clara sailer md phd msc

BWH IM Residency Program

Science in residency, science in residency pathway.

The Brigham has a long tradition of supporting the development of physician-scientists, and through the Science in Residency (SiR) pathway, we continue to keep that tradition alive.

Our goal is to provide an interface between the exemplary clinical care within the BWH Internal Medicine residency program and the incredibly rich basic and translational research environment that exists here at Brigham and Women’s Hospital.

Pathway Features

An integral component of the SiR pathway is a dedicated mentoring infrastructure headed by pathway director Dr. Rebecca Baron and that draws from the scientific community at large between Brigham and Women’s Hospital, Harvard Medical School, MIT, and other affiliated institutions.

Programming

The SiR pathway facilitates interest and engagement in science, within Brigham and Women’s Hospital and in the greater Boston community at large. The tentpole feature is the SiR research course (“bootcamp”), which runs during a 2-week July elective block shared by all juniors and seniors in the SiR pathway. The bootcamp features structured talks and seminars from leading physician-scientists across all disciplines, as well as field trips to meet with leadership at local institutions including Vertex Pharmaceutical, the Broad Institute and more. Other events include evening discussions, specialized noon conferences, and semi-annual dinners, culminating in the Resident Research Day symposium at the end of the year.

Research support

Through generous alumni and residency program support, SiR members engage in their own research activities during residency and also have the opportunity to participate in group research projects harnessing a robust translational research program that includes access to analysis of existing patient biospecimens, collection of novel patient cohort biospecimens, and educational opportunities in genetics, genomics, and big data analysis.

Frequently Asked Questions

​There is no advanced application process that is needed for SiR, and there is no separate application apart from the categorical residency application for physician scientists. ​All matriculated interns are invited to apply for participation in the various different pathways in the Fall of their intern year. However, there are plenty of exciting opportunities to be involved in SiR events from week one of your Brigham residency, so just keep an eye on your email! For prospective students, if you have questions before, during, or after your BWH residency interview, please contact us.

The SiR group provides mentorship, community, and many fantastic events for physician-scientists. Our goal is to help residents who are passionate about science engage their interests during residency, and additionally help them further develop their career paths.

The SiR Bootcamp is targeted primarily to residents with a strong laboratory science background. It is designed to be an educational and immersive experience in basic science that comes right after your rigorous clinical intern year. It offers an exposure to a wide array of rigorous laboratory-based scientists from around the Boston community, and also provides structured career development advice for those who are thinking about clinical fellowship, post-doctoral research fellowship, and beyond. The SIR pathway hopes to foster a residency-wide community of scientists to help brainstorm ideas, practice presentations and provide career counseling to physician-scientists.

No problem! No requirement to focus on a subspecialty is required! Rebecca Baron is our head faculty member, and will work with you to determine the right mentorship. If you are deciding between more than one subspecialty, then it may be beneficial to have a mentor in each. If you decide not to subspecialize, we will find you a great mentor who fits your research interests.

Of course! The goal of this pathway is to facilitate mentorship and guidance for residents interested in careers as physician-scientists who seek primarily laboratory-based careers. If you short track, you will still benefit from the two-week research bootcamp course and all the conference series and networking opportunities during your time in residency.

The 2-week SiR bootcamp in July will substitute for one elective block in your junior and senior years. You will still be granted a second elective block in junior year that can be utilized as you see fit (clinical elective, research, etc). For senior year, you will still be given the same amount of additional elective time as all residents.

No formal research background is required. However, SiR is designed for residents who intend to pursue primarily laboratory-based research careers. Although the majority of people in the pathway have engaged in prior laboratory-based research, this is not a requirement. If you see yourself pursuing this mode of research or you seek to gain more exposure, we welcome your participation!

The SiR pathway is specifically geared towards the advice and mentorship of residents who intend to pursue primarily laboratory-based careers, and the career development and lecture series will be focused on the basic/translational sciences. While we welcome all residents, this would be less useful for those interested in research careers in the clinical, epidemiological, or educational realms. We are also closely aligned with the Clinical Investigator Pathway within the residency, which provides more of an emphasis on clinical-based research careers, and there are other pathways that allow residents to focus on other interests.

