, B., Liu, J., Zhao, F., Zhang, W. L., Chen, R., … Chang, H. Y. (2024). Pathways for macrophage uptake of cell-free circular RNAs. Molecular Cell .
• The CD8+Tcell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects. Van Der Byl, W., Nussing, S., Peters, T. J., Ahn, A., Li, H., Ledergor, G., … Parish, I. A. (2024). The CD8+Tcell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects. Immunity .
• hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing. Zheng, R., Dunlap, M., Bobkov, G. O., Gonzalez-Figueroa, C., Patel, K. J., Lyu, J., … Cheng, C. (2024). hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing. Molecular Cell .
• Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors. Lin, M. S., Jo, S.-Y. Y., Luebeck, J., Chang, H. Y., Wu, S., Mischel, P. S., & Bafna, V. (2024). Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors. ELife , 12 .
• TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-binding analyses Wu, K., Yost, K. E., Daniel, B., Belk, J. A., Xia, Y., Egawa, T., … Zou, J. (2023). TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-binding analyses. MACHINE LEARNING IN COMPUTATIONAL BIOLOGY, VOL 240 . JMLR-JOURNAL MACHINE LEARNING RESEARCH.
• CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing. Zhu, K., Jones, M. G., Luebeck, J., Bu, X., Yi, H., Huang, K. L., … Bafna, V. (2024). CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing. Genome Research .
• Clonal inactivation of TERT impairs stem cell competition. Hasegawa, K., Zhao, Y., Garbuzov, A., Corces, M. R., Neuhöfer, P., Gillespie, V. M., … Artandi, S. E. (2024). Clonal inactivation of TERT impairs stem cell competition. Nature .
• A human autoimmune organoid model reveals IL-7 function in coeliac disease. Santos, A. J., van Unen, V., Lin, Z., Chirieleison, S. M., Ha, N., Batish, A., … Kuo, C. J. (2024). A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature .
• Cohesin prevents cross-domain gene coactivation. Dong, P., Zhang, S., Gandin, V., Xie, L., Wang, L., Lemire, A. L., … Liu, Z. J. (2024). Cohesin prevents cross-domain gene coactivation. Nature Genetics .
• Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair. Rose, J. C., Belk, J. A., Wong, I. T.-L., Luebeck, J., Horn, H. T., Daniel, B., … Chang, H. Y. (2024). Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair. Cancer Discovery .
• Extrachromosomal DNA: Biogenesis and Functions in Cancer Curtis, E. J., Rose, J. C., Mischel, P. S., & Chang, H. Y. (2024). Extrachromosomal DNA: Biogenesis and Functions in Cancer. ANNUAL REVIEW OF CANCER BIOLOGY , 8 , 135–153.
• Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers. Sundaram, L., Kumar, A., Zatzman, M., Salcedo, A., Ravindra, N., Shams, S., … Shen, H. (2024). Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers. Science (New York, N.Y.) , 385 (6713), eadk9217.

Specializing In

• Cutaneous Lymphoma
• Skin Cancer

Practice Locations

Skin cancer program in palo alto palo alto, ca.

Skin Cancer Program in Palo Alto

900 Blake Wilbur Drive, 3rd Floor

Palo Alto , CA 94304

(650) 498-6000

General Dermatology Clinic in Redwood City Redwood City, CA

General Dermatology Clinic in Redwood City

450 Broadway Street, Pavilion B, 4th Floor

Redwood City , CA 94063

(650) 723-6316

Important Information about Our Organizations and Physician Affiliation

Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.

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Ahmed Hawash, MD, PhD

Dr. Hawash is a board-certified dermatologist and Mohs surgeon at Schweiger Dermatology Group.

He provides compassionate and skilled care to his patients. A native New Yorker, Dr. Hawash received his undergraduate degree in biology from the New York Institute of Technology, graduating summa cum laude. He then received his doctoral degree in neuroscience from Wright State University, producing several ground-breaking findings and publications in the field of electrophysiology. He earned his Doctor of Medicine from the Boonshoft School of Medicine at Wright State University and was inducted into the Academy of Medicine while there. 

• Altamont, NY
• Oneonta, NY

Specialties

• Medical Dermatology
• Cosmetic Dermatology

About Ahmed Hawash, MD, PhD

Following completion of his internship at Kettering Medical Center, Dr. Hawash completed his dermatology residency at the University of Miami in Florida, where he served as chief resident of cosmetics. During his residency, he had the opportunity to train under world-renowned academy and thought leaders in dermatology and received extensive training in Mohs surgery, cutaneous oncology, cosmetics, wound healing, itch and complex medical dermatology. 

He serves on local and national committees including the Association of American Medical Colleges, Resident Advisory Committee of the Florida Academy of Dermatology, and State Policy Committee of the American Academy of Dermatology.

Dr. Hawash was born and raised in Brooklyn, NY. After 15 years of undergraduate and graduate education and medical training, he decided to move back to New York to serve patients. Having spent innumerable weekends in the Catskills, he looks forward to spending time with family and enjoying the natural beauty and scenery that Upstate New York has to offer. 

Education & Training

• BS in biology, New York Institute of Technology, summa cum laude
• PhD in neuroscience, Wright State University
• MD, Boonshoft School of Medicine at Wright State University
• Internship, Kettering Medical Center
• Dermatology residency, University of Miami, chief resident of cosmetics

Professional Memberships & Associations

• Association of American Medical Colleges
• Resident Advisory Committee of the Florida Academy of Dermatology
• State Policy Committee of the American Academy of Dermatology

Honors & Awards

• Inducted into Academy of Medicine 

Book an Appointment with Ahmed Hawash, MD, PhD

Location_on altamont, location_on oneonta, location_on 2508 western avenue 2500 western avenue, altamont, ny 12009.

location_on 2508 Western Avenue, 2500 Western Avenue, Altamont, NY 12009

Location_on 6 country club road 2500 western avenue, oneonta, ny 13820.

location_on 6 Country Club Road, 2500 Western Avenue, Oneonta, NY 13820

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location_on -->2508 Western Avenue, 2500 Western Avenue, Altamont, NY 12009

Location_on -->6 country club road, 2500 western avenue, oneonta, ny 13820, see what our patients are saying.

“Very happy with response time, appt time and overall staff is super friendly and caring. I trust them!!!”

“Friendly, helpful staff, clean facility, well organized, very professional.”

“Clean office, friendly staff, and no wait time at all. Top notch experience!”

“Very helpful doctor and friendly staff. Efficient and professional. Highly recommend.”

“They were very professional but treated you like family with open arms. Thank you everyone😊”

“Wonderful staff and providers! I highly recommend their services! Providers are wonderful with kids too.”

About Schweiger Dermatology Group

Schweiger Dermatology Group was founded to help make excellent dermatology care accessible throughout the Northeast. In 2010, Dr. Eric Schweiger started the practice with a single location in Midtown Manhattan. When he saw the need for high-quality dermatology care that did not require weeks or months of waiting to see a qualified provider, his vision of a multi-location practice was born.

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Keith Choate, MD, PhD

Keith Choate, MD, PhD, is a professor of dermatology, genetics and pathology at Yale School of Medicine and a medical dermatologist who treats patients with a variety of skin conditions, including skin cancer, severe acne, psoriasis, and other conditions upon referral by a dermatologist. His expertise in genetic skin disorders leads to referrals from across the country and around the world. Regarding the complex cases he sees, Dr. Choate says, “There's nothing better than solving a medical mystery, and it’s enormously gratifying to see patients get better.”

He reports that some patients have seen many other doctors before coming to Yale Medicine Dermatology, and that they are surprised to discover how things are done differently at Yale Medicine. As a physician-scientist, Dr. Choate and others in the department bring insights from scientific investigation and clinical trials to patient care. “At the end of the day, there's always an answer to complex skin problems if we are willing to work together toward finding a solution,” says Dr. Choate.

Dr. Choate is co-chief of dermatology at the Saint Raphael campus, director of research of the Yale Medicine Department of Dermatology, and an associate director of the Yale Medical Scientist Program. He reports that “having the opportunity to train the next generation of clinicians and physician-scientists who will shape medicine is an inspiring part of what I do.”

In his own research, Dr. Choate employs genetic tool and biologic investigation to find solutions for other genetic disorders such as ichthyosis, palmoplantar keratoderma and disorders appearing in patches or stripes on the skin. These include mosaic manifestations of acne, lichen planus, lupus and psoriasis.

To that end, Dr. Choate has recently published research on a group of severe, genetic skin conditions called ichthyosis, which cause dry, scaly or thickened skin. They affect about 200,000 people and can be disfiguring. In his new research, he and colleagues found a commonly used acne medication called isotretinoin (Accutane), counteracts the effects of the genetic mutations the disorder causes. “In two patients who’ve utilized it, the medication has cured the disease,” Dr. Choate says.

“Yale Medicine’s approach to patient care, disease-centered research, and education gives me a unique opportunity to make a difference in patients’ lives. This is why I come to work every day,” Dr. Choate says.