The SiR program hosts various events throughout the year, from formal lectures and mentoring meetings, to informal dinners. A brief overview of these events is provided below.

Evening Discussions

This is a monthly to bi-monthly lecture series during which an invited physician-scientist gives a one-hour talk on a weekday evening. Typically, during the first half-hour he or she talks about their background, training, and career development, while the second half focuses on their research. These discussions vary throughout the year and sometimes include more specific topics, such as mentoring, funding, and writing grants, or SiR members giving chalk talks to each other about their research interests, or other topics of their choosing. As always, food is provided!

End of Year Symposium

In collaboration with the Internal Medicine Resident Research Day, SiR members present their work to the Department of Medicine in a yearly symposium each May.

Semi-Annual Dinners

Every year we have two residency sponsored dinners. They serve as a time to build community and foster discussion among SiR members.

Pathway leadership

Rebecca baron, md, associate program director for research and scholarship director, science in residency pathway.

Maxwell Coll, MD

Chief resident liaison.

Current Residents

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Endocrine Fellowship Program

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Current Endocrinology Fellows

First year fellows.

Brandon Bertot, MD

Medical School: Baylor College of Medicine, TX

Residency: Brigham and Women's Hospital, Boston

Nathalie Morais, MD, PhD

Medical School: Universidade Federal do Rio de Janeiro Faculdade de Medicine, Rio de Janeiro, Brazil

Residency: Clementino Fraga Filho University Hospital, Rio de Janeiro, Brazil

Clara Sailer, MD, PhD

Medical School: Universitët Basel Medizinische Fakultät, Switzerland

Residency: Brigham and Women's Hospital, Boston, MA

Second Year Fellows

Thiago Gagliano, MD, PhD

Medical School: Universidade Federal do Rio de Janeiro (UFRJ) Faculdade de Medicina, Brazil

Residency: Northwestern Medicine McHenry Hospital, McHenry, IL

Maged Muhammed, MD

Medical School: University of Aleppo Faculty of Medicine, Syria

Residency: St. Elizabeth's Medical Center. Boston, MA

Ana Maria Stanton, MD

Medical School: Universidad Santiago de Cali Facultad de Salud, Campus Pampalinda, Colombia

Residency: Universidad de Caldas, Facultad de Ciencias para la salud Manizales, Colombia

Fellowship: Pontificia Universidad Javeriana, Bogota, Facultad de Medicina Bogota, Colombia

Third Year Fellows

Yumi Kang, MD

Medical School:  Chonbuk National University College of Medicine, Korea

Residency:  Yale New Haven Health, Bridgeport Hospital, CT

Andrew Newman, MD

Medical School: Florida International University  Herbert Wertheim College of Medicine , Miami, FL

Residency:  Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ

Emilia Thurber, MD

Medical School: Johns Hopkins University School of Medicine, Baltimore, MD

Residency:  Brigham and Women's Hospital, Boston, MA

Fourth Year Fellows

Francesca Galbiati, MD

Medical School:  Università degli Studi di Milano Bicocca Facoltà di Medicina e Chirurgia, Italy

Residency:  University Of Pittsburgh Medical Center, PA

Yan Emily Yuan, MD

Medical School:  University of Massachusetts Medical School, Worcester, MA

Residency: Brigham and Women's Hospital

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• DOI: 10.1210/jendso/bvac150.536
• Corpus ID: 253393814

RF32 | PSUN59 Glucagon-Like Peptide-1 Analogues: A New Way to Quit Smoking? SKIP – a Randomised Controlled Study

• Cihan Atila , T. Burkard , +16 authors S. Lengsfeld
• Published in Journal of the Endocrine… 7 May 2022

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Relationship Between Oxytocin Levels and Brain Volume in Anorexia Nervosa Compared to Healthy Controls

Clara odilia sailer.

1 Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Lauren Breithaupt

2 Eating Disorders Clinical and Research Program, Harvard Medical School, Boston, MA, USA

Amanda E Lyall

3 Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Brynn Vessey

4 Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA, USA

Franziska Plessow

Danielle l kahn.