• Aaron B. and Marguerite Lerner Professor and Chair of Dermatology. Professor of Genetics and Pathology. Associate Dean for Physician-Scientist Development

Education & Training

• Postdoctoral Fellow Yale University School of Medicine (2008)
• Resident Yale- New Haven Hospital (2008)
• Intern Yale-New Haven Hospital (2005)
• MD Yale University School of Medicine (2004)
• PhD Yale University, Cell Biology (2001)
• MPhil Yale University, Cell Biology (2000)
• BS Stanford University, Biological Sciences (1995)

Additional Information

• ICC: Interurban Clinical Club (2018)
• ADA: American Dermatological Association (2017)
• ASCI: American Society for Clinical Investigation (2016)
• Young Investigator Award: American Academy of Dermatology (2011)
• Alpha Omega Alpha: Alpha Omega Alpha (2004)
• AB of Dermatology, Dermatology (2008)
• Associate Director Yale Medical Scientist Training Program (2015 - Present): Director
• Board of Directors, Foundation for Ichthyosis and Related Skin Types (2015 - 2017): Member
• Medical and Scientific Advisory Board, Foundation for Ichthyosis and Related Skin Types (2010 - 2017): Member
• LB974 Mutation spectrum of cutaneous vascular anomalies shah K, Goldust M, Ellis K, Ugwu N, Hu R, Zhou J, Choate K . LB974 Mutation spectrum of cutaneous vascular anomalies. Journal Of Investigative Dermatology 2024, 144: s171. DOI: 10.1016/j.jid.2024.06.1150 .
• Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment Hunt M, Wang N, Pupinyo N, Curman P, Torres M, Jebril W, Chatzinikolaou M, Lorent J, Silberberg G, Bansal R, Burner T, Zhou J, Kimeswenger S, Hoetzenecker W, Choate K , Bachar-Wikstrom E, Wikstrom J. Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment. EMBO Molecular Medicine 2024, 1-16. PMID: 39060641 , DOI: 10.1038/s44321-024-00104-3 .
• Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling Velasco R, Shao C, Cutler B, Strunck J, Kent G, Cassidy P, Choate K , Greiling T. Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling. JAMA Dermatology 2024, 160: 641-645. PMID: 38598229 , PMCID: PMC11007649 , DOI: 10.1001/jamadermatol.2024.0257 .
• Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab Singh K, Breidbart R, Jaiswal A, Damsky W, Choate K , Vesely M. Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab. JAAD Case Reports 2024, 49: 102-105. PMID: 38952857 , PMCID: PMC11214983 , DOI: 10.1016/j.jdcr.2024.05.002 .
• How Efforts to Understand Somatic Mosaicism Will Impact Dermatology Mortlock R, Choate K . How Efforts to Understand Somatic Mosaicism Will Impact Dermatology. Journal Of Investigative Dermatology 2024, 144: 453-455. PMID: 38395493 , PMCID: PMC11009867 , DOI: 10.1016/j.jid.2023.10.007 .
• Topical trametinib for epidermal and sebaceous nevi in a child with Schimmelpenning‐Feuerstein‐Mims syndrome Haller C, Leszczynska M, Brichta L, Maier E, Riddington I, Choate K , Levy M. Topical trametinib for epidermal and sebaceous nevi in a child with Schimmelpenning‐Feuerstein‐Mims syndrome. Pediatric Dermatology 2024, 41: 523-525. PMID: 38273779 , PMCID: PMC11096062 , DOI: 10.1111/pde.15523 .
• In‐person validation of the Ichthyosis Scoring System Echeandia‐Francis C, Sun Q, Asch S, Bayart C, Benjamin L, Cipriano S, Craiglow B, Dyer J, Levy M, Lilly E, Newell B, Liang J, Gan G, Deng Y, Paller A, Choate K . In‐person validation of the Ichthyosis Scoring System. Pediatric Dermatology 2024, 41: 247-252. PMID: 38234066 , DOI: 10.1111/pde.15508 .
• Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin Bolsoni J, Liu D, Mohabatpour F, Ebner R, Sadhnani G, Tafech B, Leung J, Shanta S, An K, Morin T, Chen Y, Arguello A, Choate K , Jan E, Ross C, Brambilla D, Witzigmann D, Kulkarni J, Cullis P, Hedtrich S. Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin. ACS Nano 2023, 17: 22046-22059. PMID: 37918441 , PMCID: PMC10655174 , DOI: 10.1021/acsnano.3c08644 .
• Associations between ichthyosis and mood disorders: A case-control study in the All of Us Research Program Chen G, Goldust M, Choate K , Cohen J. Associations between ichthyosis and mood disorders: A case-control study in the All of Us Research Program. Journal Of The American Academy Of Dermatology 2023, 90: 439-440. PMID: 37863200 , DOI: 10.1016/j.jaad.2023.10.025 .
• Association of Somatic ATP2A2 Damaging Variants With Grover Disease Seli D, Ellis K, Goldust M, Shah K, Hu R, Zhou J, McNiff J, Choate K . Association of Somatic ATP2A2 Damaging Variants With Grover Disease. JAMA Dermatology 2023, 159: 745-749. PMID: 37195706 , PMCID: PMC10193258 , DOI: 10.1001/jamadermatol.2023.1139 .
• Clinical features in adults with acquired cutis laxa: a retrospective review O’Connell K, Schaefer M, Atzmony L, Vleugels R, Choate K , LaChance A, Min M. Clinical features in adults with acquired cutis laxa: a retrospective review. British Journal Of Dermatology 2023, 188: 800-816. PMID: 36849736 , PMCID: PMC10230959 , DOI: 10.1093/bjd/ljad043 .
• Nagashima‐type palmoplantar keratoderma: Case series and two novel variants Braun M, Choate K , Mathes E. Nagashima‐type palmoplantar keratoderma: Case series and two novel variants. Pediatric Dermatology 2023, 40: 882-885. PMID: 36721328 , DOI: 10.1111/pde.15265 .
• Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings Roy S, Sarhan J, Liu X, Murphy M, Bunick C, Choate K , Damsky W, McNiff J. Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings. British Journal Of Dermatology 2022, 188: 574-576. PMID: 36763786 , DOI: 10.1093/bjd/ljac146 .
• 502 The genomic and phenotypic landscape of ichthyosis: An analysis of 1000 kindreds Sun Q, Marukian N, Cheraghlou S, Paller A, Larralde M, Bercovitch L, Levinsohn J, Ren I, Hu R, Zhou J, Zaki T, Fan R, Tian C, Saraceni C, Nelson-Williams C, Loring E, Craiglow B, Milstone L, Lifton R, Boyden L, Choate K . 502 The genomic and phenotypic landscape of ichthyosis: An analysis of 1000 kindreds. Journal Of Investigative Dermatology 2022, 142: s85. DOI: 10.1016/j.jid.2022.05.511 .
• Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders Atzmony L, Ugwu N, Hamilton C, Paller A, Zech L, Antaya R, Choate K . Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders. Pediatric Dermatology 2022, 39: 903-907. PMID: 35853659 , PMCID: PMC9712156 , DOI: 10.1111/pde.15094 .
• Acral hemorrhagic Darier disease: A case report of a rare presentation and literature review Hong E, Hu R, Posligua A, Choate K , Durkin J. Acral hemorrhagic Darier disease: A case report of a rare presentation and literature review. JAAD Case Reports 2022, 31: 93-96. PMID: 36545487 , PMCID: PMC9762068 , DOI: 10.1016/j.jdcr.2022.05.030 .
• 25905 The Ichthyosis Scoring System (ISS): Development and validation of a novel ichthyosis severity assessment instrument Sun Q, Paller A, Choate K . 25905 The Ichthyosis Scoring System (ISS): Development and validation of a novel ichthyosis severity assessment instrument. Journal Of The American Academy Of Dermatology 2021, 85: ab12. DOI: 10.1016/j.jaad.2021.06.073 .
• LB731 GJA4 somatic mutations drive venous malformation in the skin and liver and reveal a novel pathway for therapeutic intervention Ugwu N, Atzmony L, Ellis K, Panse G, Jain D, Ko C, Nassiri N, Choate K . LB731 GJA4 somatic mutations drive venous malformation in the skin and liver and reveal a novel pathway for therapeutic intervention. Journal Of Investigative Dermatology 2021, 141: b8. DOI: 10.1016/j.jid.2021.07.021 .
• 428 Randomized, double-blind, placebo-controlled study of efficacy and safety of secukinumab to treat adults with ichthyoses Lefferdink R, Chima M, Ibler E, Pavel A, Kim H, Wu B, Abu-Zayed H, Rangel S, Wu J, Zumpf K, Jackson K, Choate K , Guttman-Yassky E, Paller A. 428 Randomized, double-blind, placebo-controlled study of efficacy and safety of secukinumab to treat adults with ichthyoses. Journal Of Investigative Dermatology 2021, 141: s74. DOI: 10.1016/j.jid.2021.02.451 .
• 422 The Ichthyosis Scoring System (ISS): Development and validation of a novel ichthyosis severity assessment instrument Sun Q, Paller A, Choate K . 422 The Ichthyosis Scoring System (ISS): Development and validation of a novel ichthyosis severity assessment instrument. Journal Of Investigative Dermatology 2021, 141: s73. DOI: 10.1016/j.jid.2021.02.445 .
• 186 Kindler epidermolysis bullosa-like skin phenotype and downregulated basement membrane zone gene expression in poikiloderma with neutropenia and a homozygous USB1 mutation Vahidnezhad H, Youssefian L, Touati A, Saeidian A, Harvey N, Zabihi M, Barzegar M, Sotoudeh S, Liu L, Guy A, Kariminejad A, Zeinali S, Boyden L, Choate K , McGrath J, Uitto J. 186 Kindler epidermolysis bullosa-like skin phenotype and downregulated basement membrane zone gene expression in poikiloderma with neutropenia and a homozygous USB1 mutation. Journal Of Investigative Dermatology 2021, 141: s33. DOI: 10.1016/j.jid.2021.02.206 .
• 180 ASPRV1 mutations cause dominantly inherited ichthyosis Boyden L, Zhou J, Hu R, Zaki T, Loring E, Scott J, Traupe H, Paller A, Lifton R, Choate K . 180 ASPRV1 mutations cause dominantly inherited ichthyosis. Journal Of Investigative Dermatology 2021, 141: s32. DOI: 10.1016/j.jid.2021.02.200 .
• 868 Pathogenesis based therapy improves cutaneous abnormalities in porokeratosis- A pilot study Azmony L, Sun Q, Hamilton C, Lim Y, Leventhal J, Paller A, Choate K . 868 Pathogenesis based therapy improves cutaneous abnormalities in porokeratosis- A pilot study. Journal Of Investigative Dermatology 2020, 140: s113. DOI: 10.1016/j.jid.2020.03.884 .
• 579 Rationale and design for the Kallikrein Inhibitor in Netherton Syndrome (KINS) pivotal clinical trial Johnson K, Hovnanian A, Teng J, Paller A, Choate K , Elias P, Laura Z, Nguyen T, Smith D, Hsu A, Alani L, Lai C, Hsu L. 579 Rationale and design for the Kallikrein Inhibitor in Netherton Syndrome (KINS) pivotal clinical trial. Journal Of Investigative Dermatology 2020, 140: s79. DOI: 10.1016/j.jid.2020.03.589 .
• 432 Ichthyosis affects mental health in adults and children: A cross-sectional study Sun Q, Ren I, Zaki T, Maciejewski K, Choate K . 432 Ichthyosis affects mental health in adults and children: A cross-sectional study. Journal Of Investigative Dermatology 2020, 140: s57. DOI: 10.1016/j.jid.2020.03.440 .
• 294 Recessive mutations in AP1B1 cause ichthyosis, deafness, and blindness Boyden L, Atzmony L, Zhou J, Lim Y, Hu R, Lifton R, Choate K . 294 Recessive mutations in AP1B1 cause ichthyosis, deafness, and blindness. Journal Of Investigative Dermatology 2020, 140: s36. DOI: 10.1016/j.jid.2020.03.300 .
• 390 Second-hit, post-zygotic PMVKand MVD mutations cause linear porokeratosis Atzmony L, Khan H, Lim Y, Paller A, Levinsohn J, Holland K, Mirza F, Yin E, Ko C, Leventhal J, Choate K . 390 Second-hit, post-zygotic PMVKand MVD mutations cause linear porokeratosis. Journal Of Investigative Dermatology 2019, 139: s67. DOI: 10.1016/j.jid.2019.03.466 .
• 1338 Dermal Wnt/β-catenin activation tunably controls hair follicle initiation Gupta K, Chen D, Levinsohn J, Choate K , Taketo M, Myung P. 1338 Dermal Wnt/β-catenin activation tunably controls hair follicle initiation. Journal Of Investigative Dermatology 2018, 138: s227. DOI: 10.1016/j.jid.2018.03.1355 .
• 655 Origin and functions of the corneocyte lipid envelope Crumrine D, Khnykin D, Krieg P, Man M, Celli A, Mauro T, Menon G, Mauldin E, Miner J, Brash A, Sprecher E, Radner F, Choate K , Roop D, Uchida Y, Gruber R, Schmuth M, Elias P. 655 Origin and functions of the corneocyte lipid envelope. Journal Of Investigative Dermatology 2018, 138: s111. DOI: 10.1016/j.jid.2018.03.664 .
• 379 Quality of life in children with ichthyosis Olamiju B, Ren I, Li L, Deng Y, Marukian N, Zhou J, Hu R, Zaki T, Craiglow B, Choate K . 379 Quality of life in children with ichthyosis. Journal Of Investigative Dermatology 2018, 138: s64. DOI: 10.1016/j.jid.2018.03.385 .
• 799 Exome, genome, and cDNA sequencing reveal KDSR mutations cause two forms of ichthyosis and identify retinoids as pathogenesis-directed therapy Boyden L, Vincent N, Zhou J, Hu R, Paller A, Lifton R, Baserga S, Choate K . 799 Exome, genome, and cDNA sequencing reveal KDSR mutations cause two forms of ichthyosis and identify retinoids as pathogenesis-directed therapy. Journal Of Investigative Dermatology 2018, 138: s136. DOI: 10.1016/j.jid.2018.03.809 .
• Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma Boyden LM, Vincent NG, Zhou J, Hu R, Craiglow BG, Bayliss SJ, Rosman IS, Lucky AW, Diaz LA, Goldsmith LA, Paller AS, Lifton RP, Baserga SJ, Choate KA . Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma. American Journal Of Human Genetics 2017, 100: 978-984. PMID: 28575652 , PMCID: PMC5473720 , DOI: 10.1016/j.ajhg.2017.05.003 .
• 463 GJA1 mutations causing erythrokeratodermia variabilis et progressiva display increased connexin hemichannel activity Khan H, Boyden L, Tomita S, Choate K . 463 GJA1 mutations causing erythrokeratodermia variabilis et progressiva display increased connexin hemichannel activity. Journal Of Investigative Dermatology 2017, 137: s80. DOI: 10.1016/j.jid.2017.02.482 .
• 514 Somatic mutations in nevus comedonicus identify nek9 as a determinant of follicular keratinocyte cell fate Levinsohn J, Sugarman J, McNiff J, Freiden I, Antaya R, Choate K . 514 Somatic mutations in nevus comedonicus identify nek9 as a determinant of follicular keratinocyte cell fate. Journal Of Investigative Dermatology 2017, 137: s88. DOI: 10.1016/j.jid.2017.02.534 .
• 458 Cellular and metabolic basis for the ichthyotic phenotype in ichthyin deficiency Mauldin E, Cassal M, Jeong S, Vavrova K, Uchida Y, Park K, Craiglow B, Choate K , Shin K, Lee Y, Khnykin D, Grove G, Elias P. 458 Cellular and metabolic basis for the ichthyotic phenotype in ichthyin deficiency. Journal Of Investigative Dermatology 2017, 137: s79. DOI: 10.1016/j.jid.2017.02.477 .
• 497 Genetic investigation of linear inflammatory disorders Theodosakis N, Levinsohn J, Lim Y, Paller A, Sugarman J, Choate K . 497 Genetic investigation of linear inflammatory disorders. Journal Of Investigative Dermatology 2017, 137: s85. DOI: 10.1016/j.jid.2017.02.517 .
• 291 Establishing and validating an ichthyosis severity index Marukian N, Deng Y, Gan G, Ren I, Thermidor W, Craiglow B, Milstone L, Choate K . 291 Establishing and validating an ichthyosis severity index. Journal Of Investigative Dermatology 2017, 137: s50. DOI: 10.1016/j.jid.2017.02.307 .
• 513 GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activation Lim Y, Bacchiocchi A, Qiu J, Bruckner A, Bercovitch L, Narayan D, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate K . 513 GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activation. Journal Of Investigative Dermatology 2017, 137: s88. DOI: 10.1016/j.jid.2017.02.533 .
• GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation Lim YH, Bacchiocchi A, Qiu J, Straub R, Bruckner A, Bercovitch L, Narayan D, Genomics Y, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate KA . GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation. American Journal Of Human Genetics 2016, 99: 443-450. PMID: 27476652 , PMCID: PMC4974082 , DOI: 10.1016/j.ajhg.2016.06.010 .
• 392 A novel polyalanine frameshift mutation in KRT10 causes ichthyosis with confetti Lim Y, Saraceni C, Choate K . 392 A novel polyalanine frameshift mutation in KRT10 causes ichthyosis with confetti. Journal Of Investigative Dermatology 2016, 136: s69. DOI: 10.1016/j.jid.2016.02.426 .
• 395 Disease severity and cutaneous inflammation in ichthyosis are linked to Th17 pathway activation Paller A, Suarez-Farinas M, Renert-Yuval Y, Oliva M, Huynh T, Esaki H, Suprun M, Friedland R, Wanderman R, Krueger J, Choate K , Guttman-Yassky E. 395 Disease severity and cutaneous inflammation in ichthyosis are linked to Th17 pathway activation. Journal Of Investigative Dermatology 2016, 136: s70. DOI: 10.1016/j.jid.2016.02.429 .
• 383 A novel erythrokeratodermia-cardiomyopathy syndrome is caused by dominant, clustered mutations in desmoplakin Boyden L, Kam C, Hernández-Martín A, Zhou J, Craiglow B, Milstone L, Hu R, Elias P, Green K, Choate K . 383 A novel erythrokeratodermia-cardiomyopathy syndrome is caused by dominant, clustered mutations in desmoplakin. Journal Of Investigative Dermatology 2016, 136: s68. DOI: 10.1016/j.jid.2016.02.416 .
• 366 Bathing suit ichthyosis: Novel mutations and clues to pathogenesis Marukian N, Zhou J, Hu R, Theos A, Kaymakcalan H, Bayliss S, Paller A, Boyden L, Choate K . 366 Bathing suit ichthyosis: Novel mutations and clues to pathogenesis. Journal Of Investigative Dermatology 2016, 136: s65. DOI: 10.1016/j.jid.2016.02.399 .
• Somatic Mutations in NEK9 Cause Nevus Comedonicus Levinsohn JL, Sugarman JL, Genomics Y, McNiff JM, Antaya RJ, Choate KA . Somatic Mutations in NEK9 Cause Nevus Comedonicus. American Journal Of Human Genetics 2016, 98: 1030-1037. PMID: 27153399 , PMCID: PMC4863661 , DOI: 10.1016/j.ajhg.2016.03.019 .
• Somatic ATP2A2 mutation in a case of papular acantholytic dyskeratosis: mosaic Darier disease Knopp EA, Saraceni C, Moss J, McNiff JM, Choate KA . Somatic ATP2A2 mutation in a case of papular acantholytic dyskeratosis: mosaic Darier disease. Journal Of Cutaneous Pathology 2015, 42: 853-857. PMID: 26154588 , PMCID: PMC4843784 , DOI: 10.1111/cup.12551 .
• Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum Levinsohn JL, Sugarman JL, Bilguvar K, McNiff JM, Choate K , Genomics T. Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. Journal Of Investigative Dermatology 2015, 135: 2536-2538. PMID: 25950823 , PMCID: PMC4567902 , DOI: 10.1038/jid.2015.180 .
• Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti Choate KA , Lu Y, Zhou J, Elias PM, Zaidi S, Paller AS, Farhi A, Nelson-Williams C, Crumrine D, Milstone LM, Lifton RP. Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti. Journal Of Clinical Investigation 2015, 125: 1703-1707. PMID: 25774499 , PMCID: PMC4396494 , DOI: 10.1172/jci64415 .
• Somatic Activating RAS Mutations Cause Vascular Tumors Including Pyogenic Granuloma Lim YH, Douglas SR, Ko CJ, Antaya RJ, McNiff JM, Zhou J, , Choate K , Narayan D. Somatic Activating RAS Mutations Cause Vascular Tumors Including Pyogenic Granuloma. Journal Of Investigative Dermatology 2015, 135: 1698-1700. PMID: 25695684 , PMCID: PMC4430357 , DOI: 10.1038/jid.2015.55 .
• Dominant De Novo Mutations in GJA1 Cause Erythrokeratodermia Variabilis et Progressiva, without Features of Oculodentodigital Dysplasia Boyden LM, Craiglow BG, Zhou J, Hu R, Loring EC, Morel KD, Lauren CT, Lifton RP, Bilguvar K, , Paller A, Choate K . Dominant De Novo Mutations in GJA1 Cause Erythrokeratodermia Variabilis et Progressiva, without Features of Oculodentodigital Dysplasia. Journal Of Investigative Dermatology 2014, 135: 1540-1547. PMID: 25398053 , PMCID: PMC4430428 , DOI: 10.1038/jid.2014.485 .
• Somatic HRAS p.G12S Mutation Causes Woolly Hair and Epidermal Nevi Levinsohn JL, Teng J, Craiglow BG, Loring EC, Burrow TA, Mane SS, Overton JD, Lifton RP, McNiff JM, Lucky AW, Choate KA . Somatic HRAS p.G12S Mutation Causes Woolly Hair and Epidermal Nevi. Journal Of Investigative Dermatology 2013, 134: 1149-1152. PMID: 24129065 , PMCID: PMC3961553 , DOI: 10.1038/jid.2013.430 .
• Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia Lim YH, Ovejero D, Sugarman JS, DeKlotz CM, Maruri A, Eichenfield LF, Kelley PK, Jüppner H, Gottschalk M, Tifft CJ, Gafni RI, Boyce AM, Cowen EW, Bhattacharyya N, Guthrie LC, Gahl WA, Golas G, Loring EC, Overton JD, Mane SM, Lifton RP, Levy ML, Collins MT, Choate KA . Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia. Human Molecular Genetics 2013, 23: 397-407. PMID: 24006476 , PMCID: PMC3869357 , DOI: 10.1093/hmg/ddt429 .
• Whole-Exome Sequencing Reveals Somatic Mutations in HRAS and KRAS, which Cause Nevus Sebaceus Levinsohn JL, Tian LC, Boyden LM, McNiff JM, Narayan D, Loring ES, Yun D, Sugarman JL, Overton JD, Mane SM, Lifton RP, Paller AS, Wagner AM, Antaya RJ, Choate KA . Whole-Exome Sequencing Reveals Somatic Mutations in HRAS and KRAS, which Cause Nevus Sebaceus. Journal Of Investigative Dermatology 2012, 133: 827-830. PMID: 23096712 , PMCID: PMC3556376 , DOI: 10.1038/jid.2012.379 .
• An Incompletely Penetrant Novel Mutation in COL7A1 Causes Epidermolysis Bullosa Pruriginosa and Dominant Dystrophic Epidermolysis Bullosa Phenotypes in an Extended Kindred Yang CS, Lu Y, Farhi A, Nelson-Williams C, Kashgarian M, Glusac EJ, Lifton RP, Antaya RJ, Choate KA . An Incompletely Penetrant Novel Mutation in COL7A1 Causes Epidermolysis Bullosa Pruriginosa and Dominant Dystrophic Epidermolysis Bullosa Phenotypes in an Extended Kindred. Pediatric Dermatology 2012, 29: 725-731. PMID: 22515571 , PMCID: PMC3709244 , DOI: 10.1111/j.1525-1470.2012.01757.x .
• Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10 Choate KA , Lu Y, Zhou J, Choi M, Elias PM, Farhi A, Nelson-Williams C, Crumrine D, Williams ML, Nopper AJ, Bree A, Milstone LM, Lifton RP. Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10. Science 2010, 330: 94-97. PMID: 20798280 , PMCID: PMC3085938 , DOI: 10.1126/science.1192280 .
• Human Hypertension Caused by Mutations in WNK Kinases Wilson F, Disse-Nicodème S, Choate K , Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford D, Lipkin G, Achard J, Feely M, Dussol B, Berland Y, Unwin R, Mayan H, Simon D, Farfel Z, Jeunemaitre X, Lifton R. Human Hypertension Caused by Mutations in WNK Kinases. Science 2001, 293: 1107-1112. PMID: 11498583 , DOI: 10.1126/science.1062844 .
• Claudins Mediate Specific Paracellular Fluxes in Vivo Choate K , Lu Y, Lifton R. Claudins Mediate Specific Paracellular Fluxes in Vivo. 2001 DOI: 10.1201/9781420038538.ch22 .
• Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing Smith A, Skaug J, Choate K , Nayir A, Bakkaloglu A, Ozen S, Hulton S, Sanjad S, Al-Sabban E, Lifton R, Scherer S, Karet F. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Nature Genetics 2000, 26: 71-75. PMID: 10973252 , DOI: 10.1038/79208 .
• Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg2+ Resorption Simon D, Lu Y, Choate K , Velazquez H, Al-Sabban E, Praga M, Casari G, Bettinelli A, Colussi G, Rodriguez-Soriano J, McCredie D, Milford D, Sanjad S, Lifton R. Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg2+ Resorption. Science 1999, 285: 103-106. PMID: 10390358 , DOI: 10.1126/science.285.5424.103 .
• High-Efficiency Gene Transfer and Pharmacologic Selection of Genetically Engineered Human Keratinocytes Deng H, Choate K , Lin Q, Khavari P. High-Efficiency Gene Transfer and Pharmacologic Selection of Genetically Engineered Human Keratinocytes. BioTechniques 1998, 25: 274-280. PMID: 9714888 , DOI: 10.2144/98252gt02 .
• Abnormal Transglutaminase 1 Expression Pattern in a Subset of Patients with Erythrodermic Autosomal Recessive Ichthyosis Choate K , Khavari P, Williams M. Abnormal Transglutaminase 1 Expression Pattern in a Subset of Patients with Erythrodermic Autosomal Recessive Ichthyosis. Journal Of Investigative Dermatology 1998, 110: 8-12. PMID: 9424079 , DOI: 10.1046/j.1523-1747.1998.00070.x .
• Direct Cutaneous Gene Delivery in a Human Genetic Skin Disease Choate K , Khavari P. Direct Cutaneous Gene Delivery in a Human Genetic Skin Disease. Human Gene Therapy 1997, 8: 1659-1665. PMID: 9322868 , DOI: 10.1089/hum.1997.8.14-1659 .
• A Model of Corrective Gene Transfer in X-Linked Ichthyosis Freiberg R, Choate K , Deng H, Alperin E, Shapiro L, Khavari P. A Model of Corrective Gene Transfer in X-Linked Ichthyosis. Human Molecular Genetics 1997, 6: 927-933. PMID: 9175741 , DOI: 10.1093/hmg/6.6.927 .
• Sustainability of Keratinocyte Gene Transfer and Cell Survival In Vivo Choate K , Khavari P. Sustainability of Keratinocyte Gene Transfer and Cell Survival In Vivo. Human Gene Therapy 1997, 8: 895-901. PMID: 9195211 , DOI: 10.1089/hum.1997.8.8-895 .
• Fas Signal Transduction Triggers Either Proliferation or Apoptosis in Human Fibroblasts Freiberg R, Spencer D, Choate K , Duh H, Schreiber S, Crabtree G, Khavari P. Fas Signal Transduction Triggers Either Proliferation or Apoptosis in Human Fibroblasts. Journal Of Investigative Dermatology 1997, 108: 215-219. PMID: 9008237 , DOI: 10.1111/1523-1747.ep12334273 .
• Specific Triggering of the Fas Signal Transduction Pathway in Normal Human Keratinocytes* Freiberg R, Spencer D, Choate K , Peng P, Schreiber S, Crabtree G, Khavari P. Specific Triggering of the Fas Signal Transduction Pathway in Normal Human Keratinocytes*. Journal Of Biological Chemistry 1996, 271: 31666-31669. PMID: 8940187 , DOI: 10.1074/jbc.271.49.31666 .
• Corrective gene transfer in the human skin disorder lamellar ichthyosis Choate K , Medalie D, Morgan J, Khavari P. Corrective gene transfer in the human skin disorder lamellar ichthyosis. Nature Medicine 1996, 2: 1263-1267. PMID: 8898758 , DOI: 10.1038/nm1196-1263 .
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Lauryn Marlene Falcone , MD , PhD

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Lauryn Falcone, MD, is a dermatologist and is board eligible in dermatology by the American Academy of Dermatology. She received her medical degree from West Virginia University School of Medicine and completed her residency at the University of Pittsburgh.

Dr. Falcone’s clinical interests include medical and surgical dermatology, cosmetic dermatology, general dermatology, and dermatologic oncology.

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Paul Nghiem MD PhD

Academic Office Department of Dermatology UW Medical Center 1959 NE Pacific St. BB-1332 Health Sciences Box 356524 Seattle, WA 98195

Research Office Nghiem Lab UW Medicine at South Lake Union 850 Republican St. Box 358050 Seattle, WA 98109

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South Lake Union Clinic 825 Eastlake Ave E Seattle, WA 98109

Paul Nghiem, MD, PhD, (he/him/his) is a board certified physician at the Fred Hutchinson Cancer Center, Founding Chair of the UW Department of Dermatology, the George F. Odland Endowed Chair in Dermatology, and a UW professor of Medicine and Dermatology and an adjunct professor in the Departments of Laboratory Medicine and Pathology as well as Oral Health Sciences. Dr. Nghiem oversees the  Nghiem Lab , a laboratory focused on the biology of skin cancer. Dr. Nghiem earned his MD and PhD at Stanford. His clinical and research interests include dermatology, Merkel cell carcinoma, melanoma, graft versus host disease and complex skin cancer management in a multidisciplinary team.