5 Neuroendocrine Unit, Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA

Meghan Slattery

6 Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA

Laura Holsen

7 Division of Women’s Health, Department of Medicine, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Kamryn T Eddy

8 Eating Disorders Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Madhusmita Misra

9 Neuroendocrine Unit, Massachusetts General Hospital, Division of Pediatric Endocrinology, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA

Elizabeth Austen Lawson

10 Massachusetts General Hospital, Boston, MA, USA

Background: A disruption in food motivation pathways has been described in females with anorexia nervosa (AN), a psychiatric disorder characterized by food restriction despite low weight. We have shown that in AN and healthy controls (HC), levels of oxytocin (OXT), a hormone involved in lactation, social behavior and weight regulation, decrease after a meal. In HC, we identified a relationship between postprandial change in OXT and subjective appetite, yet this association was absent in females with AN, suggesting a disconnect between OXT and appetite regulation in AN. Prior studies have shown that gray matter volume of the amygdala and hippocampus, areas rich in OXT receptors, correlate with OXT levels in HC. Furthermore, these regions play a central role in food reward and decreased volume has been reported in AN. We hypothesized that the relationship between postprandial change in OXT and amygdala and hippocampal gray matter volume would differ between AN and HC.

Methods: We performed a cross-sectional study of 51 females (23 restrictive AN; 28 HC). We drew blood for OXT levels fasting and 60 min after a standard meal and performed T1-weighted MRI scans of the brain in the fasted state. MRI data was quality controlled and processed with FreeSurfer. Average gray matter brain volumes were extracted from the bilateral amygdala and hippocampus for each subject. Linear regression models were used to determine differences between AN and HC of postprandial percent change in OXT on amygdala and hippocampus gray matter volume.

Results: Median [IQR] age was higher in females with AN (20.6 years [19.3, 21.5]) than HC (18.8 years [IQR 17.6, 20.3], p =0.02), and percentage of ideal body weight was lower in AN (75.5%) than HC (97.4%, p <0.01). Right hippocampus volume, adjusted for age and total intracranial volume, was significantly lower in AN (estimated difference -188 dm 3 [95%-CI -360, -17], p =0.04). Percent change in OXT was not different ( p =0.5) but there was a trend for a positive interaction effect ( p =0.08) for AN and percent change in OXT on right hippocampus volume. Posthoc exploratory analysis indicated a positive correlation in AN (R 2 =0.41, p =0.02) and no correlation in HC (R 2 =0.17, p =0.4) between percent change in OXT and right hippocampus volume. There was no significant between group difference in volume nor postprandial change in OXT for the bilateral amygdala or left hippocampus between groups.

Discussion: Our results indicate smaller right hippocampus volume and a trend towards a positive association with postprandial change in OXT in AN compared to HC. Future studies will be important to better define the relationships between OXT secretion and food motivation brain regions and the impact on eating behavior in AN.

Career Talks

Pphs career talks.

Description

Orientation for your (future) career can be overwhelming. What jobs do exist? What are my chances? Where do you start?

PPHS invites alumni in- and outside academia to give an insight into their own career paths.

• How did they end up in that position after their PhD?
• What were the reasons to decide to follow that specific career path?

They will talk about their work responsibilities, explain their everyday tasks, and depict the advantages and disadvantages of their work. Furthermore, they will explain how they transitioned from their PhD into the job and how they planned their career.

Each semester, 3 speakers are invited to talk about their careers. We invite PPHS alumni and PPHS supervisors. The presenters will give you an insight into their career path and answer your questions.

In the online sessions we provide a balance between input by the speakers and the possibility to ask questions in smaller groups.

Participants

The event is open to all PPHS members as well as other PhD students in the Health Sciences of the University of Basel, and SSPH+ IGC members.

Speakers 2024

Do you have any suggestions for speakers? Please let us know at [email protected]!

Registration

10 October, 4-6 pm

Event summaries

Speakers 2023 november.

Julia Wolleb, Ph.D. – Post doc at the Center for medical Image Analysis & Navigation (CIAN)

Christoph Werner, Ph.D. – Country Approval Specialist, Clinical Research Group, Clinical Development and Service Division, PPD part of Thermo Fisher Scientific

Paola Salari, Ph.D. – Scientific Project Officer at the Joint Research Center (European Commission)

Speaker 2023 June

• Susan Edvards, Principal Data Scientist (Epidemiologist) at Roche: Work as an epidemiologist in the pharmaceutical industry 
• Joshua Galjour, Senior Fund Portfolio Manager – Southern and Eastern Africa Team, The Global Fund: Exploring alternatives with a multi-purposed PhD

Speakers 2022 November

Speakers November 2022

Yu-Shiuan is a psychologist originally from Taiwan. After working 3 years as a research assistant in Taipei, she fell in love with research and therefore pursued her master’s degree at King’s College London and a PhD in Basel. In her 10-year journey in academia, Yu-Shiuan has conducted research on ADHD, psychosis, and caffeine. During her PhD at Centre for Chronobiology in Basel, the topic of caffeine effects on neurocognitive functions inspired her interest in the beauty of adenosine system and its neuromodulations. In order to be able to study adenosine, Yu-Shiuan obtained the SNF Doc.Mobility fellowship to learn positron emission tomography (PET) imaging method at Forschungszentrum Jülich. Currently, Yu-Shiuan is leading a pharmacological behavioral study on caffeine and dopamine-modulated neurobehaviors at UPK, and at the same time doing a Postdoc.Mobility fellowship at Harvard conducting a pharmacological PET/fMRI study on the adenosine-modulated neurotransmission.

Paco is a purpose-driven healthcare professional highly committed to evaluating and improving healthcare globally. In his current role at Roche Diabetes Care (RDC), he leads evidence generation within the Global Market Access department. His activities are focusing on demonstrating the value of RDC solutions to patients, healthcare professionals and payers with the ultimate goal to increase access worldwide. As a background, Paco is a chronic disease epidemiologist holding a PhD from the Swiss Tropical and Public Health Institute. At Roche, Paco is able to fully express his passion and curiosity for leadership in healthcare by being rooted in an agile culture of diversity and integrity that paves the way for impactful innovations. Paco is Swiss and Italian and lives in Basel with his partner. He spends lot of his spare time on the tennis court.

Karin is a nurse by training with 20 years of clinical experience in paediatric oncology. Late in her life she started her university studies in nursing science and defended her dissertation in 2016 in the field of paediatric palliative and end-of-life care (PELICAN study). Shortly after, she transitioned into the postdoc phase and developed and designed the SPhAERA study as continuation of the PELICAN study. The SPhAERA study (2019-2023) is a collaboration with the University Children’s Hospital Zürich (PD Dr. med. Eva Bergsträsser) and received funding of approximately CHF 500’000.- from various sponsors. Karin supervises two doctoral students and is “Forschungsgruppenleiterin” at the Department of Public Health, Faculty of Medicine, University of Basel.

Speakers 2022 June

Miriam Njoki Karinja, PhD – Clinical Epidemiologist, World Food Program Miriam Njoki Karinja obtained her PhD in 2019 in Epidemiology at Swiss TPH in Basel. She is an epidemiologist with an interest in infectious diseases, nutritional surveillance, health systems strengthening, and the use of technology to advance the delivery of health services. Njoki has extensive experience working with public-private partnerships to design, implement and evaluate health interventions in low- and middle-income countries. In her current position she works as data, analytics, and research consultant in the research, evidence, and policy team at the World Food Programme (WFP).

Aurelio Di Pasquale , PhD – Software Project Coordinator, Household Economics & Health Systems Research Unit at Swiss TPH Aurelio Di Pasquale received his PhD in Epidemiology in 2018 at the University of Basel on the topic of improving quality, timeliness and efficacy of data collection and management. Aurelio is now applying his knowledge of data management in research support, Research IT, and teaching. In addition, Aurelio is a member of the WHO Verbal Autopsy Reference Group, and member of the Technical Advisory Board of the ODK Ecosystem.

Speakers 2021 November

Belinda von Niederhäusern, PhD – Senior Patient Partnership Manager at Roche Pharma

Apolline Saucy, PhD –  postdoctoral researcher at the Barcelona  Institute for Global Health

Prof. Martin Röösli, PhD – Head of Unit “Environmental Exposures and Health”, Swiss TPH

Speakers 2021 June

PPHS is a collaboration of:

Dr. Clara Sailer MD, PHD

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