Dr. Nghiem holds the following leadership roles in the Dermatology and Skin Oncology community:

• Director, Skin Oncology Clinical Program, Fred Hutchinson Cancer Center
• Deputy Director for Seattle Translational Tumor Research, Skin/Cutaneous Oncology
• Secretary-Treasurer, Society for Investigative Dermatology

Education & Training

MD, Stanford University School of Medicine, Stanford CA, 1994

PhD, Stanford University, Program in Cancer Biology, Stanford CA, 1994

AB, Biological Sciences, Harvard University, Boston MA, 1986

Research Interests

A major portion of the Nghiem lab is primarily focused on basic, clinical and translational research aspects of Merkel cell carcinoma. We are involved in several clinical studies on this increasingly common and often lethal skin cancer to determine its basic genetic underpinnings as well as its clinical course and optimal management. The  Merkel cell carcinoma  Multicenter Interest Group (MMIG), is an international collaborative group, has been formed to leverage diverse resources, interests and expertise to make a difference in this cancer.

A second research interest is focused on skin cancer biology, particularly the molecular mechanism by which the protein kinase ATR mediates an essential cell cycle arrest following DNA damage such as by ultraviolet radiation.  It appears that the skin cancer preventive effect of caffeine is mediated by its inhibition on the ATR-Chk1 pathway, hence eliminating UV-damaged cells from the skin.

Clinical Interests

• Merkel cell carcinoma
• Graft vs. host disease of the skin

Publications

Selected publications.

Dr. Nghiem has over 170 publications that have been cited 10,907 times as of August 5, 2019, with an h-index of 54 and an i10-index of 122 according to  Google Scholar .

Heath, M; Jaimes, N; Lemos, B;  Mostaghimi, A; Wang, L C; Peñas, P F;  Nghiem, P ; Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.  Journal of the American Academy of Dermatology . 58 (3): 375-381, 2008. Cited 793 times

Bianca D Lemos, Barry E Storer, Jayasri G Iyer, Jerri Linn Phillips, Christopher K Bichakjian, L Christine Fang, Timothy M Johnson, Nanette J Liegeois-Kwon, Clark C Otley, Kelly G Paulson, Merrick I Ross, Siegrid S Yu, Nathalie C Zeitouni, David R Byrd, Vernon K Sondak, Jeffrey E Gershenwald, Arthur J Sober, Paul Nghiem . Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.  Journal of the American Academy of Dermatology . 63(5): 751-761, 2010. Cited 506 times

Paulson, K G; Carter, J J; Johnson, L G; Cahill, K W; Iyer, J G; Schrama, D; Becker, J C; Madeleine, M M;  Nghiem, P ; Galloway, D A. Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.  Cancer Research.  70(21): 8388-8397. 2010. Cited 192 times

Afanasiev, O K; Yelistratova, L; Miller, N; Nagase, K; Paulson, K; Iyer, J G; Ibrani, D; Koelle, D M;  Nghiem, P . Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.  Clinical Cancer Research . 19(19): 5351-5360, 2013. Cited 149 times

Nghiem, P T ; Bhatia, S; Lipson, E J; Kudchadkar, R R; Miller, N J; Annamalai, L; Berry, S; Chartash, E K; Daud, A; Fling, S P. PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma.  New England Journal of Medicine . 374(26): 2542-2552, 2016. Cited 763 times

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Board-Certified Dermatologist

Ha Linh Vu, MD, PhD is a board-certified dermatologist who practices medical, surgical, and cosmetic dermatology in patients of all ages. She has a special interest in the treatment of skin cancer.

Dr. Vu received her undergraduate degree from Dartmouth College, where she was a member of Phi Beta Kappa and graduated summa cum laude. She furthered her education at Thomas Jefferson University, earning both her M.D. and Ph.D. degrees. During her time there, she was recognized as a distinguished member of the Hobart Armory Hare Medical Honor Society and garnered accolades for her research dedicated to melanoma. Following a preliminary medicine year at Einstein Medical College, Dr. Vu successfully completed her dermatology residency at New York Presbyterian Columbia University Irving Medical Center.

She is a fellow of the American Academy of Dermatology and the American Medical Association.

Born in Vietnam and raised in New York City, Dr. Vu holds a deep affection for Philadelphia, which she proudly calls home. Outside of work, she finds joy in various hobbies including traveling, culinary arts, yoga, hiking, and embarking on culinary adventures at Philadelphia’s diverse array of restaurants with her husband.

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Dr. Michael Nazareth

Md/phd/faad, board certified dermatologist.

Michael Nazareth is the president of Western New York Dermatology and a board certified dermatologist. He was born and raised in Buffalo and attended St. Joe’s Collegiate Institute for High School. He earned a BS in biology at Canisius College and then went on to the State University of New York at Buffalo School of Medicine and Biomedical Sciences, where he earned his MD and PhD degrees. He then completed a dermatology residency at SUNY Buffalo, during which time he trained at Roswell Park Cancer Institute, Women and Children’s Hospital of Buffalo, Buffalo General Medical Center and the Veterans Administration Hospital. He was chief resident in the final year of his residency training. Dr. Nazareth is a member of the American Academy of Dermatology, the Society for Pediatric Dermatology, the American Society for Dermatologic Surgery, the American Medical Association and the Medical Society of the State of New York. Dr. Nazareth looks forward to working closely with patients of all ages to meet their complete dermatologic needs by offering a comprehensive range of medical, surgical, and cosmetic treatments.

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Dermatology Resident Awarded a $1 Million Research Grant to Develop a Comprehensive Molecular Map of Hidradenitis Suppurativa

Updated on Sep 11, 2024 | Featured , Research

Kristina Navrazhina, MD, PhD

Kristina Navrazhina, MD, PhD, a first-year dermatology resident at the Icahn School of Medicine at Mount Sinai, has received a $1 million grant for research to provide a comprehensive molecular map of hidradenitis suppurativa (HS) —a skin condition that causes painful lumps deep in the skin—that may define specific subtypes and identify novel therapeutic targets.

Emma Guttman, MD, PhD , the Waldman Professor and Chair of Dermatology and Immunology at the Icahn Mount Sinai, is Co-Principal Investigator on this study.

“Hidradenitis suppurativa is a chronic, debilitating inflammatory skin disease with a highly unmet therapeutic need. There are currently no standardized HS biomarkers, which delays diagnosis and the monitoring of treatment response,” says Dr. Guttman.

Patients present with painful inflamed nodules and abscesses that progress to draining tunnels, commonly affecting places where two skin areas may touch or rub together, such as the armpits or the groin. The disease has an average onset of early adulthood and disproportionately affects underserved communities.

Despite the profound impact on the quality of life, there is still a high unmet need for better treatments. “This grant gives our team the opportunity to discover novel therapeutic options to help bridge this gap,” say Dr. Navrazhina. The grant is from Sanofi, the Paris-based pharmaceutical company.

Molecular mapping may identify early biomarkers of disease progression and capture an earlier window of opportunity for therapeutic intervention. Minimally invasive approaches of tape stripping to collect thin layers of skin and blood serum biomarker analysis will be used to study the molecular profile of HS. The data gathered from this research has the potential to connect clinical practice and therapeutic trials, thereby developing innovative and individualized treatment for HS.

Dr. Navrazhina adds, “We are inspired by our patients to conduct ground-breaking research that can ultimately be used to improve the quality of life for all HS patients.”

“This grant award highlights how the Kimberly and Eric J. Waldman Department of Dermatology at Mount Sinai is encouraging and fostering young physician/scientists to become leading scientific investigators of the future,” says Dr. Guttman.

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Sanofi Reports High Efficacy in Dupilumab for BP

New study results show promise in dupilumab for bullous pemphigoid, with 59% of patients avoiding disease relapse.

Image Credit: © Creative Endeavors - stock.adobe.com

Dupilumab (Dupixent; Sanofi) has demonstrated “significant” efficacy in treating bullous pemphigoid (BP), according to results from the ADEPT study reported in a press release today. This phase 2/3 trial, involving 106 adults with moderate to severe BP, met its primary and all key secondary endpoints, showcasing dupilumab’s potential as a transformative treatment for BP. 1

“The itchy blisters caused by bullous pemphigoid can be so intense they are debilitating, especially for elderly patients. There is a significant unmet medical need for new medicines for people suffering with this hard-to-treat disease in which the standard of care is oral and topical corticosteroids and immunosuppressants – treatments that have poor clinical outcomes and safety concerns, respectively, and should be used sparingly in an elderly population,” Dietmar Berger, MD, PhD, chief medical officer and global head of development at Sanofi, said in the release. “These positive pivotal results for bullous pemphigoid add to an immense body of scientific evidence that underscores the important role IL-4 and IL-13 play in driving diseases characterized by itch. Combined with the consistent safety profile of the other dermatology indications, these results show the potential of Dupixent to transform the treatment paradigm for bullous pemphigoid.”

According to the release, the ADEPT study revealed that patients receiving dupilumab experienced sustained disease remission at a rate 5 times higher than those on placebo. Sustained disease remission was defined as complete clinical remission with the discontinuation of oral corticosteroids by week 16, without relapse or need for rescue therapy during the 36-week treatment period. Specifically, the company stated that 20% of dupilumab treated patients achieved sustained remission compared to just 4% in the placebo group.

More highlights of the study included:

In terms of safety, the release stated that the overall rate of adverse events was similar between dupilumab and placebo groups. However, some adverse effects, such as peripheral edema and arthralgia, were reported more frequently in the dupilumab group. Importantly, the company reported no deaths attributable to dupilumab, compared to 2 in the placebo group.

“Bullous pemphigoid is a debilitating skin disease with a high mortality rate due to infection. Dupixent is the first medication to show significant and robust impacts in this patient population,” George Yancopoulos, MD, PhD, board co-chair, president, and chief scientific officer at Regeneron, said in the release. “These latest pivotal results reaffirm the underlying role type-2 inflammation plays in driving multiple skin diseases. We look forward to further advancing this research and sharing the positive results from the bullous pemphigoid pivotal trial with regulatory authorities.”

The release stated the positive results from the ADEPT study build on dupilumab’s existing orphan drug designation from the US Food and Drug Administration for BP and will support global regulatory submissions, starting with the US later this year.

In addition to BP, dupilumab is also under investigation for other conditions, including chronic pruritus of unknown origin (CPUO). 2 A related phase 3 study did not meet its primary endpoint for itch reduction but showed promising results in secondary measures related to itch improvement.

Dupilumab has already been approved in over 60 countries for various indications, such as atopic dermatitis and asthma. With over one million patients treated worldwide, Sanofi stated that dupilumab's ongoing research aims to expand its benefits to additional conditions, potentially revolutionizing treatment paradigms for several serious skin diseases.

The detailed results from both the BP and CPUO studies are expected to be presented at an upcoming medical conference, according to the release.

• Dupixent is the first and only biologic to achieve significant improvements in disease remission and symptoms in bullous pemphigoid positive pivotal study. News Release. Sanofi. September 11, 2024. Accessed September 11, 2024. https://www.sanofi.com/en/media-room/press-releases/2024/2024-09-11-05-00-00-2944237
• Efficacy and safety of subcutaneous dupilumab for the treatment of adult participants with chronic pruritus of unknown origin (CPUO) (Liberty-CPUO-chic). Clinical Research Studies Listing. Accessed September 11, 2024. https://www.sanofistudies.com/us/en/listing/291216/efficacy-and-safety-of-4/ .

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About Yakir Levin, MD, PhD

Yakir Levin, MD, PhD  is a board-certified dermatologist, Assistant Professor of Dermatology, and physician scientist at MGH, where he practices medical, laser, and cosmetic dermatology.  Before joining the faculty, he completed a 2-year fellowship in laser and cosmetic procedures at MGH’s Dermatology Laser and Cosmetic Center, one of the world’s leading cosmetic centers.   Dr. Levin graduated summa cum laude from Yeshiva University, where he earned a BA in Physics.  He was accepted to the Medical Scientist Training Program at Stanford University  and completed his MD  at  the School of Medicine, and his MS and PhD degrees in Electrical Engineering at the School of Engineering.  His work focused on development of novel MRI technologies to non-invasively detect and monitor cancer and kidney disease. Dr. Levin completed his internship at Emory University and his residency in dermatology at Boston University Medical Center, where he served as chief resident. While at BU Medical Center, Dr. Levin received the Marie-France Demierre Award for Humanism.

Currently a member of the laboratory of Professor R. Rox Anderson at the Wellman Center for Photomedicine at MGH, Dr. Levin’s research endeavors to improve the quality of life of patients with disfiguring birthmarks and hyperhidrosis, and to develop new platform technologies for the treatment of a variety of dermatologic diseases. He belongs to several professional organizations including the American Academy of Dermatology, the Society of Investigative Dermatology, American Society for Laser Medicine and Surgery and the American Society for Dermatologic Surgery. Dr. Levin specializes in the treatment of vascular and pigmented birthmarks in children, and in performance of laser and cosmetic procedures to address clinical signs of aging. In addition to general medical dermatology, Dr. Levin’s interests include skin cancer, hyperhidrosis, and pigmentary disorders.

Departments, Centers, & Programs:

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Clinical Interests:

• Cosmetic dermatology
• Dermatology (general)
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• Vitiligo and pigmentary disorders
• Adult & Pediatrics

Mass General Dermatology 50 Staniford St. Boston , MA   02114 Phone: 617-726-2914

Mass General Dermatology: Laser and Cosmetic Center 50 Staniford St. Suite 250 Boston , MA   02114 Phone: 617-724-6960

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• Residency, Boston Medical Center
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Treatment of Pyoderma Gangrenosum With Vilobelimab

• 1 University of Cincinnati College of Medicine, Cincinnati, Ohio
• 2 InflaRx GmbH, Munich, Germany
• 3 Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus

Pyoderma gangrenosum (PG) is a rare neutrophilic inflammatory skin condition that results in the development of rapidly progressing cutaneous ulcerations. 1 There are currently no US Food and Drug Administration–approved medications for the treatment of PG. Existing mainstay treatments include corticosteroids, cyclosporine, and biologics such as tumor necrosis factor (TNF) and interleukin-1 (IL-1) inhibitors. 1 , 2 We report a case of PG successfully treated with vilobelimab, an anticomplement factor 5a (C5a) antibody approved for SARS-CoV-2 infections.

Read More About

Himed S , Tawfik H , Kaffenberger BH. Treatment of Pyoderma Gangrenosum With Vilobelimab. JAMA Dermatol. 2024;160(8):898–899. doi:10.1001/jamadermatol.2024.1775

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Comprehensive dermatology care by board-certified dermatologists

At Forefront Dermatology, our team of board-certified medical, cosmetic, and surgical dermatologists offers a highly personalized approach to meeting all of your skin care needs. Our office s in Columbia, Maryland are right around the corner when you need us. We provide comprehensive dermatology care, including both medical and cosmetic treatments with exceptional patient experience.

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*Hours are subject to change, please call to confirm.

Skin care services offered in Columbia, Maryland

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*We accept most major insurance carriers but not all of their products. We recommend you confirm your in-network status of your health plan with your insurance carrier. If you do not see your carrier, please contact our office at 410-772-0707 or contact your carrier to confirm the network status of our practice.

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Mental health, AI and inclusive health care among topics at Big Ideas conference

Experts from academia, industry, the humanities and more gathered on the Stanford Medicine campus to pitch their concepts for the future of medicine.

September 10, 2024 - By Hanae Armitage

Vivek Murthy and Anna Lembke discuss approaches to improving mental health. Steven Truong

From curing all diseases, to consulting patients on new approaches to health care, to using data from social media in training diagnostic algorithms, experts from health care, the tech industry, humanities and more explored what the future of health care could look like at the Big Ideas in Medicine conference Sept. 6 and 7.

“Big ideas are really important,” said Bryant Lin , MD, a clinical professor of primary care and population health who welcomed attendees at Stanford Medicine’s Li Ka Shing Center for Learning and Knowledge. “I want to share a couple of stories of what I think a big idea is today.” Although he has never smoked, he told the audience, he was diagnosed with stage 4 metastatic lung cancer earlier this year.

“I was in pretty bad shape. I had to be hospitalized. But I look pretty good today — I can talk, not short of breath, not coughing. I’m here today because of a big idea in medicine, which is tyrosine kinase inhibitors,” Lin said of a cancer treatment that blocks proteins controlling cell growth and division. “I attribute my ability to have a high quality of life, to be able to be here and share this conference with you and listen to our fantastic speakers…[to] this really big idea.”

Speakers at the two-day event , sponsored by the Medical Humanities and the Arts Program , discussed a variety of topics that encouraged attendees to reimagine what the health care field could look like, if only some of their big ideas came to fruition. The ideas included using AI to create new antibiotics; the value of compelling, accurate science storytelling; retooling the ever-cumbersome electronic health record; and treating anxiety as a stage of grief.

Addressing the mental health crisis

Vivek Murthy, MD, surgeon general of the United States, shined a light on something he’s called “the loneliness epidemic.” From CEOs, members of Congress and parents, Murthy has heard about isolation and feelings of being disconnected. “I realized there was something important happening here,” he said. About 1 in 3 Americans struggle with loneliness. Not only does loneliness increase the chance of developing depression and anxiety and contribute to suicide, it impacts physical health, raising risk for cardiovascular disease, dementia among older people and premature death, Murthy said. It was clear “that loneliness was a public health concern that’s just as important as any traditional concerns, like smoking and obesity,” he said.

What’s missing is quality social connection, the decline of which is likely a result of social media. “I worry that the people who are paying the greatest price for this are young people,” Murthy said. He argues that safety standards and healthy boundaries on technology use are necessary to protect young people and help them build social skills. “When our kids are involved, we have to prioritize safety,” Murthy said. Yet there’s a lack of guardrails for infinite scrolling, visuals that depict self-harm and other problematic content. “That reflects, in my mind, a failure for us to fulfill our most sacred responsibility — to take care of our children.”

Mental health was a theme throughout the conference, with several speakers focusing on physician wellness. It’s no secret that health systems nationally are contending with physician burnout, and the pandemic only exacerbated the problem. Among the outsized contributors: electronic health records, patient messaging and an overall dearth of providers across the country, according to Lisa Rotenstein, MD, and Megan Mahoney, MD, primary care physicians at the University of California, San Francisco, and others. The distribution of a patient’s care among various doctors and health systems can harm patients and increase stress for physicians trying to navigate a patient’s complicated medical history.

Lloyd Minor, MD, dean of the Stanford School of Medicine, addresses conference attendees. Kevin Meynell

Those factors contribute to another pervasive challenge in health care — access to care.

Though these problems loom large, health care and technology experts are determined to find — or create — new short- and long-terms solutions that build a multipronged support system equally beneficial for patients and providers.

Improving access, inclusion and wellness

Ilana Yurkiewicz , MD, clinical assistant professor of primary care and population health, has taken a special interest in care fragmentation, in which several clinicians care for one patient without sharing information. The solution, she said, involves “the three Ts,” — technology, team and time.

According to Yurkiewicz and others, technology must evolve to meet the needs of doctors and patients, such as shareable electronic health records and other tools they can customize as well as consistent coworkers who work with the same teams. If the first two Ts — technology and team — are successfully addressed, ideally, physicians will have the time they need to provide quality care without overextending themselves. (According to the conference’s keynote speaker Amir Rubin, former president and CEO of Stanford Hospital and now CEO of Healthier Capital, health care systems need “the five As” — accessibility, availability, affordability, accommodation and acceptability.)

Yurkiewicz said that Stanford Coordinated Care , a program for patients with multiple health conditions, embraces the three Ts. Under the program, a physical therapist, a nurse, a social worker, a pharmacist, a dietitian and four care coordinators — all of whom are medical assistants trained on relevant health care tech such as electronic health records — work closely with the physicians. “This is just one example of a successful clinic,” she said.

Rotenstein and others also pointed to technology such as AI-based algorithms that take clinical notes for the doctor and draft patient emails for them to review as near-term solutions.

Holly Tabor , PhD, professor of primary care and population health, emphasized the need to make care more accessible for people with intellectual and developmental disabilities. “Everybody thinks it’s somebody else’s job to take care of this population,” Tabor said. “Health care providers, health systems and society have a moral, ethical and legal obligation to make health care more accessible to full participation by people with all forms of disability.”

Tabor and her colleagues have piloted a project, IDD Transform , to improve health outcomes for adults with disabilities in a measurable way. “We need to listen to people with [disabilities] and their caregivers about what they need, what their barriers are, what they’re not getting, and then use design thinking and other models to think about how we can do a better job.”

Bold solutions

“How can we allow you to be your most creative self?” asked Priscilla Chan, MD, co-founder and co-CEO of the Chan Zuckerberg Initiative. “How can we de-risk things, make things faster so that you can pursue your wildest ideas instead of your safest ideas…?”

Eleni Linos enjoying a speaker’s talk. Kevin Meynell

The self-stated goal of the initiative, to “cure, prevent and manage” all diseases, sounds lofty, the panelists said, so it’s not uncommon for people to hear that and balk. In science, people aren’t used to thinking about progress on a 100-year timescale, said Stephen Quake , PhD, professor of bioengineering and applied physics, the Lee Otterson Professor in the School of Engineering, and head of science for the Chan Zuckerberg Initiative. But maybe they should start. “We think of grant-level, three-year timescales,” he said during a conversation with Chan. “Part of the initial reaction of skeptical people [is] they’re just not used to thinking about what happens over the course of 100 years. And if you get kind of scholarly about that, you realize a whole lot can happen in 100 years.”

Researchers shared a variety of other tantalizing ideas for the future of health and medicine. James Zou , PhD, associate professor of biomedical data science, spoke about the evolution of AI, from a predictive puzzle solver to a tool that accelerates research by generating protein sequences for therapeutics, creating images, spitting out text or supplying a variety of other products. Boris Heifets , MD, PhD, associate professor of anesthesiology, perioperative and pain medicine, shared his exploration of psychedelics in mental health management. And Anna Lembke , MD, professor of psychiatry and behavioral sciences, introduced a new type of self-restriction known as “dopamine fasting,” which requires a person to resist behaviors that release the hormone dopamine (like scrolling through social media or eating junk food) to curb addiction and restore dopamine balance in the brain.

Eleni Linos , MD, DrPH, professor of dermatology, took the stage as a storyteller. In May, Palo Alto, California, was treated to a rare celestial phenomenon: the northern lights. Linos begrudgingly joined a friend for a late-night stroll to a dark hill on campus, only to look up at the sky and see…nothing. “As I started to leave, someone I didn’t know tapped me on the shoulder. They said, ‘No, no, no, take out your phone,’” recalled Linos, the Ben Davenport and Lucy Zhang Professor in Medicine. She found that her phone could capture the beautiful pinks and greens streaming across the sky. “That was the moment where I was like, ‘Oh, this is real-life, augmented reality. This is exactly how it should be in my clinic.’” An AI-enabled app on a doctor’s smartphone, for instance, could scans skin lesions and help them make diagnoses based on details unseeable by the naked eye.

Linos added that years ago, on a flight, she sat next to a blind passenger. Her first reaction was to help — did he need assistance maneuvering around the plane? Pouring his drink? He did not. (It turned out he was a motivational speaker named Hoby Wedler who shared ideas about accessibility and science. He even earned a PhD in organic chemistry by feeling the relationships between molecules.) They struck up a conversation.

“We were flying to the East Coast, so we had a really in-depth conversation about accessibility and how educational institutions need to give more opportunities to people with disabilities, including blindness,” Linos said. They talked about her work as a dermatologist and concluded jokingly that there are some fields that would be extra difficult for a blind person to do. There could never really be a blind dermatologist, they agreed.

Fast forward five years. “That’s totally changed. Algorithms aren’t just as good as a dermatologist; in many cases, they’re better.” Linos reached out to Wedler. “I called him, and I was like, ‘You know what? We were wrong five years ago. You could become a dermatologist.’”

“He doesn’t want to,” she said with a laugh. But it poses new questions for Linos: What does it mean for dermatologists’ practice and careers? What will be possible in five years that isn’t today? “I just want to leave you with that optimism and that question.”

About Stanford Medicine

Stanford Medicine is an integrated academic health system comprising the Stanford School of Medicine and adult and pediatric health care delivery systems. Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. For more information, please visit med.stanford.edu .

The majestic cell

How the smallest units of life determine our health

Department of Medicine

A community resource for faculty and staff

• Announcements

Welcome New DoM Faculty

Omid Amidi, MD

Doctor of Medicine: SUNY Downstate College of Medicine, Brooklyn, NY

Residency: Baylor College of Medicine, Houston, TX

Fellowship: University of California, Los Angeles

Nicholas Brownell, MD

Doctor of Medicine Emory University School of Medicine

Internal Medicine Residency: University of Texas Southwestern Medical Center

Cardiology Fellowship: David Geffen School of Medicine at UCLA

Priscilla Hsue, MD

Doctor of Medicine University of California, San Francisco

Residency: University of California, San Francisco

Cardiology Fellowship: University of California, San Francisco

Sami J. Natour, MD

Doctor of Medicine: University of Virginia School of Medicine

Residency: University of California, Los Angeles

Saate Saiyara Shakil, MD, MS

Doctor of Medicine: Albert Einstein College of Medicine

Fellowship: University of California, San Francisco

Justin Sharim, MD

Doctor of Medicine: David Geffen School of Medicine at UCLA

Residency: UCSD Medical Center, San Diego, CA

Fellowship: Harbor-UCLA Medical Center, Los Angeles, Ca

Justin Slade, MD

Doctor of Medicine: Boston University School of Medicine

Residency: Stanford University Hospital

Fellowship in Cardiovascular Medicine: Kaiser Permanente Northern California

Fellowship in Interventional Cardiology: University of California, Los Angeles

Radi Zinoviev, MD, MBA

Doctor of Medicine: Yale University

Residency: Johns Hopkins Hospital

Fellowship in Cardiovascular Disease: The Cleveland Clinic

CLINICAL IMMUNOLOGY & ALLERGY

Connie Lin, MD

Doctor of Medicine: University of California, Irvine, School of Medicine

Internal Medicine Residency: Cedars-Sinai Medical Center & West LA Veterans Affairs Hospital  

Allergy & Immunology Fellowship: University of California, Los Angeles

CLINICAL NUTRITION

Devesha H. Kulkarni, PhD

Doctor of Philosophy: Technische Universität Carolo-Wilhelmina zu Braunschweig

Fellowship: Washington University

DERMATOLOGY

Iris Ahronowitz, MD

Doctor of Medicine: University of California, San Francisco School of Medicine

Larissa Larsen, MD

Doctor of Medicine: Chicago medical School at Rosalind Franklin University of Medicine & Science

Residency: University of California, Davis

Louise Stewart, MD

Doctor of Medicine: Case Western Reserve Univenity School of Medicine

Residency: Harbor-UCLA Medical Center

Fellowship: University of New Mexico Hospital

DIGESTIVE DISEASES

Shida Haghighat, MD

Doctor of Medicine: University of Miami, Miller School of Medicine

Residency: University of Southern California/LAC+USC Medical Center

Fellowship: University of Miami/Jackson Memorial Hospital

Kevork Khadarian, MD

Doctor of Medicine: Albany Medical College

Residency: LAC+USC Medical Center/Keck Medical Center of USC

Fellowship: Mayo Clinic

Anthony Myint, MD

Doctor of Medicine: Keck School of Medicine of the USC

Bao Sean Nguyen, MD

Doctor of Medicine: Keck School of Medicine of USC

Fellowship: University of California, Davis

Devin Patel, MD

Doctor of Medicine: Jefferson Medical College of Thomas Jefferson University

Residency: Cedars-Sinai Medical Center

Carmille Soroudi, MD

Doctor of Medicine: David Geffen School of Medicine (UCLA), Los Angeles CA

ENDOCRINOLOGY

Maralee Kanin, MD

Doctor of Medicine: Chicago Medical School- Rosalind Franklin University

Residency: UCLA-Olive View Medical Center

Nikita Mogar, MD

Doctor of Medicine: State University of New York, Downstate College of Medicine

Residency: NYU Langone Health

Thaer Othman, MD

Doctor of Medicine: Keck School of Medicine of the University of Southern California

Residency: USC Internal Medicine Residency

Fellowship: University of California, Irvine

Henry Zelada Castro, MD

Doctor of Medicine: Universidad Peruana Cayetano Heredia

Residency: Louis A. Weiss Memorial Hospital, University School of Illinois at Chicago

Fellowship: Barnes-Jewish Hospital, Washington University School of Medicine in St. Louis

GENERAL INTERNAL MEDICINE / HEALTH SERVICES RESEARCH

Natalie Abrahamian, MD

Doctor of Medicine: St. George's University School of Medicine

Internal Medicine Residency: University of California, Riverside

Doctor of Medicine: Lewis Katz School of Medicine

Naomi Duncan, MD

Residency: Olive View-UCLA

Clarence Lee, MD

Doctor of Medicine: University of California, Davis, School of Medicine

Marilyn McGowan, MD

Doctor of Medicine: Georgetown University School of Medicine

Residency: Stanford Hospital and Clinics

Sarah Takimoto, MD

Shatara "Tara" Townes, MD

Doctor of Medicine: David Geffen School of Medicine (DGSOM) at UCLA

Residency: University of California, Los Angeles Medical Center

Yatindra Patel, MD

Doctor of Medicine: Case Western Reserve University School of Medicine

Akshay Syal, MD

Doctor of Medicine: New York Medical College

Residency: Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health Lenox Hill Hospital

Douglas Wilson, MD

Doctor of Medicine: University of Washington School of Medicine, Seattle Washington

Residency: Ventura County Medical Center, Ventura California

Alexandra Zindman, MD

Residency: Montefiore Medical Center - Moses & Weiler Campuses

GIM/HSR - ADDICTION MEDICINE

Maya Appley, MD, MPH

Doctor of Medicine: Tulane University School of Medicine, New Orleans, LA

Fellowship: Massachusetts General Hospital, Boston, MA

GIM/HSR - EAST WEST MEDICINE

Mary Fok, MD

Doctor of Medicine: University of Alabam at Birmingham School of Medicine

Sungjin Kuon, DO

Doctor of Osteopathic Medicine: Western University of Health Sciences, College of Osteophatic Medicine of the Pacific (COMP)

Residency: Kent Hospital Family Medicine

GIM/HSR - EXTENSIVIST

Madeline Treasure, MD

Doctor of Medicine: University of North Carolina School of Medicine

Lisle Winston, MD

Doctor of Medicine: Weill Cornell Medical College

Residency: Department of Medicine, Columbia University

GIM/HSR - FAMILY MEDICINE

Charis Bush, DO

Doctor of Osteopathic Medicine: A.T. Still University School of Osteopathic Medicine

Residency: Mercy Medical Center

Shirley Chang, DO

Doctor of Osteopathic Medicine: Midwestern University – Arizona College of Osteopathic Medicine

Residency: Marian Regional Medical Center

Melody Fulton, DO

Doctor of Osteopathic Medicine: West Virginia School of Osteopathic Medicine

Virginia Hernandez, MD

Doctor of Medicine: St. Matthew's University (Grand Cayman), Cayman Islands

Residency: Souther Illinois University School of Medicine

Fellowship: AAFP National Institute for Program Director Development

Michael Pin, MD

Doctor of Medicine: University of Southern California

Azar Razikeen, MD

Doctor of Medicine: Wayne State University School of Medicine

Residency: Adventist Health Glendale

GIM/HSR - MEDICINE-PEDIATRICS

Mark Benor, MD

Doctor of Medicine: Drexel University College of Medicine

Residency: Harbor UCLA Family Medicine

Donya Farmand, MD, MPH

Doctor of Medicine: American University of the Caribbean School of Medicine, Saint Maarten

Residency: Dignity Health California Hospital Family Medicine

Jorge Flautero, MD

Residency: Georgetown-Medstar Health Family Medicine at Fort Lincoln

Mae Huo, MD

Residency: Albany Medical College

Katelyn Klein, MD

Jeffrey Laterreur, MD

Doctor of Medicine: American University of the Caribbean School of Medicine

Residency: VCU Riverside Family Medicine Residency Program

Mike Oulashian, MD

Doctor of Medicine: American University of the Caribbean

Residency: Saint Joseph Family Medicine Residency Program

Jennifer Roberts-Kelly, DO

Doctor of Osteopathic Medicine: Lake Erie College of Osteopathic Medical School

Kashia A. Rosenau, PhD

Doctor of Philosophy: University of California, Los Angeles

Brian Young, MD

Doctor of Medicine: David Geffen School of Medicine, University of California, Los Angeles

Christian Haro Ramirez, MD

Doctor of Medicine: Autonomous University of Guadalajara

Residency: Long Beach Memorial Family Medicine

Fellowship: Icahn School of Medicine at Mount Sinai

HEMATOLOGY-ONCOLOGY

Aditya Bardia, MD, MPH, FASCO

MBBS: All India Institute of Medical Sciences (AIIMS), New Delhi, India

Residency: Mayo Clinic, Rochester, MN

Fellowship: Johns Hopkins Kimmel Cancer Center, Baltimore, MD

Aaron Burkenroad, MD

Doctor of Medicine: Albert Einstein College of Medicine 

Residency: David Geffen School of Medicine at UCLA 

Fellowship: David Geffen School of Medicine at UCLA

Caroline Chen, MD

Doctor of Medicine: University of Miami Miller School of Medicine

Residency: UCLA Medical Center

Fellowship: UCLA Medical Center

Joseph Cleveland, MD

Doctor of Medicine: Texas A&M Health Science Center College of Medicine

Fellowship: Stanford University Medical Center/Stanford Cancer Center

Arjan Gower, MD

Doctor of Medicine: Chicago Medical School, North Chicago, IL

Residency: Cedars Sinai Medical Center, Los Angeles, CA

Jingran Ji, MD

Doctor of Medicine: Northwestern Feinberg School of Medicine

Residency: UC Davis Internal Medicine Residency

Fellowship: City of Hope Hematology/Oncology

Jasmine Mitchell, MD

Doctor of Medicine: Sidney Kimmel Medical College, Philadelphia, PA

Residency: Loma Linda University Medical Center, Loma Linda, CA

Fellowship: University of California, Los Angeles Medical Center

Diane Prager, MD

Doctor of Medicine: University of Witwatersrand, South Africa

Residency: Cedars-Sinai Medical Center/UCLA School of Medicine

Maria Velez Velez, MD

Doctor of Medicine: Universidad CES

Residency: University of Pittsburgh Medical Center

HOSPITALIST

Osei Boadu, MD

Doctor of Medicine: University of Rochester School of Medicine and Dentistry

Tianyu "Sissi" Chen, MD

Residency: Kaiser Permanente, San Francisco

Maryam Hajiabbasi, MD

Doctor of Medicine: Tabriz University of Medical Sciences, Tabriz, Iran

Residency: Icahn School of Medicine at Mount Sinai/NYC H+H Elmhurst, Queens, NY

Evan Jackson, MD

Doctor of Medicine: Meharry Medical College

Residency: Keck School of Medicine of USC

Kevin Keller, MD

Doctor of Medicine: Albany Medical College, NY

Residency: Boston Medical Center, MA

Thomas Kingsley, MD, MPH, MS

Doctor of Medicine: University of Massachusetts Medical School

Residency: New York University School of Medicine

Alex Kokaly, MD, MHSA

Doctor of Medicine: University of Michigan Medical School & University of Michigan School of Public Health

Marek Kowalski, MD

Robert Kropp, MD

Doctor of Medicine: University of Tennessee Health Science Center, Memphis, TN

Residency: Southern Illinois University, Springfield, IL

Albert Liu, MD

Doctor of Medicine: New York University, NYU Grossman School of Medicine

Isabel Lopez, MD

Doctor of Medicine: Texas Tech University Health Sciences Center

Residency: Emory University School of Medicine

Ana Mohammad-Zadeh, MD

Doctor of Medicine: University of Oklahoma College of Medicine

Residency: Cedars Sinai Medical Center

Ashley Pournamdari, MD

Doctor of Medicine: University of California, San Francisco

Eden Sharabi, MD, MS

Doctor of Medicine: Northwestern University, Feinberg School of Medicine

Kyle Strouse, MD

Doctor of Medicine: Wayne State University School of Medicine 

Residency: HCA West Florida Oak Hill Hospital

Nisha Sunku, MD

Doctor of Medicine: University of South Florida, Morsani College of Medicine

Kruti Vora, MD

Doctor of Medicine: Harvard Medical School

Residency: Massachusetts General Hospital

Helen Xu, MD

Doctor of Medicine: Sidney Kimmel Medical College at Thomas Jefferson University

Erin Yim, MD

Doctor of Medicine: Loma Linda University School of Medicine

Residency: University of Southern California, Los Angeles

INFECTIOUS DISEASES

Alexandria Borys, NP

Master of Science in Nursing: University of California, Los Angeles

Katherine Li, MD

Doctor of Medicine: Weill Cornell Medicine

Anita Sircar, MD

Residency: Santa Barbara Cottage Hospital

Fellowship: UCLA/Cedars-Sinai Multi-Campus

Farid Arman, MD

Doctor of Medicine: Shahid Beheshti University of Medical Sciences

Residency: Icahn School of Medicine at Mount Sinai

PALLIATIVE CARE

Jessica Lucier, MD

David Oh, MD

Doctor of Medicine: Tufts University School of Medicine

Residency: Kaiser Permanente, Oakland Medical Center 

Fellowship: University of California, Los Angeles 

PULMONARY & CRITICAL CARE

Ruchika Sangani, MD

Doctor of Medicine: Upstate Medical University, Syracuse, NY

Residency: Boston University Medical Center

Fellowship: Boston University Medical Center

RHEUMATOLOGY

Neha Singh, DO, MS

Doctor of Osteopathic Medicine: Arizona College of Osteopathic Medicine, Midwestern University

Residency: University of California, Riverside

Fellowship: University of California, San Diego

Travis Patrick Welsh, MD

Doctor of Medicine: Medical College of Georgia

Residency: UT Southwestern Medical Center

SLEEP MEDECINE

Thien Nguyen, DO

Doctor of Osteopathic Medicine: Lake Erie College of Osteopathic Medicine

Residency: Waco Family Medicine Institute

Neal Walia, MD

Residency: University of California, Davis Health

Tags: Announcements

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